About   Help   FAQ
Hoxb1
Gene Detail
Symbol

Name
ID
Member of
Hoxb1
homeobox B1
MGI:96182
Hoxb cluster
Synonyms
Hox-2.9
Feature Type
protein coding gene
Genetic Map
Chromosome 11
59.86 cM
Detailed Genetic Map ± 1 cM


Mapping data(9)
Sequence Map
Chr11:96365752-96368256 bp, + strand
From VEGA annotation of GRCm38

  2505 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1615  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: HOXB1
Gene Tree: Hoxb1

Human
homologs
HOXB1, homeobox B1
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 3211
neXtProt AC: NX_P14653

Human Synonyms: HCFP3, HOX2, Hox-2.9, HOX2I

Human Chr (Location): 17q21.3; chr17:48529445-48530910 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human HOXB1

Mutations,
alleles, and
phenotypes
All mutations/alleles(22) : Gene trapped(1) Targeted(21)
Genomic Mutations involving Hoxb1 (3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a reporter allele die neonatally with altered segmental identity and abnormal migration of motor neurons in the hindbrain. Mice homozygous for null alleles can exhibit partial postnatal lethality, narrow face, runting, absent facial motor nuclei, and facial nerve/muscle defects.
 
Interactions
Hoxb1 interacts with 180 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (21 annotations)
Process anatomical structure formation involved in morphogenesis, anatomical structure morphogenesis, ...
Component nucleus
Function DNA binding, protein domain specific binding, ...
External Resources: FuncBase
Expression
Literature Summary: (193 records)
Data Summary: Results (517)    Tissues (202)    Images (216)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 39
RNA in situ 378
In situ reporter (knock in) 16
Northern blot 15
RT-PCR 65
RNase protection 4
cDNA source data(25)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA HOXB1 ZFIN hoxb1a, hoxb1b    NEW 
Molecular
reagents
All nucleic(53) Genomic(12) cDNA(32) Primer pair(8) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000001776 (Evidence)
Ensembl Gene Model ENSMUSG00000018973 (Evidence)
Entrez Gene 15407 (Evidence)
NIA Mouse Gene Index U013253, U287746
Consensus CDS Project CCDS25300.1
International Mouse Phenotyping Consortium Status Hoxb1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000001776 VEGA Gene Model | MGI Sequence Detail 2505 C57BL/6J ±  kb
transcript OTTMUST00000003560 VEGA | MGI Sequence Detail 2086 Not Applicable 
polypeptide OTTMUSP00000001715 VEGA | MGI Sequence Detail 297 Not Applicable 

For the selected sequences
All sequences(29) RefSeq(4) UniProt(2)
Polymorphisms
All PCR and RFLP(3) : PCR(2) RFLP(1) SNPs within 2kb(21 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017970 Homeobox, conserved site
InterPro IPR001356 Homeodomain
InterPro IPR009057 Homeodomain-like
InterPro IPR020479 Homeodomain, metazoa
Protein Ontology PR:000008697 homeobox protein Hox-B1
References
(Earliest) J:32355 Hauser CA, et al., Expression of homologous homeo-box-containing genes in differentiated human teratocarcinoma cells and mouse embryos. Cell. 1985 Nov;43(1):19-28
(Latest) J:213512 Werber M, et al., The tissue-specific transcriptomic landscape of the mid-gestational mouse embryo. Development. 2014 Jun;141(11):2325-30
All references(263)
Other
accession IDs
MGD-MRK-10837, MGD-MRK-10883

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
07/21/2015
MGI 5.22
The Jackson Laboratory