Hoxb1
Gene Detail

Symbol Name ID

Hoxb1 homeobox B1 MGI:96182

Synonyms

Hox-2.9

Feature Type

protein coding gene

Genetic Map

Chromosome 11

59.86 cM
Detailed Genetic Map ± 1 cM


Mapping data(9)

Sequence Map

Chr11:96365752-96368256 bp, + strand From VEGA annotation of GRCm38   2505 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:1615  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Hoxb1

Human homologs

Human Homolog		HOXB1, homeobox B1
NCBI Gene ID		3211
neXtProt AC		NX_P14653
Human Synonyms		HCFP3, HOX2, Hox-2.9, HOX2I
Human Chr (Location)		17q21.3; chr17:46606807-46608272 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human HOXB1

Alleles and phenotypes

All alleles(19) : Targeted(18) Gene trapped(1)
 

Mice homozygous for a reporter allele die neonatally with altered segmental identity and abnormal migration of motor neurons in the hindbrain. Mice homozygous for null alleles can exhibit partial postnatal lethality, narrow face, runting, absent facial motor nuclei, and facial nerve/muscle defects.

 

Gene Ontology (GO) classifications

All GO classifications: (23 annotations)

Process	anatomical structure formation involved in morphogenesis, anatomical structure morphogenesis, ...
Component	cytoplasm, nucleus
Function	DNA binding, protein domain specific binding, ...

External Resources: FuncBase

Expression

Literature Summary: (183 records)
Data Summary: Results (492)    Tissues (198)    Images (200)
Theiler Stages: 2, 3, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
Immunohistochemistry	39
RNA in situ	355
In situ reporter (knock in)	16
Northern blot	15
RT-PCR	63
RNase protection	4

cDNA source data(25)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(53) Genomic(12) cDNA(32) Primer pair(8) Other(1)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000001776 (Evidence)
Ensembl Gene Model	ENSMUSG00000018973 (Evidence)
Entrez Gene	15407 (Evidence)
NIA Mouse Gene Index	U013253, U287746
Consensus CDS Project	CCDS25300.1
International Mouse Knockout Project Status	Hoxb1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000001776	VEGA Gene Model | MGI Sequence Detail	2505	C57BL/6J
transcript	OTTMUST00000003560	VEGA | MGI Sequence Detail	2086	Not Applicable
polypeptide	OTTMUSP00000001715	VEGA | MGI Sequence Detail	297	Not Applicable

All sequences(27) RefSeq(2) UniProt(2)

Polymorphisms

All PCR and RFLP(3) : PCR(2) RFLP(1) SNPs(8 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR017970	Homeobox, conserved site
InterPro	IPR001356	Homeodomain
InterPro	IPR009057	Homeodomain-like
InterPro	IPR020479	Homeodomain, metazoa
Protein Ontology	PR:000008697	homeobox protein Hox-B1

References

(Earliest) J:32355 Hauser CA, et al., Expression of homologous homeo-box-containing genes in differentiated human teratocarcinoma cells and mouse embryos. Cell. 1985 Nov;43(1):19-28
(Latest) J:190545 Boulet AM, et al., Signaling by FGF4 and FGF8 is required for axial elongation of the mouse embryo. Dev Biol. 2012 Nov 15;371(2):235-45
All references(254)

Other accession IDs

MGD-MRK-10837, MGD-MRK-10883