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Grik5
Gene Detail
Symbol

Name
ID
Grik5
glutamate receptor, ionotropic, kainate 5 (gamma 2)
MGI:95818
Synonyms
GluRgamma2, KA2
Feature Type
protein coding gene
Genetic Map
Chromosome 7
13.73 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr7:25009853-25072369 bp, - strand
From Ensembl annotation of GRCm38

  62517 bp   ±  kb flank

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Mouse Genome Browser
Vertebrate
homology
HomoloGene:1578  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: ionotropic glutamate receptor, AMPA/kainate types
Gene Tree: Grik5

Human
homologs
Human Homolog GRIK5, glutamate receptor, ionotropic, kainate 5
NCBI Gene ID 2901
neXtProt AC  NX_Q16478
Human Synonyms  EAA2, GluK5, GRIK2, KA2
Human Chr (Location)  19q13.2; chr19:41998316-42070210 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for one allele display abnormal hippocampal synapse function. Mice homozygous for a second allele display decreased thermal nociception, increased startle response and increased susceptibility to pharmacologically induced seizures.
 
Interactions
Grik5 interacts with 88 markers (Mir19b-1, Mir19b-2, Mir22, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (7 records)
Data Summary: Results (321)    Tissues (125)    Images (130)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 141
In situ reporter (knock in) 142
RT-PCR 38
cDNA source data(65)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(67) cDNA(66) Primer pair(1)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000003378 (Evidence)
Entrez Gene14809 (Evidence)
UniGene2879
DFCITC1579622, TC1603526, TC1651374
DoTSDT.101724424, DT.110989028, DT.40158354, DT.55120046
NIA Mouse Gene IndexU028265
Consensus CDS ProjectCCDS20970.1
International Mouse Knockout Project StatusGrik5
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000003378 Ensembl Gene Model | MGI Sequence Detail 62517 C57BL/6J ±  kb
transcript ENSMUST00000003468 Ensembl | MGI Sequence Detail 3836 Not Applicable 
polypeptide ENSMUSP00000003468 Ensembl | MGI Sequence Detail 979 Not Applicable 

For the selected sequences
All sequences(41) RefSeq(14) UniProt(7)
Polymorphisms
RFLP(1) : SNPs within 2kb(292 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001828 Extracellular ligand-binding receptor
InterPro IPR019594 Glutamate receptor, L-glutamate/glycine-binding
InterPro IPR001320 Ionotropic glutamate receptor
InterPro IPR001508 NMDA receptor
Protein Ontology PR:000008244 glutamate receptor ionotropic, kainate 5
References
(Earliest) J:696 Sakimura K, et al., Primary structure and expression of the gamma 2 subunit of the glutamate receptor channel selective for kainate. Neuron. 1992 Feb;8(2):267-74
(Latest) J:204166 Marques JM, et al., CRMP2 tethers kainate receptor activity to cytoskeleton dynamics during neuronal maturation. J Neurosci. 2013 Nov 13;33(46):18298-310
All references(51)
Other
accession IDs
MGD-MRK-10256

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/11/2014
MGI 5.20
The Jackson Laboratory