Casp1 Phenotype Annotations - Multigenic Genotypes

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Casp1
caspase 1
MGI:96544

54 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Casp1^tm1Flv/Casp1^tm1Flv Casp4^del/Casp4^del B6.129S2-Casp1^tm1Flv	abnormal gut flora balance	J:173245
	decreased interleukin-1 beta secretion	J:160545
	decreased renal glomerular filtration rate	J:97733
	increased susceptibility to induced colitis	J:173245
	kidney failure	J:97733
	renal tubular necrosis	J:97733
Casp1^tm1Flv/Casp1^tm1Flv Casp4^del/Casp4^del involves: 129S2/SvPas	decreased metastatic potential	J:59893
	decreased susceptibility to induced morbidity/mortality	J:59893
	decreased tumor growth/size	J:59893
Casp1^tm1Flv/Casp1^tm1Flv Casp4^del/Casp4^del involves: 129S2/SvPas * C57BL/6	abnormal cytokine secretion	J:24258
	decreased circulating interferon-gamma level	J:115310
	decreased interferon-gamma secretion	J:115310
	decreased interleukin-1 alpha secretion	J:24258
	decreased interleukin-1 beta secretion	J:24258
	decreased interleukin-6 secretion	J:24258
	decreased interleukin-18 secretion	J:115310
	decreased susceptibility to endotoxin shock	J:43088
	decreased susceptibility to experimental autoimmune encephalomyelitis	J:57101
	decreased thymocyte apoptosis	J:24258
	decreased tumor necrosis factor secretion	J:24258
	impaired neutrophil chemotaxis	J:124226
	increased susceptibility to bacterial infection	J:117251
	kidney failure	J:69421
	renal tubular necrosis	J:69421
Casp1^tm1Flv/Casp1^tm1Flv Casp4^del/Casp4^del involves: 129S2/SvPas * C57BL/6J	decreased incidence of tumors by chemical induction	J:191239
	normal integument phenotype	J:191239
Casp1^tm1Flv/Casp1^tm1Flv Casp4^del/Casp4^del Il1r1^tm1Imx/Il1r1^tm1Imx involves: 129S2/SvPas * 129S7/SvEvBrd * C57BL/6	decreased susceptibility to endotoxin shock	J:43088
Casp1^tm1Flv/Casp1^tm1Flv Casp4^del/Casp4^del Slc11a1^r/Slc11a1^r involves: 129S2/SvPas	increased susceptibility to bacterial infection	J:124378
	increased susceptibility to induced morbidity/mortality	J:124378
Casp1^tm1Flv/Casp1^tm1Flv Casp4^del/Casp4^del Slc11a1^s/Slc11a1^s B6.129S2-Casp1^tm1Flv	cecum inflammation	J:124378
	increased susceptibility to bacterial infection	J:124378
	increased susceptibility to induced morbidity/mortality	J:124378
Casp1^tm1Flv/Casp1^tm1Flv St18^{tm1c(KOMP)Wtsi}/St18^{tm1c(KOMP)Wtsi} involves: C57BL/6 * C57BL/6N * DBA/2	increased susceptibility to induced morbidity/mortality	J:298828
Casp1^tm1Sesh/Casp1⁺ Casp4^del/Casp4⁺ involves: 129S1/SvImJ * 129S2/SvPas * NOD	abnormal macrophage physiology	J:99748
Casp1^tm1Sesh/Casp1⁺ Casp4^del/Casp4⁺ involves: 129S2/SvPas * C57BL/6	decreased interleukin-1 beta secretion	J:22964
Casp1^tm1Sesh/Casp1^tm1Sesh Casp4^del/Casp4^del B6.129S2(NOD)-Casp1^tm1Sesh Casp4^del	decreased apoptosis	J:243487
	decreased circulating interleukin-1 alpha level	J:193522
	decreased circulating interleukin-1 beta level	J:193522
	decreased circulating interleukin-18 level	J:193522
	decreased interleukin-1 alpha secretion	J:193522
	decreased interleukin-1 beta secretion	J:193522
	decreased interleukin-18 secretion	J:193522
	decreased macrophage apoptosis	J:193522
	decreased susceptibility to endotoxin shock	J:193522
	decreased susceptibility to xenobiotic induced morbidity/mortality	J:193522
