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Gusb
Gene Detail
Symbol

Name
ID
Gusb
glucuronidase, beta
MGI:95872
Synonyms
adipose storage deficiency, asd, g, Gur, Gus, Gus-r, Gus-s, Gus-t, Gus-u, Gut
Feature Type
protein coding gene
Genetic Map
Chromosome 5
68.32 cM
Detailed Genetic Map ± 1 cM


Mapping data(109)
Sequence Map
Chr5:129989011-130003049 bp, - strand
From VEGA annotation of GRCm38

  14039 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:37271  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

HCOP human homology predictions: GUSB
Protein SuperFamily: beta-glucuronidase
Gene Tree: Gusb

Human
homologs
GUSB, glucuronidase, beta
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 2990
neXtProt AC: NX_P08236

Human Synonyms: BG, MPS7

Human Chr (Location): 7q21.11; chr7:65960684-65982314 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human GUSB

Mutations,
alleles, and
phenotypes
All mutations/alleles(12) : Chemically induced (ENU)(1) Gene trapped(2) Spontaneous(2) Targeted(6) Transgenic(1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Knock-in mutations of this gene lead to lysosomal storage disease and may cause premature death, facial, tail and limb anomalies, growth retardation, male sterility, reduced lactation, osteosclerosis and behavioral defects. Additional phenotypes include partial neonatal death and deafness.
 
Human Diseases Modeled in Mice Using Gusb (1)    Mutations Annotated to Human Diseases (7)    Phenotype Images(1)
Interactions
Gusb interacts with 163 markers (Mir7-1, Mir17, Mir18, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (19 annotations)
Process carbohydrate metabolic process, glucuronoside catabolic process, ...
Component endoplasmic reticulum, extracellular exosome, ...
Function beta-glucuronidase activity, carbohydrate binding, ...
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (117)    Tissues (97)    Images (29)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 117
cDNA source data(122)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase gusb    NEW 
Molecular
reagents
All nucleic(146) Genomic(21) cDNA(122) Primer pair(2) Other(1)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000024068 (Evidence)
Ensembl Gene Model ENSMUSG00000025534 (Evidence)
Entrez Gene 110006 (Evidence)
UniGene 3317
DFCI TC1578349, TC1584817, TC1587378, TC1597739, TC1600624, TC1600970
DoTS DT.101386470, DT.101386471, DT.101735968, DT.101735969, DT.110652911, DT.534977
NIA Mouse Gene Index U026768
EC 3.2.1.31
Consensus CDS Project CCDS19705.1
International Mouse Phenotyping Consortium Status Gusb
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000024068 VEGA Gene Model | MGI Sequence Detail 14039 C57BL/6J ±  kb
transcript OTTMUST00000058837 VEGA | MGI Sequence Detail 2687 Not Applicable 
polypeptide OTTMUSP00000028562 VEGA | MGI Sequence Detail 648 Not Applicable 

For the selected sequences
All sequences(84) RefSeq(7) UniProt(6)
Polymorphisms
All PCR and RFLP(21) : PCR(4) RFLP(17) SNPs within 2kb(138 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008979 Galactose-binding domain-like
InterPro IPR013781 Glycoside hydrolase, catalytic domain
InterPro IPR006101 Glycoside hydrolase, family 2
InterPro IPR013812 Glycoside hydrolase, family 2/20, immunoglobulin-like beta-sandwich domain
InterPro IPR023232 Glycoside hydrolase, family 2, active site
InterPro IPR006103 Glycoside hydrolase family 2, catalytic domain
InterPro IPR023230 Glycoside hydrolase, family 2, conserved site
InterPro IPR006102 Glycoside hydrolase, family 2, immunoglobulin-like beta-sandwich
InterPro IPR017853 Glycoside hydrolase superfamily
InterPro IPR006104 Glycosyl hydrolases family 2, sugar binding domain
Protein Ontology PR:000008358 beta-glucuronidase
References
(Earliest) J:286 PAIGEN K, The genetic control of enzyme activity during differentiation. Proc Natl Acad Sci U S A. 1961 Oct 15;47:1641-9
(Latest) J:220353 Xing EM, et al., The effect of Tlr4 and/or C3 deficiency and of neonatal gene therapy on skeletal disease in mucopolysaccharidosis VII mice. Mol Genet Metab. 2015 Feb;114(2):209-16
All references(215)
Disease annotation references (10)
Other
accession IDs
MGD-MRK-10333, MGD-MRK-10334, MGD-MRK-10335, MGD-MRK-10336, MGD-MRK-10337, MGD-MRK-1413, MGD-MRK-19421, MGD-MRK-19422, MGD-MRK-9912, MGI:2140959, MGI:95873, MGI:95874, MGI:95875, MGI:95876

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory