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Rbpj
Gene Detail
Symbol

Name
ID
Rbpj
recombination signal binding protein for immunoglobulin kappa J region
MGI:96522
Synonyms
CBF1, Igkjrb, Igkrsbp, RBPjk, RBP-J kappa, Rbpsuh
Feature Type
protein coding gene
Genetic Map
Chromosome 5
29.37 cM, cytoband C1-C3
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr5:53555779-53657445 bp, + strand
From Ensembl annotation of GRCm38

  101667 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7511  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Rbpj

Human
homologs
Human Homolog RBPJ, recombination signal binding protein for immunoglobulin kappa J region
NCBI Gene ID 3516
neXtProt AC  NX_Q06330
Human Synonyms  AOS3, CBF1, csl, IGKJRB, IGKJRB1, KBF2, RBP-J, RBPJK, RBPSUH, SUH
Human Chr (Location)  4p15.2; chr4:26163494-26435131 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human RBPJ
Mutations,
alleles, and
phenotypes
All mutations/alleles(308) : Gene trapped(299) Targeted(9)
 
Homozygous null mutants show retarded growth, incomplete turning, microencephaly, placenta defects and die by midgestation. Heterozygotes have learning/memory defects. Conditional mutants lack marginal zone B cells, show hair loss and epidermal defects.
 
Interactions
Rbpj interacts with 378 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (110 annotations)
Process angiogenesis, arterial endothelial cell fate commitment, ...
Component cell, cytoplasm, ...
Function chromatin binding, DNA binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (53 records)
Data Summary: Results (121)    Tissues (55)    Images (19)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 9
RNA in situ 46
Western blot 11
RT-PCR 55
cDNA source data(24)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(37) Genomic(2) cDNA(25) Primer pair(8) Other(2)
Microarray probesets(7)
Other database
links
Ensembl Gene ModelENSMUSG00000039191 (Evidence)
Entrez Gene19664 (Evidence)
DFCITC1572679, TC1665542, TC1634503, TC1617382, TC1590271, TC1706059
DoTSDT.532648, DT.110680907, DT.101738037, DT.101228429, DT.87042227, DT.97408414, DT.91347531
NIA Mouse Gene IndexU175839, U042636, U027256
PDB4J2X, 3IAG, 3BRG
Consensus CDS ProjectCCDS19292.1, CCDS51503.1, CCDS51504.1
International Mouse Knockout Project StatusRbpj
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000039191 Ensembl Gene Model | MGI Sequence Detail 101667 C57BL/6J ±  kb
transcript ENSMUST00000037618 Ensembl | MGI Sequence Detail 5541 Not Applicable 
polypeptide ENSMUSP00000040694 Ensembl | MGI Sequence Detail 526 Not Applicable 

For the selected sequences
All sequences(95) RefSeq(18) UniProt(9)
Polymorphisms
PCR(1) : SNPs within 2kb(409 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR015350 Beta-trefoil DNA-binding domain
InterPro IPR002909 Cell surface receptor IPT/TIG
InterPro IPR014756 Immunoglobulin E-set
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR015351 LAG1, DNA binding
InterPro IPR008967 p53-like transcription factor, DNA-binding
Protein Ontology PR:000013824 recombining binding protein suppressor of hairless
References
(Earliest) J:8644 Siminovitch KA, et al., The human kappa deleting element and the mouse recombining segment share DNA sequence homology. Nucleic Acids Res. 1987 Mar 25;15(6):2699-705
(Latest) J:214450 Yimlamai D, et al., Hippo pathway activity influences liver cell fate. Cell. 2014 Jun 5;157(6):1324-38
All references(277)
Other
accession IDs
MGD-MRK-11327, MGI:2140979

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/16/2014
MGI 5.20
The Jackson Laboratory