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Hoxb8 Gene Detail
Summary
  • Symbol
    Hoxb8
  • Name
    homeobox B8
  • Synonyms
    Hox-2.4
  • Feature Type
    protein coding gene
  • IDs
    MGI:96189
    NCBI Gene: 15416
  • Member of
    Hoxb cluster
  • Alliance
    genome feature page
  • Transcription Start Sites
    9 TSS
  • Regulated by
    Rr36 (1 regulatory region)
Location &
Maps
more
  • Sequence Map
    Chr11:96172731-96176141 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 59.82 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    66 from dbSNP Build 142
  • Strain Annotations
    19
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96189
 protein coding gene Chr11:96170227-96176151 (+)
129S1/SvImJ ENSMUSG00200051637
 protein coding gene Chr11:93417102-93420512 (+)
A/J ENSMUSG00195047570
 protein coding gene Chr11:93138771-93142179 (+)
AKR/J ENSMUSG00220044825
 protein coding gene Chr11:93397846-93401256 (+)
BALB/cJ ENSMUSG00180046097
 protein coding gene Chr11:93401989-93405401 (+)
C3H/HeJ ENSMUSG00175048984
 protein coding gene Chr11:93397829-93401240 (+)
C57BL/6NJ ENSMUSG00215053824
 protein coding gene Chr11:92990255-92993667 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017025
 protein coding gene Chr11:92053180-92056596 (+)
CAST/EiJ ENSTCUG00005049138
 protein coding gene Chr11:92840975-92844379 (+)
CBA/J ENSMUSG00210051727
 protein coding gene Chr11:93101293-93104701 (+)
DBA/2J ENSMUSG00185049235
 protein coding gene Chr11:93447670-93451080 (+)
FVB/NJ ENSMUSG00205030324
 protein coding gene Chr11:93304160-93307572 (+)
JF1/MsJ ENSUMUG00000017187
 protein coding gene Chr11:93753906-93757315 (+)
LP/J ENSMUSG00230046941
 protein coding gene Chr11:94500184-94503595 (+)
NOD/ShiLtJ ENSMUSG00190045972
 protein coding gene Chr11:93495647-93499057 (+)
NZO/HlLtJ ENSMUSG00225050810
 protein coding gene Chr11:96555968-96559379 (+)
PWK/PhJ ENSLUMG00010050563
 protein coding gene Chr11:93298974-93302376 (+)
SPRET/EiJ ENSMSPG00010046348
 protein coding gene Chr11:93801023-93804448 (+)
WSB/EiJ ENSIUOG00005046437
 protein coding gene Chr11:93243332-93246742 (+)



Homology
more
  • Human Ortholog
    HOXB8, homeobox B8
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HOXB8, homeobox B8
  • Synonyms
    HOX2, Hox-2.4, HOX2D
  • Links
    NCBI Gene ID: 3218
    UniProt: P17481

  • Chr Location
    17q21.32; chr17:48611377-48618003 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Hoxb8 mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    30 phenotypes from 8 alleles in 6 genetic backgrounds
    7 phenotypes from multigenic genotypes
    38 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Most homozygotes for targeted null mutations exhibit delayed preweaning growth, degeneration of the second spinal ganglion, axial skeletal defects, impaired clasping, an altered gait, and excessive grooming.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    51
  • GO References
    18
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1021
  • Tissues
    242
  • cDNA Data
    15
  • Literature Summary
    87
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000056648 Ensembl Gene Model | MGI Sequence Detail 3411 C57BL/6J ±  kb
    transcript ENSMUST00000052650 Ensembl | MGI Sequence Detail 2635 Not Applicable  
    polypeptide ENSMUSP00000052496 Ensembl | MGI Sequence Detail 243 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 50
      Genomic 13
      cDNA 16
      Primer pair 8
      Other 13

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-10832, MGD-MRK-10890
    References
    more
    • Summaries
      All 183
      Developmental Gene Expression 87
      Diseases 1
      Gene Ontology 18
      Phenotypes 38
    • Earliest
      J:8129 Hart CP, et al., Homeo box gene complex on mouse chromosome 11: molecular cloning, expression in embryogenesis, and homology to a human homeo box locus. Cell. 1985 Nov;43(1):9-18
    • Latest
      J:388225 Nagarajan N, et al., Microglia respond to and induce anxiety and grooming in mice using calcium signaling. Mol Psychiatry. 2026 Sep;31(9):4895-4917
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/01/2026
    MGI 6.24     		The Jackson Laboratory