About   Help   FAQ
Rbpj
Gene Detail
Symbol

Name
ID
Rbpj
recombination signal binding protein for immunoglobulin kappa J region
MGI:96522
Synonyms
CBF1, Igkjrb, Igkrsbp, RBPjk, RBP-J kappa, Rbpsuh
Feature Type
protein coding gene
Genetic Map
Chromosome 5
29.37 cM, cytoband C1-C3
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr5:53555779-53657445 bp, + strand
From Ensembl annotation of GRCm38

  101667 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7511  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: RBPJ
Gene Tree: Rbpj

Human
homologs
RBPJ, recombination signal binding protein for immunoglobulin kappa J region
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 3516
neXtProt AC: NX_Q06330

Human Synonyms: AOS3, CBF1, csl, IGKJRB, IGKJRB1, KBF2, RBP-J, RBPJK, RBPSUH, SUH

Human Chr (Location): 4p15.2; chr4:26163494-26435131 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human RBPJ

Mutations,
alleles, and
phenotypes
All mutations/alleles(312) : Gene trapped(299) Radiation induced(1) Targeted(12)
Genomic Mutations involving Rbpj (1)
Incidental mutations (data from CvDC )
 
Mice homozygous for a null allele exhibit complete prenatal lethality.
 
Phenotype Images(4)
Interactions
Rbpj interacts with 378 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (118 annotations)
Process angiogenesis, arterial endothelial cell fate commitment, ...
Component cell, cytoplasm, ...
Function chromatin binding, DNA binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (54 records)
Data Summary: Results (121)    Tissues (55)    Images (19)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 9
RNA in situ 46
Western blot 11
RT-PCR 55
cDNA source data(24)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase rbpj ; ZFIN rbpja, rbpjb    NEW 
Molecular
reagents
All nucleic(37) Genomic(2) cDNA(25) Primer pair(8) Other(2)
Microarray probesets(7)
Other database
links
Ensembl Gene Model ENSMUSG00000039191 (Evidence)
Entrez Gene 19664 (Evidence)
DFCI TC1617382, TC1665542, TC1590271, TC1634503, TC1572679, TC1706059
DoTS DT.101228429, DT.97408414, DT.91347531, DT.532648, DT.87042227, DT.110680907, DT.101738037
NIA Mouse Gene Index U042636, U027256, U175839
PDB 3BRG, 3IAG, 4J2X
Consensus CDS Project CCDS19292.1, CCDS51503.1, CCDS51504.1
International Mouse Phenotyping Consortium Status Rbpj
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000039191 Ensembl Gene Model | MGI Sequence Detail 101667 C57BL/6J ±  kb
transcript ENSMUST00000037618 Ensembl | MGI Sequence Detail 5541 Not Applicable 
polypeptide ENSMUSP00000040694 Ensembl | MGI Sequence Detail 526 Not Applicable 

For the selected sequences
All sequences(87) RefSeq(14) UniProt(5)
Polymorphisms
PCR(1) : SNPs within 2kb(409 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR015350 Beta-trefoil DNA-binding domain
InterPro IPR002909 Cell surface receptor IPT/TIG
InterPro IPR014756 Immunoglobulin E-set
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR015351 LAG1, DNA binding
InterPro IPR008967 p53-like transcription factor, DNA-binding
Protein Ontology PR:000013824 recombining binding protein suppressor of hairless
References
(Earliest) J:8644 Siminovitch KA, et al., The human kappa deleting element and the mouse recombining segment share DNA sequence homology. Nucleic Acids Res. 1987 Mar 25;15(6):2699-705
(Latest) J:221657 Kong JH, et al., Notch activity modulates the responsiveness of neural progenitors to sonic hedgehog signaling. Dev Cell. 2015 May 26;33(4):373-87
All references(292)
Other
accession IDs
MGD-MRK-11327, MGI:2140979

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
07/21/2015
MGI 5.22
The Jackson Laboratory