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Casp1 Gene Detail
Summary
  • Symbol
    Casp1
  • Name
    caspase 1
  • Synonyms
    Caspase-1, ICE, Il1bc, interleukin 1 beta-converting enzyme
  • Feature Type
    protein coding gene
  • IDs
    MGI:96544
    NCBI Gene: 12362
  • Alliance
    gene page
  • Transcription Start Sites
    16 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:5298517-5307281 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 2.46 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    335 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96544
 protein coding gene Chr9:5298508-5307290 (+)
129S1/SvImJ MGP_129S1SvImJ_G0034312
 protein coding gene Chr9:2060228-2068900 (+)
A/J MGP_AJ_G0034289
 protein coding gene Chr9:2167767-2176535 (+)
AKR/J MGP_AKRJ_G0034219
 protein coding gene Chr9:2028114-2036875 (+)
BALB/cJ MGP_BALBcJ_G0034283
 protein coding gene Chr9:1962105-1970873 (+)
C3H/HeJ MGP_C3HHeJ_G0033995
 protein coding gene Chr9:2227510-2236278 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034805
 protein coding gene Chr9:2205792-2214562 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031743
 protein coding gene Chr9:1708210-1716999 (+)
CAST/EiJ MGP_CASTEiJ_G0033322
 protein coding gene Chr9:2262261-2271843 (+)
CBA/J MGP_CBAJ_G0033967
 protein coding gene Chr9:2179236-2188033 (+)
DBA/2J MGP_DBA2J_G0034124
 protein coding gene Chr9:2146891-2155631 (+)
FVB/NJ MGP_FVBNJ_G0034069
 protein coding gene Chr9:1957573-1966335 (+)
LP/J MGP_LPJ_G0034211
 protein coding gene Chr9:2079213-2087983 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0034113
 protein coding gene Chr9:2664578-2687859 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034824
 protein coding gene Chr9:2030840-2039610 (+)
PWK/PhJ MGP_PWKPhJ_G0033026
 protein coding gene Chr9:2261988-2271070 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032863
 protein coding gene Chr9:2323760-2332565 (+)
WSB/EiJ MGP_WSBEiJ_G0033438
 protein coding gene Chr9:2061865-2070649 (+)



Homology
more
  • Human Ortholog
    CASP1, caspase 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CASP1, caspase 1
  • Synonyms
    ICE, IL1BC, P45
  • Links
    NCBI Gene ID: 834
    UniProt: P29466

  • Chr Location
    11q22.3; chr11:105025397-105036686 (-)  GRCh38
Human Diseases
less
  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    5 phenotypes from 1 allele in 1 genetic background
    54 phenotypes from multigenic genotypes
    695 phenotype references
Homozygous targeted mutants fail to produce mature IL1A and IL1B and are resistant to LPS-induced endotoxin shock and to FAS antibody-induced apoptosis. Another KO allele, in both homozygous and heterozygous state, protects against diabetic nephropathy.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    147
  • GO References
    53
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    745
  • Tissues
    21
  • cDNA Data
    54
  • Literature Summary
    22
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 12362 NCBI Gene Model | MGI Sequence Detail 8765 C57BL/6J ±  kb
transcript NM_009807 RefSeq | MGI Sequence Detail 1533 FVB/N  
polypeptide P29452 UniProt | EBI | MGI Sequence Detail 402 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 61
    Genomic 2
    cDNA 54
    Primer pair 4
    Other 1

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-11368
References
more
  • Summaries
    All 927
    Developmental Gene Expression 22
    Diseases 1
    Gene Ontology 53
    Phenotypes 695
  • Earliest
    J:11260 Eisenberg SP, et al., Interleukin 1 receptor antagonist is a member of the interleukin 1 gene family: evolution of a cytokine control mechanism. Proc Natl Acad Sci U S A. 1991 Jun 15;88(12):5232-6
  • Latest
    J:368330 Rabhi BV, et al., The bone phenotype associated with cherubism is independent of Caspase-1-dependent inflammasome activation in the mouse. PLoS One. 2025;20(2):e0318826
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory