Casp1 MGI Mouse Gene Detail - MGI:96544

Casp1 Gene Detail

Symbol

Casp1
Name

caspase 1
Synonyms

Caspase-1, ICE, Il1bc, interleukin 1 beta-converting enzyme

Feature Type

protein coding gene
IDs

MGI:96544
NCBI Gene: 12362
Gene Overview

MyGene.info: CASP1

Sequence Map

Chr9:5298517-5307265 bp, + strand
From Ensembl annotation of GRCm38

Mouse Genome Browser
Download
Sequence

8749 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 9, 2.46 cM
Mapping Data

1 experiment

Human Ortholog

CASP1, caspase 1

Vertebrate Orthologs

13

Human Ortholog

CASP1, caspase 1
Orthology source: HomoloGene, HGNC
Synonyms

ICE, IL1BC, P45
Links

HGNC:1499

NCBI Gene ID: 834

neXtProt AC: NX_P29466
Chr Location

11q23; chr11:105025508-105036662 (-) GRCh38.p2

HomoloGene

Vertebrate Homology Class 133272
1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;4 zebrafish;1 frog, western clawed
HCOP

human homology predictions: CASP1
Protein SuperFamily

caspase, interleukin-1 beta convertase type
Gene Tree

Casp1

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Mutations/Alleles

2 with disease annotations

References

4 with disease annotations

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Phenotype Summary

74 phenotypes from multigenic genotypes
336 phenotype references

All Mutations and Alleles

9
Targeted

8
Transgenic

1
Genomic Mutations

1 involving Casp1
Incidental Mutations

Mutagenetix , APF

Homozygous targeted mutants fail to produce mature IL1A and IL1B and are resistant to LPS-induced endotoxin shock and to FAS antibody-induced apoptosis.

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All GO Annotations

55
GO References

22

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

12
Tissues

10
cDNA Data

53
Literature Summary

9

Images

Tissue x Stage Matrix

Other Mouse Links

GEO
Other Vertebrate Links

Xenbase casp1

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Casp1 interacts with 25 markers (Mir26a-2, Mir32, Mir33, ...) View All

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All Sequences

13
RefSeq

2
UniProt

1
CCDS

CCDS22798.1
UniGene

1051

Ensembl

ENSMUSG00000025888 (Evidence)
NCBI Gene

12362

			Length	Strain/Species	Flank
genomic	ENSMUSG00000025888	Ensembl Gene Model \| MGI Sequence Detail	8749	C57BL/6J	± kb
transcript	ENSMUST00000027015	Ensembl \| MGI Sequence Detail	1497	Not Applicable
polypeptide	ENSMUSP00000027015	Ensembl \| MGI Sequence Detail	402	Not Applicable

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SNPs within 2kb

117 from dbSNP Build 142

RFLP

1

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UniProt

1 Sequence
Protein Ontology

PR:000002309 caspase-1
EC

3.4.22.36
InterPro Domains

IPR001315 CARD domain

IPR029030 Caspase-like domain

IPR011029 Death-like domain

IPR015917 Peptidase C14A, caspase catalytic domain

IPR017350 Peptidase C14A, interleukin-1 beta convertase type

IPR002138 Peptidase C14, caspase non-catalytic subunit p10

IPR001309 Peptidase C14, p20 domain

IPR033139 Peptidase family C14A, cysteine active site

IPR016129 Peptidase family C14A, His active site

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All nucleic 59

Genomic 2

cDNA 53

Primer pair 3

Other 1

Microarray probesets 3

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MGD-MRK-11368

Summaries

All 450

Developmental Gene Expression 9

Diseases 4

Gene Ontology 22

Phenotypes 336
Earliest

J:229737 Idell S, et al., Local abnormalities in coagulation and fibrinolytic pathways predispose to alveolar fibrin deposition in the adult respiratory distress syndrome. J Clin Invest. 1989 Aug;84(2):695-705
Latest

J:234731 Zoccal KF, et al., Opposing roles of LTB4 and PGE2 in regulating the inflammasome-dependent scorpion venom-induced mortality. Nat Commun. 2016;7:10760

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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