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Idh1
Gene Detail
Symbol

Name
ID
Idh1
isocitrate dehydrogenase 1 (NADP+), soluble
MGI:96413
Synonyms
E030024J03Rik, Id-1, Idh-1, IDPc
Feature Type
protein coding gene
Genetic Map
Chromosome 1
32.91 cM
Detailed Genetic Map ± 1 cM


Mapping data(95)
Sequence Map
Chr1:65158616-65186500 bp, - strand
From VEGA annotation of GRCm38

  27885 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:21195  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

HCOP human homology predictions: IDH1
Protein SuperFamily: isocitrate dehydrogenase (NADP)
Gene Tree: Idh1

Human
homologs
IDH1, isocitrate dehydrogenase 1 (NADP+), soluble
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 3417
neXtProt AC: NX_O75874

Human Synonyms: HEL-216, HEL-S-26, IDCD, IDH, IDP, IDPC, PICD

Human Chr (Location): 2q33.3; chr2:208236227-208255143 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human IDH1

Mutations,
alleles, and
phenotypes
All mutations/alleles(23) : Gene trapped(14) Targeted(9)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Electrophoretic variation has been shown in tissues of liver, kidney, spleen and muscle. Strains C57BL/6, C3H/He carry the a allele; DBA/2 carries the b allele; M.m. castaneus and M.m. molossinus carry the c allele; the d allele is found at low frequency in M. m. molossinus in Japan.
 
Interactions
Idh1 interacts with 150 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (30 annotations)
Process 2-oxoglutarate metabolic process, glutathione metabolic process, ...
Component cytoplasm, cytosol, ...
Function isocitrate dehydrogenase (NADP+) activity, magnesium ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (351)    Tissues (154)    Images (54)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 351
cDNA source data(17)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase idh1 ; ZFIN idh1    NEW 
Molecular
reagents
All nucleic(17) cDNA(17)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000021898 (Evidence)
Ensembl Gene Model ENSMUSG00000025950 (Evidence)
Entrez Gene 15926 (Evidence)
DFCI TC1573539, TC1683672, TC1691717, TC1738050
DoTS DT.102557514, DT.536647, DT.91293161, DT.97355719, DT.99860968
NIA Mouse Gene Index U021417
EC 1.1.1.42
PDB 2CMJ, 2CMV
Consensus CDS Project CCDS15016.1
International Mouse Phenotyping Consortium Status Idh1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021898 VEGA Gene Model | MGI Sequence Detail 27885 C57BL/6J ±  kb
transcript OTTMUST00000052006 VEGA | MGI Sequence Detail 2302 Not Applicable 
polypeptide OTTMUSP00000024561 VEGA | MGI Sequence Detail 414 Not Applicable 

For the selected sequences
All sequences(72) RefSeq(4) UniProt(10)
Polymorphisms
SNPs within 2kb(195 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR004790 Isocitrate dehydrogenase NADP-dependent
InterPro IPR019818 Isocitrate/isopropylmalate dehydrogenase, conserved site
InterPro IPR024084 Isopropylmalate dehydrogenase-like domain
Protein Ontology PR:000008887 isocitrate dehydrogenase [NADP] cytoplasmic
References
(Earliest) J:13010 HENDERSON NS, ISOZYMES OF ISOCITRATE DEHYDROGENASE: SUBUNIT STRUCTURE AND INTRACELLULAR LOCATION. J Exp Zool. 1965 Apr;158:263-73
(Latest) J:220318 Hirata M, et al., Mutant IDH is sufficient to initiate enchondromatosis in mice. Proc Natl Acad Sci U S A. 2015 Mar 3;112(9):2829-34
All references(139)
Other
accession IDs
MGD-MRK-11152, MGD-MRK-11180, MGD-MRK-11183, MGI:2138196, MGI:2138322

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/20/2015
MGI 5.22
The Jackson Laboratory