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Hoxb8
Gene Detail
 Symbol
Name
ID
Member of
Hoxb8
homeobox B8
MGI:96189
Hoxb cluster
Synonyms Hox-2.4
Feature Type protein coding gene
Genetic Map
Chromosome 11
59.82 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr11:96281905-96285315 bp, + strand
From VEGA annotation of GRCm38

  3411 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7768  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: homeotic protein Hox A5/D4
Gene Tree: Hoxb8

Human
homologs
Human Homolog HOXB8, homeobox B8
NCBI Gene ID 3218
neXtProt AC  NX_P17481
Human Synonyms  HOX2, Hox-2.4, HOX2D
Human Chr (Location)  17q21.3; chr17:48612346-48615112 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(11) : Targeted(11)
Genomic Mutations involving Hoxb8 (1)
Incidental mutations (data from Mutagenetix , APF )
 
Most homozygotes for targeted null mutations exhibit delayed preweaning growth, degeneration of the second spinal ganglion, axial skeletal defects, impaired clasping, an altered gait, and excessive grooming.
 
Human Diseases Modeled Using Mouse Hoxb8 (1)    Alleles Annotated to Human Diseases(1)   
Interactions
Hoxb8 interacts with 198 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (24 annotations)
Process adult locomotory behavior, anterior/posterior pattern specification, ...
Component nucleus
Function DNA binding, sequence-specific DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (67 records)
Data Summary: Results (254)    Tissues (158)    Images (62)
Theiler Stages: 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28
Assay TypeResults
RNA in situ 225
In situ reporter (knock in) 13
Northern blot 6
RT-PCR 6
RNase protection 4
cDNA source data(12)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(27) Genomic(12) cDNA(13) Primer pair(1) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000001990 (Evidence)
Ensembl Gene ModelENSMUSG00000056648 (Evidence)
Entrez Gene15416 (Evidence)
UniGene4822
DFCITC1590519
Consensus CDS ProjectCCDS25293.1
International Mouse Knockout Project StatusHoxb8
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000001990 VEGA Gene Model | MGI Sequence Detail 3411 C57BL/6J ±  kb
transcript OTTMUST00000003995 VEGA | MGI Sequence Detail 2635 Not Applicable 
polypeptide OTTMUSP00000001932 VEGA | MGI Sequence Detail 243 Not Applicable 

For the selected sequences
All sequences(31) RefSeq(6) UniProt(3)
Polymorphisms SNPs within 2kb(13 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000047 Helix-turn-helix motif
InterPro IPR017970 Homeobox, conserved site
InterPro IPR017995 Homeobox protein, antennapedia type
InterPro IPR001827 Homeobox protein, antennapedia type, conserved site
InterPro IPR001356 Homeodomain
InterPro IPR009057 Homeodomain-like
InterPro IPR020479 Homeodomain, metazoa
Protein Ontology PR:000008705 homeobox protein Hox-B8
References (Earliest) J:8129 Hart CP, et al., Homeo box gene complex on mouse chromosome 11: molecular cloning, expression in embryogenesis, and homology to a human homeo box locus. Cell. 1985 Nov;43(1):9-18
(Latest) J:212315 Gee JM, et al., Imaging Activity in Neurons and Glia with a Polr2a-Based and Cre-Dependent GCaMP5G-IRES-tdTomato Reporter Mouse. Neuron. 2014 Aug 20;
All references(110)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-10832, MGD-MRK-10890

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory