Casp1 MGI Mouse Gene Detail - MGI:96544

Casp1 Gene Detail

Symbol

Casp1
Name

caspase 1
Synonyms

Caspase-1, ICE, Il1bc, interleukin 1 beta-converting enzyme

Feature Type

protein coding gene
IDs

MGI:96544
NCBI Gene: 12362
Gene Overview

MyGene.info: CASP1
Alliance

gene page

Sequence Map

Chr9:5298517-5307265 bp, + strand
From Ensembl annotation of GRCm38

Mouse Genome Browser
Download
Sequence

8749 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 9, 2.46 cM
Mapping Data

2 experiments

Human Ortholog

CASP1, caspase 1

Vertebrate Orthologs

13

Human Ortholog

CASP1, caspase 1
Orthology source: HomoloGene, HGNC
Synonyms

ICE, IL1BC, P45
Links

HGNC:1499

NCBI Gene ID: 834

neXtProt AC: NX_P29466

UniProt: P29466
Chr Location

11q22.3; chr11:105025508-105035591 (-) GRCh38.p7

HomoloGene

Vertebrate Homology Class 133272
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;4 zebrafish;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: CASP1
Protein SuperFamily

caspase, interleukin-1 beta convertase type
Gene Tree

Casp1

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Mutations/Alleles

2 with disease annotations

References

2 with disease annotations

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Phenotype Summary

75 phenotypes from multigenic genotypes
417 phenotype references

All Mutations and Alleles

12
Targeted

11
Transgenic

1
Genomic Mutations

1 involving Casp1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

26 strains or lines available

Homozygous targeted mutants fail to produce mature IL1A and IL1B and are resistant to LPS-induced endotoxin shock and to FAS antibody-induced apoptosis.

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All GO Annotations

80
GO References

28

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

18
Tissues

11
cDNA Data

54
Literature Summary

12

Images

Tissue x Stage Matrix

Other Mouse Links

GEO

Expression Atlas
Other Vertebrate Links

Xenbase casp1

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Casp1 interacts with 25 markers (Mir26a-2, Mir32, Mir33, ...) View All

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All Sequences

13
RefSeq

2
UniProt

1
CCDS

CCDS22798.1
UniGene

1051

Ensembl

ENSMUSG00000025888 (Evidence)
NCBI Gene

12362

			Length	Strain/Species	Flank
genomic	ENSMUSG00000025888	Ensembl Gene Model \| MGI Sequence Detail	8749	C57BL/6J	± kb
transcript	ENSMUST00000027015	Ensembl \| MGI Sequence Detail	1497	Not Applicable
polypeptide	ENSMUSP00000027015	Ensembl \| MGI Sequence Detail	402	Not Applicable

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SNPs within 2kb

117 from dbSNP Build 142

RFLP

1

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UniProt

1 Sequence
Protein Ontology

PR:000002309 caspase-1

(term hierarchy)
EC

3.4.22.36
InterPro Domains

IPR001315 CARD domain

IPR029030 Caspase-like domain superfamily

IPR011029 Death-like domain superfamily

IPR015917 Peptidase C14A, caspase catalytic domain

IPR002138 Peptidase C14, caspase non-catalytic subunit p10

IPR001309 Peptidase C14, p20 domain

IPR033139 Peptidase family C14A, cysteine active site

IPR016129 Peptidase family C14A, His active site

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All nucleic 60

Genomic 2

cDNA 54

Primer pair 3

Other 1

Microarray probesets 3

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MGD-MRK-11368

Summaries

All 587

Developmental Gene Expression 12

Diseases 2

Gene Ontology 28

Phenotypes 417
Earliest

J:229737 Idell S, et al., Local abnormalities in coagulation and fibrinolytic pathways predispose to alveolar fibrin deposition in the adult respiratory distress syndrome. J Clin Invest. 1989 Aug;84(2):695-705
Latest

J:265326 Pinho-Ribeiro FA, et al., Blocking Neuronal Signaling to Immune Cells Treats Streptococcal Invasive Infection. Cell. 2018 May 17;173(5):1083-1097.e22

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 10/16/2018 MGI 6.12