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Htr2c
Gene Detail
Symbol

Name
ID
Htr2c
5-hydroxytryptamine (serotonin) receptor 2C
MGI:96281
Synonyms
5HT1c, 5-HT2cR, 5-HT2C receptor, Htr1c, SR1
Feature Type
protein coding gene
Genetic Map
Chromosome X
68.46 cM, cytoband D-F4
Detailed Genetic Map ± 1 cM


Mapping data(10)
Sequence Map
ChrX:146962513-147197277 bp, + strand
From VEGA annotation of GRCm38

  234765 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20242  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

HCOP human homology predictions: HTR2C
Protein SuperFamily: 5-hydroxytryptamine receptor 2
Gene Tree: Htr2c

Human
homologs
HTR2C, 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 3358
neXtProt AC: NX_P28335

Human Synonyms: 5-HT1C, 5-HT2C, 5HTR2C, 5-HTR2C, HTR1C

Human Chr (Location): Xq24; chrX:114584078-114910061 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(9) : Targeted(9)
 
Homozygotes for a targeted null mutation exhibit hyperactivity, hyperphagia, reduced energy cost of locomotion, late-onset obesity, insulin resistance, and altered responses to cocaine. Mutants are also subject to spontaneous death from seizures.
 
Human Diseases Modeled in Mice Using Htr2c (2)    Mutations Annotated to Human Diseases (2)   
Interactions
Htr2c interacts with 411 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (55 annotations)
Process behavior, behavioral fear response, ...
Component cell, cell surface, ...
Function 1-(4-iodo-2,5-dimethoxyphenyl)propan-2-amine binding, drug binding, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (121)    Tissues (68)    Images (11)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 25
RT-PCR 96
cDNA source data(8)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase htr2c    NEW 
Molecular
reagents
All nucleic(15) Genomic(2) cDNA(11) Primer pair(2)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000018943 (Evidence)
Ensembl Gene Model ENSMUSG00000041380 (Evidence)
Entrez Gene 15560 (Evidence)
UniGene 439670
DFCI TC1588304, TC1649837
DoTS DT.101724063, DT.111022405, DT.91336547
NIA Mouse Gene Index U020295
Consensus CDS Project CCDS30459.1
International Mouse Phenotyping Consortium Status Htr2c
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000018943 VEGA Gene Model | MGI Sequence Detail 234765 C57BL/6J ±  kb
transcript OTTMUST00000045548 VEGA | MGI Sequence Detail 4747 Not Applicable 
polypeptide OTTMUSP00000020482 VEGA | MGI Sequence Detail 459 Not Applicable 

For the selected sequences
All sequences(51) RefSeq(4) UniProt(5)
Polymorphisms
SNPs within 2kb(537 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000377 5-Hydroxytryptamine 2C receptor
InterPro IPR002231 5-hydroxytryptamine receptor family
InterPro IPR017452 GPCR, rhodopsin-like, 7TM
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
Protein Ontology PR:000001168 5-hydroxytryptamine receptor 2C
References
(Earliest) J:40017 Lubbert H, et al., cDNA cloning of a serotonin 5-HT1C receptor by electrophysiological assays of mRNA-injected Xenopus oocytes. Proc Natl Acad Sci U S A. 1987 Jun;84(12):4332-6
(Latest) J:209247 Nilsson SR, et al., Dissociable effects of 5-HT2C receptor antagonism and genetic inactivation on perseverance and learned non-reward in an egocentric spatial reversal task. PLoS One. 2013;8(10):e77762
All references(95)
Disease annotation references (2)
Other
accession IDs
MGD-MRK-11001, MGD-MRK-11008, MGI:96275

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory