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Grin2a
Gene Detail
Symbol

Name
ID
Grin2a
glutamate receptor, ionotropic, NMDA2A (epsilon 1)
MGI:95820
Synonyms
GluN2A, GluRepsilon1, NMDAR2A, NR2A
Feature Type
protein coding gene
Genetic Map
Chromosome 16
5.28 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr16:9577710-9994921 bp, - strand
From VEGA annotation of GRCm38

  417212 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:645  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: GRIN2A
Protein SuperFamily: N-methyl-D-aspartate receptor 2A
Gene Tree: Grin2a

Human
homologs
GRIN2A, glutamate receptor, ionotropic, N-methyl D-aspartate 2A
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 2903
neXtProt AC: NX_Q12879

Human Synonyms: EPND, FESD, GluN2A, LKS, NMDAR2A, NR2A

Human Chr (Location): 16p13.2; chr16:9753404-10183364 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Targeted(8)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygotes for targeted null mutations exhibit jumpiness, mildly impaired long-term potentiation and spatial learning, increased locomotor activity and metabolism of dopamine and serotonin, and loss of analgesic tolerance after repeated morphine doses.
 
Interactions
Grin2a interacts with 53 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (129 annotations)
Process action potential, calcium ion transmembrane transport, ...
Component cell junction, cell surface, ...
Function ATPase binding, calcium channel activity, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (23 records)
Data Summary: Results (246)    Tissues (89)    Images (32)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 145
Western blot 1
RT-PCR 100
cDNA source data(8)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA GRIN2A ZFIN grin2aa    NEW 
Molecular
reagents
All nucleic(22) Genomic(2) cDNA(10) Primer pair(2) Other(8)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000016264 (Evidence)
Ensembl Gene Model ENSMUSG00000059003 (Evidence)
Entrez Gene 14811 (Evidence)
UniGene 2953
DFCI TC1715036
DoTS DT.91331803, DT.91588547
NIA Mouse Gene Index U036775, U090515
Consensus CDS Project CCDS27943.1
International Mouse Phenotyping Consortium Status Grin2a
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016264 VEGA Gene Model | MGI Sequence Detail 417212 C57BL/6J ±  kb
transcript OTTMUST00000038999 VEGA | MGI Sequence Detail 4820 Not Applicable 
polypeptide OTTMUSP00000017426 VEGA | MGI Sequence Detail 1464 Not Applicable 

For the selected sequences
All sequences(27) RefSeq(6) UniProt(1)
Polymorphisms
RFLP(1) : SNPs within 2kb(2339 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001828 Extracellular ligand-binding receptor
InterPro IPR018884 Glutamate [NMDA] receptor, epsilon subunit, C-terminal
InterPro IPR019594 Glutamate receptor, L-glutamate/glycine-binding
InterPro IPR001320 Ionotropic glutamate receptor
InterPro IPR001508 NMDA receptor
Protein Ontology PR:000008246 glutamate receptor ionotropic, NMDA 2A
References
(Earliest) J:1333 Kutsuwada T, et al., Molecular diversity of the NMDA receptor channel [see comments]. Nature. 1992 Jul 2;358(6381):36-41
(Latest) J:207152 Tomiyama K, et al., Phenotypic characterization of orofacial movement topography in mutants with disruption of amino acid mechanisms: glutamate N2A/B/D [GluRepsilon1/2/4] subtypes and the GABA synthesizing enzyme GAD65. Neuroscience. 2013 Oct 10;250:743-54
All references(172)
Other
accession IDs
MGD-MRK-10258

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/20/2015
MGI 5.22
The Jackson Laboratory