Idh1
Gene Detail

Symbol Name ID

Idh1 isocitrate dehydrogenase 1 (NADP+), soluble MGI:96413

Synonyms

E030024J03Rik, Id-1, Idh-1, IDPc

Feature Type

protein coding gene

Genetic Map

Chromosome 1

32.91 cM
Detailed Genetic Map ± 1 cM


Mapping data(95)

Sequence Map

Chr1:65158616-65179181 bp, - strand From VEGA annotation of GRCm38   20566 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:21195  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 chicken; 1 zebrafish

Protein SuperFamily: isocitrate dehydrogenase (NADP)
Gene Tree: Idh1

Human homologs

Human Homolog		IDH1, isocitrate dehydrogenase 1 (NADP+), soluble
NCBI Gene ID		3417
neXtProt AC		NX_O75874
Human Synonyms		HEL-216, HEL-S-26, IDCD, IDH, IDP, IDPC, PICD
Human Chr (Location)		2q33.3; chr2:208236227-208255143 (-)  GRCh38
Disease Associations		(1) Diseases Associated with Human IDH1

Mutations, alleles, and phenotypes

All mutations/alleles(20) : Gene trapped(12) Targeted(8)
Incidental mutations (data from Mutagenetix , APF )
 

Electrophoretic variation has been shown in tissues of liver, kidney, spleen and muscle. Strains C57BL/6, C3H/He carry the a allele; DBA/2 carries the b allele; M.m. castaneus and M.m. molossinus carry the c allele; the d allele is found at low frequency in M. m. molossinus in Japan.

 

Interactions

Idh1 interacts with 150 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)

View All

Gene Ontology (GO) classifications

All GO classifications: (28 annotations)

Process	2-oxoglutarate metabolic process, glutathione metabolic process, ...
Component	cytoplasm, cytosol, ...
Function	isocitrate dehydrogenase (NADP+) activity, magnesium ion binding, ...

External Resources: FuncBase

Expression

Literature Summary: (6 records)

Data Summary: Results (351)    Tissues (154)    Images (54)
Theiler Stages: 22, 23, 26, 28

Assay Type	Results
RNA in situ	351

cDNA source data(17)
External Resources: Allen Institute   GEO   Expression Atlas

Molecular reagents

All nucleic(17) cDNA(17)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000021898 (Evidence)
Ensembl Gene Model	ENSMUSG00000025950 (Evidence)
Entrez Gene	15926 (Evidence)
DFCI	TC1573539, TC1683672, TC1691717, TC1738050
DoTS	DT.102557514, DT.536647, DT.91293161, DT.97355719, DT.99860968
NIA Mouse Gene Index	U021417
EC	1.1.1.42
PDB	2CMJ, 2CMV
Consensus CDS Project	CCDS15016.1
International Mouse Knockout Project Status	Idh1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000021898	VEGA Gene Model | MGI Sequence Detail	20566	C57BL/6J
transcript	OTTMUST00000052006	VEGA | MGI Sequence Detail	2302	Not Applicable
polypeptide	OTTMUSP00000024561	VEGA | MGI Sequence Detail	414	Not Applicable

All sequences(51) RefSeq(4) UniProt(6)

Polymorphisms

SNPs within 2kb(195 from dbSNP Build 137)

Protein-related information

Resource	ID	Description
InterPro	IPR004790	Isocitrate dehydrogenase NADP-dependent
InterPro	IPR019818	Isocitrate/isopropylmalate dehydrogenase, conserved site
InterPro	IPR024084	Isopropylmalate dehydrogenase-like domain
Protein Ontology	PR:000008887	isocitrate dehydrogenase [NADP] cytoplasmic

References

(Earliest) J:13010 HENDERSON NS, ISOZYMES OF ISOCITRATE DEHYDROGENASE: SUBUNIT STRUCTURE AND INTRACELLULAR LOCATION. J Exp Zool. 1965 Apr;158:263-73
(Latest) J:198193 Rohle D, et al., An inhibitor of mutant IDH1 delays growth and promotes differentiation of glioma cells. Science. 2013 May 3;340(6132):626-30
All references(140)

Other accession IDs

MGD-MRK-11152, MGD-MRK-11180, MGD-MRK-11183, MGI:2138196, MGI:2138322