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Grik5 Gene Detail
Summary
  • Symbol
    Grik5
  • Name
    glutamate receptor, ionotropic, kainate 5 (gamma 2)
  • Synonyms
    GluRgamma2, KA2
  • Feature Type
    protein coding gene
  • IDs
    MGI:95818
    NCBI Gene: 14809
  • Gene Overview
    MyGene.info: GRIK5
  • Alliance
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:25009849-25072346 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 13.73 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    288 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95818
protein coding gene Chr7:25009849-25072369 (-)
129S1/SvImJ MGP_129S1SvImJ_G0031852
protein coding gene Chr7:23430786-23497380 (-)
A/J MGP_AJ_G0031831
protein coding gene Chr7:22848656-22911836 (-)
AKR/J MGP_AKRJ_G0031760
protein coding gene Chr7:23382561-23445574 (-)
BALB/cJ MGP_BALBcJ_G0031838
protein coding gene Chr7:23051925-23115891 (-)
C3H/HeJ MGP_C3HHeJ_G0031557
protein coding gene Chr7:23805385-23872036 (-)
C57BL/6NJ MGP_C57BL6NJ_G0032300
protein coding gene Chr7:24215613-24283152 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029355
protein coding gene Chr7:24277474-24339115 (-)
CAST/EiJ MGP_CASTEiJ_G0030897
protein coding gene Chr7:17280566-17344859 (-)
CBA/J MGP_CBAJ_G0031522
protein coding gene Chr7:25099917-25173633 (-)
DBA/2J MGP_DBA2J_G0031676
protein coding gene Chr7:22752521-22816110 (-)
FVB/NJ MGP_FVBNJ_G0031629
protein coding gene Chr7:22740762-22805229 (-)
LP/J MGP_LPJ_G0031755
protein coding gene Chr7:23740818-23810753 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0031666
protein coding gene Chr7:24834703-24906428 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0032332
protein coding gene Chr7:23078605-23146553 (-)
PWK/PhJ MGP_PWKPhJ_G0030621
protein coding gene Chr7:17682893-17745799 (-)
SPRET/EiJ MGP_SPRETEiJ_G0030452
protein coding gene Chr7:14395434-14460649 (-)
WSB/EiJ MGP_WSBEiJ_G0031000
protein coding gene Chr7:23249416-23317420 (-)



Homology
more
  • Human Ortholog
    GRIK5, glutamate ionotropic receptor kainate type subunit 5
  • Vertebrate Orthologs
    8
  • Human Ortholog
    GRIK5, glutamate ionotropic receptor kainate type subunit 5
    Orthology source: HGNC, HomoloGene
  • Synonyms
    EAA2, GluK5, GRIK2, KA2
  • Links
    NCBI Gene ID: 2901
    neXtProt AC: NX_Q16478
    UniProt: Q16478

  • Chr Location
    19q13.2; chr19:41998316-42071804 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotypes from 2 alleles in 2 genetic backgrounds
    3 phenotypes from multigenic genotypes
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for one allele display abnormal hippocampal synapse function. Mice homozygous for a second allele display decreased thermal nociception, increased startle response and increased susceptibility to pharmacologically induced seizures.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000003378 Ensembl Gene Model | MGI Sequence Detail 62498 C57BL/6J ±  kb
    transcript ENSMUST00000003468 Ensembl | MGI Sequence Detail 3763 Not Applicable  
    polypeptide ENSMUSP00000003468 Ensembl | MGI Sequence Detail 979 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      6 Sequences
    • Protein Ontology
      PR:000008244 glutamate receptor ionotropic, kainate 5
    • InterPro Domains
      IPR001320 Ionotropic glutamate receptor
      IPR019594 Ionotropic glutamate receptor, L-glutamate and glycine-binding domain
      IPR001508 Ionotropic glutamate receptor, metazoa
      IPR028082 Periplasmic binding protein-like I
      IPR001828 Receptor, ligand binding region
    Molecular
    Reagents
    less
    • All nucleic 69
      cDNA 68
      Primer pair 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-10256
    References
    more
    • Summaries
      All 55
      Developmental Gene Expression 8
      Gene Ontology 14
      Phenotypes 14
    • Earliest
      J:696 Sakimura K, et al., Primary structure and expression of the gamma 2 subunit of the glutamate receptor channel selective for kainate. Neuron. 1992 Feb;8(2):267-74
    • Latest
      J:246743 Haumann I, et al., Presynaptic localization of GluK5 in rod photoreceptors suggests a novel function of high affinity glutamate receptors in the mammalian retina. PLoS One. 2017;12(2):e0172967

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    Funding Information
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    last database update
    12/04/2018
    MGI 6.13
    The Jackson Laboratory