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Hoxb1 Gene Detail
Summary
  • Symbol
    Hoxb1
  • Name
    homeobox B1
  • Synonyms
    Hox-2.9
  • Feature Type
    protein coding gene
  • IDs
    MGI:96182
    NCBI Gene: 15407
  • Member of
    Hoxb cluster
  • Gene Overview
    MyGene.info: HOXB1
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:96365752-96368256 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 59.86 cM
  • Mapping Data
    9 experiments
Strain
Comparison
more
  • SNPs within 2kb
    21 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_96182
protein coding gene Chr11:96365746-96368256 (+)
129S1/SvImJ MGP_129S1SvImJ_G0019009
protein coding gene Chr11:98678849-98681298 (+)
A/J MGP_AJ_G0018977
protein coding gene Chr11:94649874-94652377 (+)
AKR/J MGP_AKRJ_G0018947
protein coding gene Chr11:97577115-97579618 (+)
BALB/cJ MGP_BALBcJ_G0018950
protein coding gene Chr11:95150085-95152537 (+)
C3H/HeJ MGP_C3HHeJ_G0018764
protein coding gene Chr11:97707641-97710100 (+)
C57BL/6NJ MGP_C57BL6NJ_G0019402
protein coding gene Chr11:101762226-101764753 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017032
protein coding gene Chr11:92137177-92139637 (+)
CAST/EiJ MGP_CASTEiJ_G0018317
protein coding gene Chr11:98536703-98539160 (+)
CBA/J MGP_CBAJ_G0018735
protein coding gene Chr11:105924260-105926763 (+)
DBA/2J MGP_DBA2J_G0018843
protein coding gene Chr11:94217397-94219902 (+)
FVB/NJ MGP_FVBNJ_G0018832
protein coding gene Chr11:93696074-93698570 (+)
LP/J MGP_LPJ_G0018913
protein coding gene Chr11:99214537-99217038 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0018859
protein coding gene Chr11:105921399-105924728 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0019442
protein coding gene Chr11:97883608-97886113 (+)
PWK/PhJ MGP_PWKPhJ_G0018089
protein coding gene Chr11:95169929-95172424 (+)
SPRET/EiJ MGP_SPRETEiJ_G0017878
protein coding gene Chr11:97612616-97615064 (+)
WSB/EiJ MGP_WSBEiJ_G0018367
protein coding gene Chr11:97774856-97777331 (+)



Homology
more
  • Human Ortholog
    HOXB1, homeobox B1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    HOXB1, homeobox B1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    HCFP3, HOX2, Hox-2.9, HOX2I
  • Links
    NCBI Gene ID: 3211
    neXtProt AC: NX_P14653
    UniProt: P14653

  • Chr Location
    17q21.32; chr17:48529445-48530910 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 1615
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: HOXB1
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    36 phenotypes from 12 alleles in 9 genetic backgrounds
    56 phenotypes from multigenic genotypes
    53 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a reporter allele die neonatally with altered segmental identity and abnormal migration of motor neurons in the hindbrain. Mice homozygous for null alleles can exhibit partial postnatal lethality, narrow face, runting, absent facial motor nuclei, and facial nerve/muscle defects.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000018973 Ensembl Gene Model | MGI Sequence Detail 2505 C57BL/6J ±  kb
    transcript ENSMUST00000019117 Ensembl | MGI Sequence Detail 2086 Not Applicable  
    polypeptide ENSMUSP00000019117 Ensembl | MGI Sequence Detail 297 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 59
      Genomic 12
      cDNA 36
      Primer pair 10
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-10837, MGD-MRK-10883
    References
    more
    • Summaries
      All 300
      Developmental Gene Expression 210
      Gene Ontology 10
      Phenotypes 53
    • Earliest
      J:32355 Hauser CA, et al., Expression of homologous homeo-box-containing genes in differentiated human teratocarcinoma cells and mouse embryos. Cell. 1985 Nov;43(1):19-28
    • Latest
      J:266434 Hong SH, et al., Corepressor SMRT is required to maintain Hox transcriptional memory during somitogenesis. Proc Natl Acad Sci U S A. 2018 Oct 9;115(41):10381-10386

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    last database update
    11/26/2019
    MGI 6.14
    The Jackson Laboratory