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Grin2a
Gene Detail
 Symbol
Name
ID
Grin2a
glutamate receptor, ionotropic, NMDA2A (epsilon 1)
MGI:95820
Synonyms GluN2A, GluRepsilon1, NMDAR2A, NR2A
Feature Type protein coding gene
Genetic Map
Chromosome 16
5.28 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr16:9577710-9994921 bp, - strand
From VEGA annotation of GRCm38

  417212 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:645  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: N-methyl-D-aspartate receptor 2A
Gene Tree: Grin2a

Human
homologs
Human Homolog GRIN2A, glutamate receptor, ionotropic, N-methyl D-aspartate 2A
NCBI Gene ID 2903
neXtProt AC  NX_Q12879
Human Synonyms  EPND, FESD, GluN2A, LKS, NMDAR2A, NR2A
Human Chr (Location)  16p13.2; chr16:9753408-10182754 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human GRIN2A
Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Targeted(8)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for targeted null mutations exhibit jumpiness, mildly impaired long-term potentiation and spatial learning, increased locomotor activity and metabolism of dopamine and serotonin, and loss of analgesic tolerance after repeated morphine doses.
 
Interactions
Grin2a interacts with 53 markers (Mir9-1, Mir9-2, Mir9-3, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (128 annotations)
Process action potential, calcium ion transmembrane transport, ...
Component cell junction, cell surface, ...
Function ATPase binding, calcium channel activity, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (23 records)
Data Summary: Results (246)    Tissues (88)    Images (32)
Theiler Stages: 19, 23, 26, 28
Assay TypeResults
RNA in situ 145
Western blot 1
RT-PCR 100
cDNA source data(8)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(22) Genomic(2) cDNA(10) Primer pair(2) Other(8)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000016264 (Evidence)
Ensembl Gene ModelENSMUSG00000059003 (Evidence)
Entrez Gene14811 (Evidence)
UniGene2953
DFCITC1715036
DoTSDT.91331803, DT.91588547
NIA Mouse Gene IndexU036775, U090515
Consensus CDS ProjectCCDS27943.1
International Mouse Knockout Project StatusGrin2a
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016264 VEGA Gene Model | MGI Sequence Detail 417212 C57BL/6J ±  kb
transcript OTTMUST00000038999 VEGA | MGI Sequence Detail 4820 Not Applicable 
polypeptide OTTMUSP00000017426 VEGA | MGI Sequence Detail 1464 Not Applicable 

For the selected sequences
All sequences(27) RefSeq(6) UniProt(1)
Polymorphisms RFLP(1) : SNPs within 2kb(2339 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001828 Extracellular ligand-binding receptor
InterPro IPR001638 Extracellular solute-binding protein, family 3
InterPro IPR018884 Glutamate [NMDA] receptor, epsilon subunit, C-terminal
InterPro IPR019594 Glutamate receptor, L-glutamate/glycine-binding
InterPro IPR001320 Ionotropic glutamate receptor
InterPro IPR001508 NMDA receptor
Protein Ontology PR:000008246 glutamate receptor ionotropic, NMDA 2A
References (Earliest) J:1333 Kutsuwada T, et al., Molecular diversity of the NMDA receptor channel [see comments]. Nature. 1992 Jul 2;358(6381):36-41
(Latest) J:207152 Tomiyama K, et al., Phenotypic characterization of orofacial movement topography in mutants with disruption of amino acid mechanisms: glutamate N2A/B/D [GluRepsilon1/2/4] subtypes and the GABA synthesizing enzyme GAD65. Neuroscience. 2013 Oct 10;250:743-54
All references(175)
Other
accession IDs
MGD-MRK-10258

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory