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Casp1 Gene Detail
Summary
  • Symbol
    Casp1
  • Name
    caspase 1
  • Synonyms
    Caspase-1, ICE, Il1bc, interleukin 1 beta-converting enzyme
  • Feature Type
    protein coding gene
  • IDs
    MGI:96544
    NCBI Gene: 12362
  • Gene Overview
    MyGene.info: CASP1
  • Alliance
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:5298517-5307265 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 2.46 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    117 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96544
protein coding gene Chr9:5298517-5307281 (.)
129S1/SvImJ MGP_129S1SvImJ_G0034312
protein coding gene Chr9:2060228-2068900 (+)
A/J MGP_AJ_G0034289
protein coding gene Chr9:2167767-2176535 (+)
AKR/J MGP_AKRJ_G0034219
protein coding gene Chr9:2028114-2036875 (+)
BALB/cJ MGP_BALBcJ_G0034283
protein coding gene Chr9:1962105-1970873 (+)
C3H/HeJ MGP_C3HHeJ_G0033995
protein coding gene Chr9:2227510-2236278 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034805
protein coding gene Chr9:2205792-2214562 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031743
protein coding gene Chr9:1708210-1716999 (+)
CAST/EiJ MGP_CASTEiJ_G0033322
protein coding gene Chr9:2262261-2271843 (+)
CBA/J MGP_CBAJ_G0033967
protein coding gene Chr9:2179236-2188033 (+)
DBA/2J MGP_DBA2J_G0034124
protein coding gene Chr9:2146891-2155631 (+)
FVB/NJ MGP_FVBNJ_G0034069
protein coding gene Chr9:1957573-1966335 (+)
LP/J MGP_LPJ_G0034211
protein coding gene Chr9:2079213-2087983 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0034113
protein coding gene Chr9:2664578-2687859 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034824
protein coding gene Chr9:2030840-2039610 (+)
PWK/PhJ MGP_PWKPhJ_G0033026
protein coding gene Chr9:2261988-2271070 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032863
protein coding gene Chr9:2323760-2332565 (+)
WSB/EiJ MGP_WSBEiJ_G0033438
protein coding gene Chr9:2061865-2070649 (+)



Homology
more
  • Human Ortholog
    CASP1, caspase 1
  • Vertebrate Orthologs
    13
  • Human Ortholog
    CASP1, caspase 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    ICE, IL1BC, P45
  • Links
    NCBI Gene ID: 834
    neXtProt AC: NX_P29466
    UniProt: P29466

  • Chr Location
    11q22.3; chr11:105025508-105035591 (-)  GRCh38.p7

Human Diseases
less
  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    75 phenotypes from multigenic genotypes
    423 phenotype references
Homozygous targeted mutants fail to produce mature IL1A and IL1B and are resistant to LPS-induced endotoxin shock and to FAS antibody-induced apoptosis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000025888 Ensembl Gene Model | MGI Sequence Detail 8749 C57BL/6J ±  kb
transcript ENSMUST00000027015 Ensembl | MGI Sequence Detail 1497 Not Applicable  
polypeptide ENSMUSP00000027015 Ensembl | MGI Sequence Detail 402 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 60
    Genomic 2
    cDNA 54
    Primer pair 3
    Other 1

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-11368
References
more
  • Summaries
    All 593
    Developmental Gene Expression 12
    Diseases 2
    Gene Ontology 28
    Phenotypes 423
  • Earliest
    J:229737 Idell S, et al., Local abnormalities in coagulation and fibrinolytic pathways predispose to alveolar fibrin deposition in the adult respiratory distress syndrome. J Clin Invest. 1989 Aug;84(2):695-705
  • Latest
    J:266038 Tumurkhuu G, et al., Chlamydia pneumoniae Hijacks a Host Autoregulatory IL-1beta Loop to Drive Foam Cell Formation and Accelerate Atherosclerosis. Cell Metab. 2018 Sep 4;28(3):432-448.e4

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/04/2018
MGI 6.13
The Jackson Laboratory