Casp1
Gene Detail

Symbol

Name
ID

Casp1
caspase 1
MGI:96544

Synonyms

Caspase-1, ICE, Il1bc, interleukin 1 beta-converting enzyme

Feature Type

protein coding gene

Genetic Map

Chromosome 9
2.46 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr9:5298517-5307265 bp, + strand From Ensembl annotation of GRCm38   8749 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate
homology

HomoloGene:133272  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 4 zebrafish

Protein SuperFamily: caspase, interleukin-1 beta convertase type
Gene Tree: Casp1

Human
homologs

Human Homolog		CASP1, caspase 1, apoptosis-related cysteine peptidase
NCBI Gene ID		834
neXtProt AC		NX_P29466
Human Synonyms		ICE, IL1BC, P45
Human Chr (Location)		11q23; chr11:105025508-105035190 (-)  GRCh38

Mutations,
alleles, and
phenotypes

All mutations/alleles(7) : Targeted(6) Transgenic(1)
Genomic Mutations involving Casp1 (1)
Incidental mutations (data from Mutagenetix , APF )
 

Homozygous targeted mutants fail to produce mature IL1A and IL1B and are resistant to LPS-induced endotoxin shock and to FAS antibody-induced apoptosis.

 
Human Diseases Modeled in Mice Using Casp1 (1)    Mutations Annotated to Human Diseases (2)   

Interactions

Casp1 interacts with 25 markers (Mir26a-2, Mir32, Mir33, ...)

View All

Gene Ontology
(GO)
classifications

All GO classifications: (61 annotations)

Process	apoptotic process, cellular response to organic substance, ...
Component	AIM2 inflammasome complex, cytoplasm, ...
Function	cysteine-type endopeptidase activity, cysteine-type peptidase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (9 records)

Data Summary: Results (12)    Tissues (10)    Images (1)    Tissue x Stage Matrix (view)

Assay Type	Results
RT-PCR	7
RNase protection	5

cDNA source data(53)
External Resources: GEO   Expression Atlas

Molecular
reagents

All nucleic(59) Genomic(2) cDNA(53) Primer pair(3) Other(1)
Microarray probesets(3)

Other database
links

Ensembl Gene Model	ENSMUSG00000025888 (Evidence)
Entrez Gene	12362 (Evidence)
UniGene	1051
DFCI	TC1582316
DoTS	DT.87072414, DT.110628215, DT.91378771
NIA Mouse Gene Index	U010012
EC	3.4.22.36
Consensus CDS Project	CCDS22798.1
International Mouse Knockout Project Status	Casp1

Sequences

Length	Strain/Species
genomic	ENSMUSG00000025888	Ensembl Gene Model | MGI Sequence Detail	8749	C57BL/6J
transcript	ENSMUST00000027015	Ensembl | MGI Sequence Detail	1497	Not Applicable
polypeptide	ENSMUSP00000027015	Ensembl | MGI Sequence Detail	402	Not Applicable

All sequences(18) RefSeq(2) UniProt(1)

Polymorphisms

RFLP(1) : SNPs within 2kb(131 from dbSNP Build 137)

Protein-related
information

Resource	ID	Description
InterPro	IPR017350	Caspase, interleukin-1 beta convertase
InterPro	IPR001315	Caspase Recruitment
InterPro	IPR011029	Death-like domain
InterPro	IPR011600	Peptidase C14, caspase catalytic
InterPro	IPR002138	Peptidase C14, caspase non-catalytic subunit p10
InterPro	IPR015917	Peptidase C14, caspase precursor p45, core
InterPro	IPR001309	Peptidase C14, ICE, catalytic subunit p20
InterPro	IPR016129	Peptidase C14, ICE, catalytic subunit p20, active site
Protein Ontology	PR:000002309	caspase-1

References

(Earliest) J:11260 Eisenberg SP, et al., Interleukin 1 receptor antagonist is a member of the interleukin 1 gene family: evolution of a cytokine control mechanism. Proc Natl Acad Sci U S A. 1991 Jun 15;88(12):5232-6
(Latest) J:213866 Arifa RD, et al., Inflammasome activation is reactive oxygen species dependent and mediates irinotecan-induced mucositis through IL-1beta and IL-18 in mice. Am J Pathol. 2014 Jul;184(7):2023-34
All references(392)

Other
accession IDs

MGD-MRK-11368