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Rbpj
Gene Detail
 Symbol
Name
ID
Rbpj
recombination signal binding protein for immunoglobulin kappa J region
MGI:96522
Synonyms CBF1, Igkjrb, Igkrsbp, RBPjk, RBP-J kappa, Rbpsuh
Feature Type protein coding gene
Genetic Map
Chromosome 5
29.37 cM, cytoband C1-C3
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr5:53590215-53657445 bp, + strand
From NCBI annotation of GRCm38

  67231 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7511  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Rbpj

Human
homologs
Human Homolog RBPJ, recombination signal binding protein for immunoglobulin kappa J region
NCBI Gene ID 3516
neXtProt AC  NX_Q06330
Human Synonyms  AOS3, CBF1, csl, IGKJRB, IGKJRB1, KBF2, RBP-J, RBPJK, RBPSUH, SUH
Human Chr (Location)  4p15.2; chr4:26163494-26435131 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human RBPJ
Alleles
and
phenotypes
All alleles(106) : Targeted(8) Gene trapped(98)
 
Homozygous null mutants show retarded growth, incomplete turning, microencephaly, placenta defects and die by midgestation. Heterozygotes have learning/memory defects. Conditional mutants lack marginal zone B cells, show hair loss and epidermal defects.
 
Gene Ontology
(GO)
classifications
All GO classifications: (100 annotations)
Process angiogenesis, arterial endothelial cell fate commitment, ...
Component cell, cytoplasm, ...
Function chromatin binding, DNA binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (49 records)
Data Summary: Results (130)    Tissues (58)    Images (19)
Theiler Stages: 1, 2, 3, 4, 5, 11, 13, 15, 17, 19, 20, 22, 23, 24, 26, 28
Assay TypeResults
Immunohistochemistry 9
RNA in situ 46
Western blot 11
RT-PCR 64
cDNA source data(24)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(37) Genomic(2) cDNA(25) Primer pair(8) Other(2)
Microarray probesets(7)
Other database
links
Ensembl Gene ModelENSMUSG00000039191 (Evidence)
Entrez Gene19664 (Evidence)
DFCITC1572679, TC1590271, TC1617382, TC1634503, TC1665542, TC1706059
DoTSDT.101228429, DT.101738037, DT.110680907, DT.532648, DT.87042227, DT.91347531, DT.97408414
NIA Mouse Gene IndexU027256, U042636, U175839
PDB3BRG, 3IAG, 4J2X
Consensus CDS ProjectCCDS19292.1, CCDS51503.1, CCDS51504.1
International Mouse Knockout Project StatusRbpj
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 19664 NCBI Gene Model | MGI Sequence Detail 67231 C57BL/6J ±  kb
transcript NM_001277116 RefSeq | MGI Sequence Detail 5590 C57BL/6 
polypeptide P31266 UniProt | EBI | MGI Sequence Detail 526 Not Applicable 

For the selected sequences
All sequences(91) RefSeq(18) UniProt(5)
Polymorphisms PCR(1) : SNPs within 2kb(409 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR015350 Beta-trefoil DNA-binding domain
InterPro IPR002909 Cell surface receptor IPT/TIG
InterPro IPR014756 Immunoglobulin E-set
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR015351 LAG1, DNA binding
InterPro IPR008967 p53-like transcription factor, DNA-binding
Protein Ontology PR:000013824 recombining binding protein suppressor of hairless
Graphical View of Protein Domain Structure
References (Earliest) J:8644 Siminovitch KA, et al., The human kappa deleting element and the mouse recombining segment share DNA sequence homology. Nucleic Acids Res. 1987 Mar 25;15(6):2699-705
(Latest) J:206586 Boyle SC, et al., Notch signaling is required for the formation of mesangial cells from a stromal mesenchyme precursor during kidney development. Development. 2014 Jan;141(2):346-54
All references(254)
Other
accession IDs
MGD-MRK-11327, MGI:2140979

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory