Htr2c
Gene Detail

Symbol Name ID

Htr2c 5-hydroxytryptamine (serotonin) receptor 2C MGI:96281

Synonyms

5HT1c, 5-HT2cR, 5-HT2C receptor, Htr1c, SR1

Feature Type

protein coding gene

Genetic Map

Chromosome X

68.46 cM, cytoband D-F4
Detailed Genetic Map ± 1 cM


Mapping data(10)

Sequence Map

ChrX:146962513-147197277 bp, + strand From VEGA annotation of GRCm38   234765 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:20242  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: 5-hydroxytryptamine receptor 2
Gene Tree: Htr2c

Human homologs

Human Homolog		HTR2C, 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled
NCBI Gene ID		3358
neXtProt AC		NX_P28335
Human Synonyms		5-HT2C, 5-HTR2C, HTR1C
Human Chr (Location)		Xq24; chrX:113818551-114144624 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(8) : Targeted(8)
 

Homozygotes for a targeted null mutation exhibit hyperactivity, hyperphagia, reduced energy cost of locomotion, late-onset obesity, insulin resistance, and altered responses to cocaine. Mutants are also subject to spontaneous death from seizures.

 
Human Diseases Modeled Using Mouse Htr2c (2)    Alleles Annotated to Human Diseases(2)   

Gene Ontology (GO) classifications

All GO classifications: (45 annotations)

Process	behavior, behavioral response to nicotine, ...
Component	cell surface, external side of plasma membrane, ...
Function	1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding, drug binding, ...

External Resources: FuncBase

Expression

Literature Summary: (5 records)
Data Summary: Results (121)    Tissues (68)    Images (11)
Theiler Stages: 12, 14, 16, 19, 21, 23, 28

Assay Type	Results
RNA in situ	25
RT-PCR	96

cDNA source data(8)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(15) Genomic(2) cDNA(11) Primer pair(2)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000018943 (Evidence)
Ensembl Gene Model	ENSMUSG00000041380 (Evidence)
Entrez Gene	15560 (Evidence)
UniGene	439670
DFCI	TC1588304, TC1649837
DoTS	DT.101724063, DT.111022405, DT.91336547
NIA Mouse Gene Index	U020295
Consensus CDS Project	CCDS30459.1
International Mouse Knockout Project Status	Htr2c

Sequences

Length	Strain/Species
genomic	OTTMUSG00000018943	VEGA Gene Model | MGI Sequence Detail	234765	C57BL/6J
transcript	OTTMUST00000045515	VEGA | MGI Sequence Detail	4883	Not Applicable
polypeptide	OTTMUSP00000020457	VEGA | MGI Sequence Detail	459	Not Applicable

All sequences(46) RefSeq(2) UniProt(4)

Polymorphisms

SNPs(503 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000377	5-Hydroxytryptamine 2C receptor
InterPro	IPR002231	5-Hydroxytryptamine receptor
InterPro	IPR000276	GPCR, rhodopsin-like
InterPro	IPR017452	GPCR, rhodopsin-like, 7TM
Protein Ontology	PR:000001168	5-hydroxytryptamine receptor 2C

References

(Earliest) J:40017 Lubbert H, et al., cDNA cloning of a serotonin 5-HT1C receptor by electrophysiological assays of mRNA-injected Xenopus oocytes. Proc Natl Acad Sci U S A. 1987 Jun;84(12):4332-6
(Latest) J:190498 Telegdy G, et al., Neurotransmitter-mediated action of an antagonist of growth hormone-releasing hormone on anxiolysis in mice. Behav Brain Res. 2012 Jul 15;233(1):232-6
All references(93)

Other accession IDs

MGD-MRK-11001, MGD-MRK-11008, MGI:96275