Hoxb8
Gene Detail

Symbol Name ID

Hoxb8 homeobox B8 MGI:96189

Synonyms

Hox-2.4

Feature Type

protein coding gene

Genetic Map

Chromosome 11

59.82 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr11:96281905-96285325 bp, + strand From VEGA annotation of GRCm38   3421 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:7768  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: homeotic protein Hox A5/D4
Gene Tree: Hoxb8

Human homologs

Human Homolog		HOXB8, homeobox B8
NCBI Gene ID		3218
neXtProt AC		NX_P17481
Human Synonyms		HOX2, Hox-2.4, HOX2D
Human Chr (Location)		17q21.3; chr17:46689708-46692301 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(10) : Targeted(10)
 

Most homozygotes for targeted null mutations exhibit delayed preweaning growth, degeneration of the second spinal ganglion, axial skeletal defects, impaired clasping, an altered gait, and excessive grooming.

 
Human Diseases Modeled Using Mouse Hoxb8 (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (26 annotations)

Process	adult locomotory behavior, anterior/posterior pattern specification, ...
Component	nucleus
Function	DNA binding, sequence-specific DNA binding, ...

External Resources: FuncBase

Expression

Literature Summary: (66 records)
Data Summary: Results (229)    Tissues (143)    Images (50)
Theiler Stages: 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
RNA in situ	200
In situ reporter (knock in)	13
Northern blot	6
RT-PCR	6
RNase protection	4

cDNA source data(12)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(27) Genomic(12) cDNA(13) Primer pair(1) Other(1)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000001990 (Evidence)
Ensembl Gene Model	ENSMUSG00000056648 (Evidence)
Entrez Gene	15416 (Evidence)
UniGene	4822
DFCI	TC1590519
Consensus CDS Project	CCDS25293.1
International Mouse Knockout Project Status	Hoxb8

Sequences

Length	Strain/Species
genomic	OTTMUSG00000001990	VEGA Gene Model | MGI Sequence Detail	3421	C57BL/6J
transcript	OTTMUST00000003995	VEGA | MGI Sequence Detail	2645	Not Applicable
polypeptide	OTTMUSP00000001932	VEGA | MGI Sequence Detail	243	Not Applicable

All sequences(27) RefSeq(2) UniProt(3)

Polymorphisms

SNPs(8 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000047	Helix-turn-helix motif
InterPro	IPR017970	Homeobox, conserved site
InterPro	IPR017995	Homeobox protein, antennapedia type
InterPro	IPR001827	Homeobox protein, antennapedia type, conserved site
InterPro	IPR001356	Homeodomain
InterPro	IPR009057	Homeodomain-like
InterPro	IPR020479	Homeodomain, metazoa
Protein Ontology	PR:000008705	homeobox protein Hox-B8

References

(Earliest) J:8129 Hart CP, et al., Homeo box gene complex on mouse chromosome 11: molecular cloning, expression in embryogenesis, and homology to a human homeo box locus. Cell. 1985 Nov;43(1):9-18
(Latest) J:186535 Herriges JC, et al., Genome-scale study of transcription factor expression in the branching mouse lung. Dev Dyn. 2012 Sep;241(9):1432-53
All references(109)

Other accession IDs

MGD-MRK-10832, MGD-MRK-10890