Grin2a
Gene Detail

Symbol Name ID

Grin2a glutamate receptor, ionotropic, NMDA2A (epsilon 1) MGI:95820

Synonyms

GluN2A, GluRepsilon1, NMDAR2A, NR2A

Feature Type

protein coding gene

Genetic Map

Chromosome 16

5.28 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr16:9577710-9994921 bp, - strand From VEGA annotation of GRCm38   417212 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:645  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: N-methyl-D-aspartate receptor 2A
Gene Tree: Grin2a

Human homologs

Human Homolog		GRIN2A, glutamate receptor, ionotropic, N-methyl D-aspartate 2A
NCBI Gene ID		2903
neXtProt AC		NX_Q12879
Human Synonyms		EPND, GluN2A, NMDAR2A, NR2A
Human Chr (Location)		16p13.2; chr16:9847265-10276611 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human GRIN2A

Alleles and phenotypes

All alleles(7) : Targeted(7)
 

Homozygotes for targeted null mutations exhibit jumpiness, mildly impaired long-term potentiation and spatial learning, increased locomotor activity and metabolism of dopamine and serotonin, and loss of analgesic tolerance after repeated morphine doses.

 

Gene Ontology (GO) classifications

All GO classifications: (124 annotations)

Process	calcium ion transmembrane transport, calcium ion transport, ...
Component	cell junction, cell surface, ...
Function	ATPase binding, calcium channel activity, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (22 records)
Data Summary: Results (246)    Tissues (88)    Images (32)
Theiler Stages: 19, 23, 26, 28

Assay Type	Results
RNA in situ	145
Western blot	1
RT-PCR	100

cDNA source data(7)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(21) Genomic(2) cDNA(9) Primer pair(2) Other(8)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000016264 (Evidence)
Ensembl Gene Model	ENSMUSG00000059003 (Evidence)
Entrez Gene	14811 (Evidence)
UniGene	2953
DFCI	TC1715036
DoTS	DT.91331803
NIA Mouse Gene Index	U036775
Consensus CDS Project	CCDS27943.1
International Mouse Knockout Project Status	Grin2a

Sequences

Length	Strain/Species
genomic	OTTMUSG00000016264	VEGA Gene Model | MGI Sequence Detail	417212	C57BL/6J
transcript	OTTMUST00000038999	VEGA | MGI Sequence Detail	4820	Not Applicable
polypeptide	OTTMUSP00000017426	VEGA | MGI Sequence Detail	1464	Not Applicable

All sequences(20) RefSeq(2) UniProt(1)

Polymorphisms

RFLP(1) : SNPs(2024 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001828	Extracellular ligand-binding receptor
InterPro	IPR001638	Extracellular solute-binding protein, family 3
InterPro	IPR018884	Glutamate [NMDA] receptor, epsilon subunit, C-terminal
InterPro	IPR019594	Glutamate receptor, L-glutamate/glycine-binding
InterPro	IPR001320	Ionotropic glutamate receptor
InterPro	IPR001508	NMDA receptor
Protein Ontology	PR:000008246	glutamate [NMDA] receptor subunit epsilon-1

References

(Earliest) J:1333 Kutsuwada T, et al., Molecular diversity of the NMDA receptor channel [see comments]. Nature. 1992 Jul 2;358(6381):36-41
(Latest) J:189050 Wang L, et al., Female mouse fetal loss mediated by maternal autoantibody. J Exp Med. 2012 Jun 4;209(6):1083-9
All references(167)

Other accession IDs

MGD-MRK-10258