Casp1^tm1Sesh/Casp1^tm1Sesh Casp4^del/Casp4^del B10.Cg-Casp1^tm1Sesh Casp4^del H2^r H2-T18^b	decreased apoptosis	J:63488
	decreased inflammatory response	J:63488
	decreased susceptibility to bacterial infection	J:63488
	decreased susceptibility to bacterial infection induced morbidity/mortality	J:63488
Casp1^tm1Sesh/Casp1^tm1Sesh Casp4^del/Casp4^del C3.129S2-Casp1^tm1Sesh Casp4^del	abnormal macrophage physiology	J:136368
	decreased interleukin-1 beta secretion	J:136368
	increased susceptibility to bacterial infection	J:136368
	increased susceptibility to bacterial infection induced morbidity/mortality	J:136368
Casp1^tm1Sesh/Casp1^tm1Sesh Casp4^del/Casp4^del C3N.129S2-Casp1^tm1Sesh Casp4^del	abnormal response to infection	J:86761
Casp1^tm1Sesh/Casp1^tm1Sesh Casp4^del/Casp4^del involves: 129 * 129S2/SvPas * C57BL/6	decreased interleukin-1 beta secretion	J:50775
Casp1^tm1Sesh/Casp1^tm1Sesh Casp4^del/Casp4^del involves: 129S2/SvPas * C57BL/6	abnormal apoptosis	J:80568
	abnormal cell migration	J:68644
	abnormal inflammatory response	J:80568
	abnormal macrophage physiology	J:22964
	abnormal neutrophil physiology	J:80568
	normal cardiovascular system phenotype	J:107324
	normal cellular phenotype	J:22964, J:40691
	decreased circulating interleukin-1 alpha level	J:22964
	decreased circulating interleukin-1 beta level	J:22964
	decreased circulating interleukin-6 level	J:22964
	decreased circulating tumor necrosis factor level	J:22964
	decreased interleukin-1 alpha secretion	J:22964
	decreased interleukin-1 beta secretion	J:22964, J:88212
	decreased neuron apoptosis	J:88212
	decreased susceptibility to endotoxin shock	J:22964, J:40691
	decreased susceptibility to ischemic brain injury	J:69589, J:98866
	decreased T cell apoptosis	J:40691
	normal hematopoietic system phenotype	J:22964
	normal immune system phenotype	J:40691
	normal neoplasm	J:22964, J:40691
	normal reproductive system phenotype	J:22964, J:40691
Casp1^tm1Sesh/Casp1^tm1Sesh Casp4^del/Casp4^del NOD.129S2(B6)-Casp1^tm1Sesh Casp4^del/LtJ	decreased interleukin-1 alpha secretion	J:87250
	decreased interleukin-1 beta secretion	J:87250
	decreased interleukin-18 secretion	J:87250
	normal homeostasis/metabolism phenotype	J:87250
Casp1^tm1Sesh/Casp1^tm1Sesh Casp4^del/Casp4^del Slc11a1^r/Slc11a1^s involves: 129/Sv * 129S2/SvPas * C57BL/6	increased susceptibility to bacterial infection	J:112400
Casp1^tm1Sesh/Casp1^tm1Sesh Casp4^del/Casp4^del Slc11a1^s/Slc11a1^s B6.129S2-Casp1^tm1Sesh Casp4^del	abnormal macrophage physiology	J:112400
	increased susceptibility to bacterial infection	J:112400
Casp1^tm1Sesh/Casp1^tm1Sesh Casp4^del/Casp4^del Tg(Casp4)#Gne/0 involves: 129S2/SvPas * C57BL/6 * NOD/ShiLtJ	decreased circulating interleukin-1 beta level	J:193522
	decreased circulating interleukin-18 level	J:193522
	decreased interleukin-1 alpha secretion	J:193522
	decreased interleukin-1 beta secretion	J:193522
	decreased interleukin-18 secretion	J:193522
	decreased macrophage apoptosis	J:193522
	decreased susceptibility to endotoxin shock	J:193522
Casp1^tm1Sesh/Casp1^tm1Sesh Nlrp1a^Neut1/Nlrp1a^Neut1 involves: 129S2/SvPas * C57BL/6	normal immune system phenotype	J:191055
	increased circulating interleukin-18 level	J:191055

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 05/14/2024 MGI 6.23