Grik5
Gene Detail

Symbol Name ID

Grik5 glutamate receptor, ionotropic, kainate 5 (gamma 2) MGI:95818

Synonyms

GluRgamma2, KA2

Feature Type

protein coding gene

Genetic Map

Chromosome 7

13.73 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)

Sequence Map

Chr7:25009853-25072369 bp, - strand From Ensembl annotation of GRCm38   62517 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Mammalian homology

human; rat; chimpanzee; dog, domestic    (Mammalian Orthology)
Comparative Map (Mouse/Human Grik5 ± 2 cM)

Protein SuperFamily: ionotropic glutamate receptor, AMPA/kainate types
Gene Tree: Grik5

Human ortholog

GRIK5 glutamate receptor, ionotropic, kainate 5 NCBI Gene ID 2901
Human Synonyms: EAA2, GluK5, GRIK2, KA2
Human Chr19:42502473-42569957 bp, - strand Reference GRCh37.p2 Primary Assembly

Alleles and phenotypes

All alleles(3) : Targeted(3)
 

Mice homozygous for one allele display abnormal hippocampal synapse function. Mice homozygous for a second allele display decreased thermal nociception, increased startle response and increased susceptibility to pharmacologically induced seizures.

 

Gene Ontology (GO) classifications

All GO classifications: (46 annotations)

Process	establishment of localization in cell, ionotropic glutamate receptor signaling pathway, ...
Component	axon, cell junction, ...
Function	extracellular-glutamate-gated ion channel activity, glutamate receptor activity, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (6 records)
Data Summary: Results (321)    Tissues (125)    Images (130)
Theiler Stages: 22, 23, 28

Assay Type	Results
RNA in situ	141
In situ reporter (knock in)	142
RT-PCR	38

cDNA source data(65)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(67) cDNA(66) Primer pair(1)
Microarray probesets(4)

Other database links

Ensembl Gene Model	ENSMUSG00000003378 (Evidence)
Entrez Gene	14809 (Evidence)
UniGene	2879
DFCI	TC1579622, TC1603526, TC1651374
DoTS	DT.101724424, DT.110989028, DT.40158354, DT.55120046
NIA Mouse Gene Index	U028265
Consensus CDS Project	CCDS20970.1
International Mouse Knockout Project Status	Grik5

Sequences

Length	Strain/Species
genomic	ENSMUSG00000003378	Ensembl Gene Model | MGI Sequence Detail	62517	C57BL/6J
transcript	ENSMUST00000003468	Ensembl | MGI Sequence Detail	3836	Not Applicable
polypeptide	ENSMUSP00000003468	Ensembl | MGI Sequence Detail	979	Not Applicable

All sequences(26) RefSeq(2) UniProt(4)

Polymorphisms

RFLP(1) : SNPs(252 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001828	Extracellular ligand-binding receptor
InterPro	IPR019594	Glutamate receptor, L-glutamate/glycine-binding
InterPro	IPR001320	Ionotropic glutamate receptor
InterPro	IPR001508	NMDA receptor
Protein Ontology	PR:000008244	glutamate receptor, ionotropic kainate 5

References

(Earliest) J:696 Sakimura K, et al., Primary structure and expression of the gamma 2 subunit of the glutamate receptor channel selective for kainate. Neuron. 1992 Feb;8(2):267-74
(Latest) J:185665 Guo Z, et al., Tlx1/3 and ptf1a control the expression of distinct sets of transmitter and Peptide receptor genes in the developing dorsal spinal cord. J Neurosci. 2012 Jun 20;32(25):8509-20
All references(46)

Other accession IDs

MGD-MRK-10256