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Hoxb9 Gene Detail
Summary
  • Symbol
    Hoxb9
  • Name
    homeobox B9
  • Synonyms
    Hox-2.5
  • Feature Type
    protein coding gene
  • IDs
    MGI:96190
    NCBI Gene: 15417
  • Member of
    Hoxb cluster
  • Gene Overview
    MyGene.info: HOXB9
Location & Maps
more
  • Sequence Map
    Chr11:96271457-96276595 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      5139 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 59.81 cM
  • Mapping Data
    9 experiments
Homology
more
  • Human Ortholog
    HOXB9, homeobox B9
  • Vertebrate Orthologs
    9
  • Human Ortholog
    HOXB9, homeobox B9
    Orthology source: HomoloGene
  • Synonyms
    HOX2, HOX-2.5, HOX2E
  • Links
    NCBI Gene ID: 3219
    neXtProt AC: NX_P17482

  • Chr Location
    17q21.3; chr17:48615128-48626473 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    7 phenotypes from 1 allele in 1 genetic background
    17 phenotypes from multigenic genotypes
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    6
  • Gene trapped
    1
  • Targeted
    5
  • Genomic Mutations
    3 involving Hoxb9
  • Incidental Mutations
    APF
Mutations affect developing thoracic skeletal elements. Homozygotes exhibit rib fusion, abnormal rib attachment to the sternum, and reduced intercostal segments of the sternum. Homozygotes or heterozygotes may show an eighth rib attached to the sternum.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000001991 VEGA Gene Model | MGI Sequence Detail 5139 C57BL/6J ±  kb
transcript OTTMUST00000003997 VEGA | MGI Sequence Detail 2574 Not Applicable  
polypeptide OTTMUSP00000001934 VEGA | MGI Sequence Detail 250 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    36 from dbSNP Build 142
  • PCR
Protein
Information
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Molecular
Reagents
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  • All nucleic 42
    Genomic 17
    cDNA 19
    Primer pair 5
    Other 1

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-10833, MGD-MRK-10891
References
more
  • Summaries
    All 92
    Developmental Gene Expression 54
    Gene Ontology 8
    Phenotypes 18
  • Earliest
    J:32282 Graham A, et al., Characterization of a murine homeo box gene, Hox-2.6, related to the Drosophila Deformed gene. Genes Dev. 1988 Nov;2(11):1424-38
  • Latest
    J:225537 Zhang J, et al., Ezh2 maintains retinal progenitor proliferation, transcriptional integrity, and the timing of late differentiation. Dev Biol. 2015 Jul 15;403(2):128-38

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory