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Rbpj Gene Detail
Summary
  • Symbol
    Rbpj
  • Name
    recombination signal binding protein for immunoglobulin kappa J region
  • Synonyms
    CBF1, Igkjrb, Igkrsbp, RBPjk, RBP-J kappa, Rbpsuh
  • Feature Type
    protein coding gene
  • IDs
    MGI:96522
    NCBI Gene: 19664
  • Gene Overview
    MyGene.info: RBPJ
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr5:53466152-53657362 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      191211 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 29.37 cM, cytoband C1-C3
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    RBPJ, recombination signal binding protein for immunoglobulin kappa J region
  • Vertebrate Orthologs
    10
  • Human Ortholog
    RBPJ, recombination signal binding protein for immunoglobulin kappa J region
    Orthology source: HomoloGene, HGNC
  • Synonyms
    AOS3, CBF1, csl, IGKJRB, IGKJRB1, KBF2, RBP-J, RBPJK, RBPSUH, SUH
  • Links
    NCBI Gene ID: 3516
    neXtProt AC: NX_Q06330
    UniProt: Q06330

  • Chr Location
    4p15.2; chr4:26163489-26435131 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 7511
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: RBPJ
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with human RBPJ associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    102 phenotypes from 7 alleles in 17 genetic backgrounds
    21 phenotypes from multigenic genotypes
    286 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit complete prenatal lethality.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000054613 VEGA Gene Model | MGI Sequence Detail 191211 C57BL/6J ±  kb
    transcript OTTMUST00000135387 VEGA | MGI Sequence Detail 5459 Not Applicable  
    polypeptide OTTMUSP00000071650 VEGA | MGI Sequence Detail 526 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      928 from dbSNP Build 142
    • PCR
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 38
      Genomic 2
      cDNA 26
      Primer pair 8
      Other 2

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGD-MRK-11327, MGI:2140979
    References
    more
    • Summaries
      All 412
      Developmental Gene Expression 66
      Gene Ontology 48
      Phenotypes 286
    • Earliest
      J:5021 Batchelor AL, et al., A comparison of the mutagenic effectiveness of chronic neutron- and gamma-irradiation of mouse spermatogonia. Mutat Res. 1966 Jun;3(3):218-29
    • Latest
      J:262627 Miao L, et al., Notch signaling regulates Hey2 expression in a spatiotemporal dependent manner during cardiac morphogenesis and trabecular specification. Sci Rep. 2018 Feb 8;8(1):2678

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
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    last database update
    07/31/2018
    MGI 6.12
    The Jackson Laboratory