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Grik5
Gene Detail
 Symbol
Name
ID
Grik5
glutamate receptor, ionotropic, kainate 5 (gamma 2)
MGI:95818
Synonyms GluRgamma2, KA2
Feature Type protein coding gene
Genetic Map
Chromosome 7
13.73 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr7:25009853-25072369 bp, - strand
From Ensembl annotation of GRCm38

  62517 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1578  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 zebrafish

Protein SuperFamily: ionotropic glutamate receptor, AMPA/kainate types
Gene Tree: Grik5

Human
homologs
Human Homolog GRIK5, glutamate receptor, ionotropic, kainate 5
NCBI Gene ID 2901
neXtProt AC  NX_Q16478
Human Synonyms  EAA2, GluK5, GRIK2, KA2
Human Chr (Location)  19q13.2; chr19:41998316-42070210 (-)  GRCh38
Alleles
and
phenotypes
All alleles(3) : Targeted(3)
 
Mice homozygous for one allele display abnormal hippocampal synapse function. Mice homozygous for a second allele display decreased thermal nociception, increased startle response and increased susceptibility to pharmacologically induced seizures.
 
Gene Ontology
(GO)
classifications
All GO classifications: (48 annotations)
Process establishment of localization in cell, ionotropic glutamate receptor signaling pathway, ...
Component axon, cell junction, ...
Function extracellular-glutamate-gated ion channel activity, glutamate receptor activity, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (321)    Tissues (125)    Images (130)
Theiler Stages: 22, 23, 28
Assay TypeResults
RNA in situ 141
In situ reporter (knock in) 142
RT-PCR 38
cDNA source data(65)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(67) cDNA(66) Primer pair(1)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000003378 (Evidence)
Entrez Gene14809 (Evidence)
UniGene2879
DFCITC1579622, TC1603526, TC1651374
DoTSDT.101724424, DT.110989028, DT.40158354, DT.55120046
NIA Mouse Gene IndexU028265
Consensus CDS ProjectCCDS20970.1
International Mouse Knockout Project StatusGrik5
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000003378 Ensembl Gene Model | MGI Sequence Detail 62517 C57BL/6J ±  kb
transcript ENSMUST00000003468 Ensembl | MGI Sequence Detail 3836 Not Applicable 
polypeptide ENSMUSP00000003468 Ensembl | MGI Sequence Detail 979 Not Applicable 

For the selected sequences
All sequences(38) RefSeq(14) UniProt(4)
Polymorphisms RFLP(1) : SNPs within 2kb(292 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001828 Extracellular ligand-binding receptor
InterPro IPR019594 Glutamate receptor, L-glutamate/glycine-binding
InterPro IPR001320 Ionotropic glutamate receptor
InterPro IPR001508 NMDA receptor
Protein Ontology PR:000008244 glutamate receptor, ionotropic kainate 5
References (Earliest) J:696 Sakimura K, et al., Primary structure and expression of the gamma 2 subunit of the glutamate receptor channel selective for kainate. Neuron. 1992 Feb;8(2):267-74
(Latest) J:201543 Yan D, et al., Homeostatic control of synaptic transmission by distinct glutamate receptors. Neuron. 2013 May 22;78(4):687-99
All references(50)
Other
accession IDs
MGD-MRK-10256

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory