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Idh1 Gene Detail
Summary
  • Symbol
    Idh1
  • Name
    isocitrate dehydrogenase 1 (NADP+), soluble
  • Synonyms
    E030024J03Rik, Id-1, Idh-1, IDPc
  • Feature Type
    protein coding gene
  • IDs
    MGI:96413
    NCBI Gene: 15926
  • Gene Overview
    MyGene.info: IDH1
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:65158616-65186479 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 32.91 cM
  • Mapping Data
    95 experiments
Strain
Comparison
more
  • SNPs within 2kb
    195 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96413
 protein coding gene Chr1:65158616-65186500 (-)
129S1/SvImJ MGP_129S1SvImJ_G0016108
 protein coding gene Chr1:65359110-65387031 (-)
A/J MGP_AJ_G0016091
 protein coding gene Chr1:63052068-63079940 (-)
AKR/J MGP_AKRJ_G0016048
 protein coding gene Chr1:64816106-64843926 (-)
BALB/cJ MGP_BALBcJ_G0016046
 protein coding gene Chr1:63150191-63178082 (-)
C3H/HeJ MGP_C3HHeJ_G0015877
 protein coding gene Chr1:65092212-65120925 (-)
C57BL/6NJ MGP_C57BL6NJ_G0016499
 protein coding gene Chr1:67879085-67910344 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014220
 protein coding gene Chr1:59100154-59126298 (-)
CAST/EiJ MGP_CASTEiJ_G0015461
 protein coding gene Chr1:64361595-64389996 (-)
CBA/J MGP_CBAJ_G0015850
 protein coding gene Chr1:70077827-70105674 (-)
DBA/2J MGP_DBA2J_G0015951
 protein coding gene Chr1:62452916-62480942 (-)
FVB/NJ MGP_FVBNJ_G0015954
 protein coding gene Chr1:61728037-61755892 (-)
LP/J MGP_LPJ_G0016023
 protein coding gene Chr1:66254256-66281968 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0015974
 protein coding gene Chr1:72944449-72973626 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0016546
 protein coding gene Chr1:64816241-64844489 (-)
PWK/PhJ MGP_PWKPhJ_G0015247
 protein coding gene Chr1:61851071-61879078 (-)
SPRET/EiJ MGP_SPRETEiJ_G0015027
 protein coding gene Chr1:64288812-64318851 (-)
WSB/EiJ MGP_WSBEiJ_G0015523
 protein coding gene Chr1:64518196-64546082 (-)



Homology
more
  • Human Ortholog
    IDH1, isocitrate dehydrogenase (NADP(+)) 1, cytosolic
  • Vertebrate Orthologs
    9
  • Human Ortholog
    IDH1, isocitrate dehydrogenase (NADP(+)) 1, cytosolic
    Orthology source: HomoloGene, HGNC
  • Synonyms
    HEL-216, HEL-S-26, IDCD, IDH, IDP, IDPC, PICD
  • Links
    NCBI Gene ID: 3417
    neXtProt AC: NX_O75874
    UniProt: O75874

  • Chr Location
    2q34; chr2:208236227-208255143 (-)  GRCh38.p7
Human Diseases
more
  • Diseases
    1 with human IDH1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    29 phenotypes from 4 alleles in 6 genetic backgrounds
    23 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Electrophoretic variation has been shown in tissues of liver, kidney, spleen and muscle. Strains C57BL/6, C3H/He carry the a allele; DBA/2 carries the b allele; M.m. castaneus and M.m. molossinus carry the c allele; the d allele is found at low frequencyin M. m. molossinus in Japan.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    39
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    351
  • Tissues
    154
  • cDNA Data
    18
  • Literature Summary
    10
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 15926 NCBI Gene Model | MGI Sequence Detail 27864 C57BL/6J ±  kb
    transcript NM_001111320 RefSeq | MGI Sequence Detail 2292 C57BL/6  
    polypeptide O88844 UniProt | EBI | MGI Sequence Detail 414 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 18
      cDNA 18

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-11152, MGD-MRK-11180, MGD-MRK-11183, MGI:2138196, MGI:2138322
    References
    more
    • Summaries
      All 159
      Developmental Gene Expression 10
      Gene Ontology 11
      Phenotypes 23
    • Earliest
      J:13010 HENDERSON NS, ISOZYMES OF ISOCITRATE DEHYDROGENASE: SUBUNIT STRUCTURE AND INTRACELLULAR LOCATION. J Exp Zool. 1965 Apr;158:263-73
    • Latest
      J:267504 Kiyama T, et al., Essential roles of mitochondrial biogenesis regulator Nrf1 in retinal development and homeostasis. Mol Neurodegener. 2018 Oct 17;13(1):56
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/09/2019
    MGI 6.13     		The Jackson Laboratory