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Htr2c Gene Detail
Summary
  • Symbol
    Htr2c
  • Name
    5-hydroxytryptamine (serotonin) receptor 2C
  • Synonyms
    5HT1c, 5-HT2cR, 5-HT2C receptor, Htr1c, SR1
  • Feature Type
    protein coding gene
  • IDs
    MGI:96281
    NCBI Gene: 15560
  • Gene Overview
    MyGene.info: HTR2C
Location & Maps
more
  • Sequence Map
    ChrX:146962513-147197277 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      234765 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome X, 68.46 cM, cytoband D-F4
  • Mapping Data
    10 experiments
Homology
more
  • Human Ortholog
    HTR2C, 5-hydroxytryptamine receptor 2C
  • Vertebrate Orthologs
    7
  • Human Ortholog
    HTR2C, 5-hydroxytryptamine receptor 2C
    Orthology source: HGNC, HomoloGene
  • Synonyms
    5-HT1C, 5-HT2C, 5HTR2C, 5-HTR2C, HTR1C
  • Links
    NCBI Gene ID: 3358
    neXtProt AC: NX_P28335

  • Chr Location
    Xq24; chrX:114584078-114910061 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    2 with Htr2c mouse models

Human Disease Mouse Models
       Diabetes Mellitus, Noninsulin-Dependent; NIDDM   OMIM: 125853 View 1 model
Prader-Willi Syndrome; PWS   OMIM: 176270 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    78 phenotypes from 8 alleles in 13 genetic backgrounds
    4 phenotypes from multigenic genotypes
    44 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    10
  • Targeted
    10
Homozygotes for a targeted null mutation exhibit hyperactivity, hyperphagia, reduced energy cost of locomotion, late-onset obesity, insulin resistance, and altered responses to cocaine. Mutants are also subject to spontaneous death from seizures.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000018943 VEGA Gene Model | MGI Sequence Detail 234765 C57BL/6J ±  kb
transcript OTTMUST00000045548 VEGA | MGI Sequence Detail 4747 Not Applicable  
polypeptide OTTMUSP00000020482 VEGA | MGI Sequence Detail 459 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    535 from dbSNP Build 142
Protein
Information
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  • UniProt
    5 Sequences
  • Protein Ontology
    PR:000001168 5-hydroxytryptamine receptor 2C
  • InterPro Domains
    IPR000377 5-Hydroxytryptamine 2C receptor
    IPR002231 5-hydroxytryptamine receptor family
    IPR017452 GPCR, rhodopsin-like, 7TM
    IPR000276 G protein-coupled receptor, rhodopsin-like
Molecular
Reagents
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  • All nucleic 15
    Genomic 2
    cDNA 11
    Primer pair 2

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-11001, MGD-MRK-11008, MGI:96275
References
more
  • Summaries
    All 94
    Developmental Gene Expression 5
    Diseases 2
    Gene Ontology 12
    Phenotypes 44
  • Earliest
    J:40017 Lubbert H, et al., cDNA cloning of a serotonin 5-HT1C receptor by electrophysiological assays of mRNA-injected Xenopus oocytes. Proc Natl Acad Sci U S A. 1987 Jun;84(12):4332-6
  • Latest
    J:226945 Carmody JS, et al., Weight Loss After RYGB Is Independent of and Complementary to Serotonin 2C Receptor Signaling in Male Mice. Endocrinology. 2015 Sep;156(9):3183-91

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory