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Casp1
Gene Detail
 Symbol
Name
ID
Casp1
caspase 1
MGI:96544
Synonyms Caspase-1, ICE, Il1bc, interleukin 1 beta-converting enzyme
Feature Type protein coding gene
Genetic Map
Chromosome 9
2.46 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr9:5298517-5307265 bp, + strand
From Ensembl annotation of GRCm38

  8749 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:133272  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 4 zebrafish

Protein SuperFamily: caspase, interleukin-1 beta convertase type
Gene Tree: Casp1

Human
homologs
Human Homolog CASP1, caspase 1, apoptosis-related cysteine peptidase
NCBI Gene ID 834
neXtProt AC  NX_P29466
Human Synonyms  ICE, IL1BC, P45
Human Chr (Location)  11q23; chr11:105025508-105035190 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous targeted mutants fail to produce mature IL1A and IL1B and are resistant to LPS-induced endotoxin shock and to FAS antibody-induced apoptosis.
 
Alleles Annotated to Human Diseases(1)   
Interactions
Casp1 interacts with 25 markers (Mir26a-2, Mir32, Mir33, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (58 annotations)
Process apoptotic process, cellular response to organic substance, ...
Component AIM2 inflammasome complex, cytoplasm, ...
Function cysteine-type endopeptidase activity, cysteine-type peptidase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (9 records)
Data Summary: Results (12)    Tissues (10)    Images (1)
Theiler Stages: 4, 18, 20, 21, 23, 25, 26, 27
Assay TypeResults
RT-PCR 7
RNase protection 5
cDNA source data(53)
External Resources: GEO   Expression Atlas
Molecular
reagents
All nucleic(59) Genomic(2) cDNA(53) Primer pair(3) Other(1)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000025888 (Evidence)
Entrez Gene12362 (Evidence)
UniGene1051
DFCITC1582316
DoTSDT.110628215, DT.87072414, DT.91378771
NIA Mouse Gene IndexU010012
EC3.4.22.36
Consensus CDS ProjectCCDS22798.1
International Mouse Knockout Project StatusCasp1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000025888 Ensembl Gene Model | MGI Sequence Detail 8749 C57BL/6J ±  kb
transcript ENSMUST00000027015 Ensembl | MGI Sequence Detail 1497 Not Applicable 
polypeptide ENSMUSP00000027015 Ensembl | MGI Sequence Detail 402 Not Applicable 

For the selected sequences
All sequences(18) RefSeq(2) UniProt(1)
Polymorphisms RFLP(1) : SNPs within 2kb(131 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017350 Caspase, interleukin-1 beta convertase
InterPro IPR001315 Caspase Recruitment
InterPro IPR011029 Death-like domain
InterPro IPR011600 Peptidase C14, caspase catalytic
InterPro IPR002138 Peptidase C14, caspase non-catalytic subunit p10
InterPro IPR015917 Peptidase C14, caspase precursor p45, core
InterPro IPR001309 Peptidase C14, ICE, catalytic subunit p20
InterPro IPR016129 Peptidase C14, ICE, catalytic subunit p20, active site
Protein Ontology PR:000002309 caspase-1
References (Earliest) J:11260 Eisenberg SP, et al., Interleukin 1 receptor antagonist is a member of the interleukin 1 gene family: evolution of a cytokine control mechanism. Proc Natl Acad Sci U S A. 1991 Jun 15;88(12):5232-6
(Latest) J:212020 Wlodarska M, et al., NLRP6 inflammasome orchestrates the colonic host-microbial interface by regulating goblet cell mucus secretion. Cell. 2014 Feb 27;156(5):1045-59
All references(388)
Other
accession IDs
MGD-MRK-11368

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory