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Hoxb8
Gene Detail
Symbol

Name
ID
Member of
Hoxb8
homeobox B8
MGI:96189
Hoxb cluster
Synonyms
Hox-2.4
Feature Type
protein coding gene
Genetic Map
Chromosome 11
59.82 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr11:96281905-96285315 bp, + strand
From VEGA annotation of GRCm38

  3411 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7768  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: HOXB8
Protein SuperFamily: homeotic protein Hox A5/D4
Gene Tree: Hoxb8

Human
homologs
HOXB8, homeobox B8
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 3218
neXtProt AC: NX_P17481

Human Synonyms: HOX2, Hox-2.4, HOX2D

Human Chr (Location): 17q21.3; chr17:48612346-48615112 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(12) : Targeted(12)
Genomic Mutations involving Hoxb8 (2)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Most homozygotes for targeted null mutations exhibit delayed preweaning growth, degeneration of the second spinal ganglion, axial skeletal defects, impaired clasping, an altered gait, and excessive grooming.
 
Human Diseases Modeled in Mice Using Hoxb8 (1)    Mutations Annotated to Human Diseases (1)   
Interactions
Hoxb8 interacts with 198 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (24 annotations)
Process adult locomotory behavior, anterior/posterior pattern specification, ...
Component nucleus
Function DNA binding, sequence-specific DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (67 records)
Data Summary: Results (254)    Tissues (158)    Images (62)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 225
In situ reporter (knock in) 13
Northern blot 6
RT-PCR 6
RNase protection 4
cDNA source data(12)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA HOXB8 ; Xenbase hoxb8 ; ZFIN hoxb8a, hoxb8b    NEW 
Molecular
reagents
All nucleic(27) Genomic(12) cDNA(13) Primer pair(1) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000001990 (Evidence)
Ensembl Gene Model ENSMUSG00000056648 (Evidence)
Entrez Gene 15416 (Evidence)
UniGene 4822
DFCI TC1590519
Consensus CDS Project CCDS25293.1
International Mouse Phenotyping Consortium Status Hoxb8
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000001990 VEGA Gene Model | MGI Sequence Detail 3411 C57BL/6J ±  kb
transcript OTTMUST00000003995 VEGA | MGI Sequence Detail 2635 Not Applicable 
polypeptide OTTMUSP00000001932 VEGA | MGI Sequence Detail 243 Not Applicable 

For the selected sequences
All sequences(29) RefSeq(4) UniProt(3)
Polymorphisms
SNPs within 2kb(13 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000047 Helix-turn-helix motif
InterPro IPR017970 Homeobox, conserved site
InterPro IPR017995 Homeobox protein, antennapedia type
InterPro IPR001827 Homeobox protein, antennapedia type, conserved site
InterPro IPR001356 Homeodomain
InterPro IPR009057 Homeodomain-like
InterPro IPR020479 Homeodomain, metazoa
Protein Ontology PR:000008705 homeobox protein Hox-B8
References
(Earliest) J:8129 Hart CP, et al., Homeo box gene complex on mouse chromosome 11: molecular cloning, expression in embryogenesis, and homology to a human homeo box locus. Cell. 1985 Nov;43(1):9-18
(Latest) J:212315 Gee JM, et al., Imaging Activity in Neurons and Glia with a Polr2a-Based and Cre-Dependent GCaMP5G-IRES-tdTomato Reporter Mouse. Neuron. 2014 Aug 20;
All references(108)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-10832, MGD-MRK-10890

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory