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Gria1 Gene Detail
Summary
  • Symbol
    Gria1
  • Name
    glutamate receptor, ionotropic, AMPA1 (alpha 1)
  • Synonyms
    2900051M01Rik, Glr-1, Glr1, GluA1, Glur-1, Glur1, GluR1, GluR-A, GluRA, HIPA1
  • Feature Type
    protein coding gene
  • IDs
    MGI:95808
    NCBI Gene: 14799
  • Alliance
    gene page
  • Transcription Start Sites
    9 TSS
  • Candidate for QTL
    1 QTL
Location &
Maps
more
  • Sequence Map
    Chr11:56902342-57221070 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 34.51 cM
  • Mapping Data
    11 experiments
Strain
Comparison
more
  • SNPs within 2kb
    20332 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95808
 protein coding gene Chr11:56902213-57221070 (+)
129S1/SvImJ MGP_129S1SvImJ_G0018335
 protein coding gene Chr11:56600237-56934078 (+)
A/J MGP_AJ_G0018304
 protein coding gene Chr11:54480133-54804874 (+)
AKR/J MGP_AKRJ_G0018273
 protein coding gene Chr11:56275670-56604138 (+)
BALB/cJ MGP_BALBcJ_G0018275
 protein coding gene Chr11:54823098-55145078 (+)
C3H/HeJ MGP_C3HHeJ_G0018087
 protein coding gene Chr11:56208253-56533893 (+)
C57BL/6NJ MGP_C57BL6NJ_G0018727
 protein coding gene Chr11:58321471-58673305 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0016377
 protein coding gene Chr11:51860638-52182339 (+)
CAST/EiJ MGP_CASTEiJ_G0017651
 protein coding gene Chr11:56248438-56579756 (+)
CBA/J MGP_CBAJ_G0018061
 protein coding gene Chr11:61047242-61394002 (+)
DBA/2J MGP_DBA2J_G0018170
 protein coding gene Chr11:54135734-54459911 (+)
FVB/NJ MGP_FVBNJ_G0018162
 protein coding gene Chr11:53819644-54139445 (+)
LP/J MGP_LPJ_G0018245
 protein coding gene Chr11:57088233-57429872 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0018188
 protein coding gene Chr11:62211997-62547823 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0018769
 protein coding gene Chr11:56289294-56611542 (+)
PWK/PhJ MGP_PWKPhJ_G0017424
 protein coding gene Chr11:54731182-55051492 (+)
SPRET/EiJ MGP_SPRETEiJ_G0017219
 protein coding gene Chr11:56173401-56494207 (+)
WSB/EiJ MGP_WSBEiJ_G0017699
 protein coding gene Chr11:55934000-56271359 (+)



Homology
more
  • Human Ortholog
    GRIA1, glutamate ionotropic receptor AMPA type subunit 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GRIA1, glutamate ionotropic receptor AMPA type subunit 1
  • Synonyms
    GluA1, GLUH1, GLUR1, GLURA, HBGR1, MRD67, MRT76
  • Links
    NCBI Gene ID: 2890
    UniProt: P42261

  • Chr Location
    5q33.2; chr5:153489615-153813869 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Gria1 mouse models; 3 with human GRIA1 associations

Human Disease Mouse Models
      
IDs
 View 2 models
      
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    57 phenotypes from 12 alleles in 12 genetic backgrounds
    149 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice with mutations in phosphorylation sites have LTD and LTP deficits and spatial learning memory defects. Null homozygotes also show stimulus-reward learning deficits and increases locomotor activity and context-dependent sensitization to amphetamine.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    277
  • GO References
    52
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1194
  • Tissues
    199
  • cDNA Data
    58
  • Literature Summary
    72
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 14799 NCBI Gene Model | MGI Sequence Detail 318729 C57BL/6J ±  kb
    transcript NM_001113325 RefSeq | MGI Sequence Detail 5755 ZRU/MplStud  
    polypeptide P23818 UniProt | EBI | MGI Sequence Detail 907 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      11 Sequences
    • Protein Ontology
      PR:000008233 glutamate receptor 1
      (term hierarchy)
    • PDB
      7LDD, 7LDE
    • InterPro Domains
      IPR015683 Ionotropic glutamate receptor
      IPR001320 Ionotropic glutamate receptor, C-terminal
      IPR019594 Ionotropic glutamate receptor, L-glutamate and glycine-binding domain
      IPR001508 Ionotropic glutamate receptor, metazoa
      IPR028082 Periplasmic binding protein-like I
      IPR001828 Receptor, ligand binding region
    • GlyGen
      P23818 7 sites, 10 N-linked glycans (6 sites), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 65
      cDNA 61
      Primer pair 3
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-10128, MGD-MRK-10129, MGD-MRK-10140, MGD-MRK-10147, MGD-MRK-10246, MGI:1920245, MGI:2144316, MGI:95746
    References
    more
    • Summaries
      All 395
      Developmental Gene Expression 72
      Diseases 1
      Gene Ontology 52
      Phenotypes 149
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:363654 Wang J, et al., Cortex-Specific Tmem169 Deficiency Induces Defects in Cortical Neuron Development and Autism-Like Behaviors in Mice. J Neurosci. 2025 Feb 26;45(9)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Send questions and comments to User Support.     		last database update
    03/25/2025
    MGI 6.24     		The Jackson Laboratory