About   Help   FAQ
Idh1
Gene Detail
 Symbol
Name
ID
Idh1
isocitrate dehydrogenase 1 (NADP+), soluble
MGI:96413
Synonyms E030024J03Rik, Id-1, Idh-1, IDPc
Feature Type protein coding gene
Genetic Map
Chromosome 1
32.91 cM
Detailed Genetic Map ± 1 cM


Mapping data(95)
Sequence Map
Chr1:65158616-65186500 bp, - strand
From VEGA annotation of GRCm38

  27885 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:21195  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 chicken; 1 zebrafish

Protein SuperFamily: isocitrate dehydrogenase (NADP)
Gene Tree: Idh1

Human
homologs
Human Homolog IDH1, isocitrate dehydrogenase 1 (NADP+), soluble
NCBI Gene ID 3417
neXtProt AC  NX_O75874
Human Synonyms  HEL-216, HEL-S-26, IDCD, IDH, IDP, IDPC, PICD
Human Chr (Location)  2q33.3; chr2:208236227-208255143 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human IDH1
Mutations,
alleles, and
phenotypes
All mutations/alleles(22) : Gene trapped(14) Targeted(8)
Incidental mutations (data from Mutagenetix , APF )
 
Electrophoretic variation has been shown in tissues of liver, kidney, spleen and muscle. Strains C57BL/6, C3H/He carry the a allele; DBA/2 carries the b allele; M.m. castaneus and M.m. molossinus carry the c allele; the d allele is found at low frequency in M. m. molossinus in Japan.
 
Interactions
Idh1 interacts with 150 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (28 annotations)
Process 2-oxoglutarate metabolic process, glutathione metabolic process, ...
Component cytoplasm, cytosol, ...
Function isocitrate dehydrogenase (NADP+) activity, magnesium ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (351)    Tissues (154)    Images (54)
Theiler Stages: 22, 23, 26, 28
Assay TypeResults
RNA in situ 351
cDNA source data(17)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(17) cDNA(17)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000021898 (Evidence)
Ensembl Gene ModelENSMUSG00000025950 (Evidence)
Entrez Gene15926 (Evidence)
DFCITC1573539, TC1683672, TC1691717, TC1738050
DoTSDT.102557514, DT.536647, DT.91293161, DT.97355719, DT.99860968
NIA Mouse Gene IndexU021417
EC1.1.1.42
PDB2CMJ, 2CMV
Consensus CDS ProjectCCDS15016.1
International Mouse Knockout Project StatusIdh1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021898 VEGA Gene Model | MGI Sequence Detail 27885 C57BL/6J ±  kb
transcript OTTMUST00000052006 VEGA | MGI Sequence Detail 2302 Not Applicable 
polypeptide OTTMUSP00000024561 VEGA | MGI Sequence Detail 414 Not Applicable 

For the selected sequences
All sequences(59) RefSeq(4) UniProt(6)
Polymorphisms SNPs within 2kb(195 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR004790 Isocitrate dehydrogenase NADP-dependent
InterPro IPR019818 Isocitrate/isopropylmalate dehydrogenase, conserved site
InterPro IPR024084 Isopropylmalate dehydrogenase-like domain
Protein Ontology PR:000008887 isocitrate dehydrogenase [NADP] cytoplasmic
References (Earliest) J:13010 HENDERSON NS, ISOZYMES OF ISOCITRATE DEHYDROGENASE: SUBUNIT STRUCTURE AND INTRACELLULAR LOCATION. J Exp Zool. 1965 Apr;158:263-73
(Latest) J:198193 Rohle D, et al., An inhibitor of mutant IDH1 delays growth and promotes differentiation of glioma cells. Science. 2013 May 3;340(6132):626-30
All references(140)
Other
accession IDs
MGD-MRK-11152, MGD-MRK-11180, MGD-MRK-11183, MGI:2138196, MGI:2138322

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/19/2014
MGI 5.19
The Jackson Laboratory