Gria1
Gene Detail

Symbol Name ID

Gria1 glutamate receptor, ionotropic, AMPA1 (alpha 1) MGI:95808

Synonyms

2900051M01Rik, Glr1, Glr-1, GluA1, Glur1, Glur-1, GluR1, GluRA, GluR-A, HIPA1

Feature Type

protein coding gene

Genetic Map

Chromosome 11

34.51 cM
Detailed Genetic Map ± 1 cM


Mapping data(10)

Sequence Map

Chr11:57011387-57330244 bp, + strand From VEGA annotation of GRCm38   318858 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:20226  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Protein SuperFamily: ionotropic glutamate receptor, AMPA/kainate types
Gene Tree: Gria1

Human homologs

Human Homolog		GRIA1, glutamate receptor, ionotropic, AMPA 1
NCBI Gene ID		2890
neXtProt AC		NX_P42261
Human Synonyms		GluA1, GLUH1, GLUR1, GLURA, HBGR1
Human Chr (Location)		5q31.1; chr5:153490524-153813869 (+)  GRCh38

Alleles and phenotypes

All alleles(10) : Targeted(10)
 

Mice with mutations in phosphorylation sites have LTD and LTP deficits and spatial learning memory defects. Null homozygotes also show stimulus-reward learning deficits and increases locomotor activity and context-dependent sensitization to amphetamine.

 

Gene Ontology (GO) classifications

All GO classifications: (82 annotations)

Process	ionotropic glutamate receptor signaling pathway, ion transmembrane transport, ...
Component	alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid selective glutamate receptor complex, asymmetric synapse, ...
Function	adenylate cyclase binding, alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity, ...

External Resources: FuncBase

Expression

Literature Summary: (30 records)

Data Summary: Results (393)    Tissues (157)    Images (52)
Theiler Stages: 20, 22, 23, 26, 28

Assay Type	Results
Immunohistochemistry	3
RNA in situ	340
Western blot	4
RT-PCR	46

cDNA source data(55)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(59) cDNA(57) Primer pair(2)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000005703 (Evidence)
Ensembl Gene Model	ENSMUSG00000020524 (Evidence)
Entrez Gene	14799 (Evidence)
UniGene	4920
DFCI	TC1579312, TC1623057, TC1715454
DoTS	DT.40170629, DT.60103679, DT.97402379
NIA Mouse Gene Index	U012637
Consensus CDS Project	CCDS36159.1, CCDS48800.1, CCDS56770.1
International Mouse Knockout Project Status	Gria1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000005703	VEGA Gene Model | MGI Sequence Detail	318858	C57BL/6J
transcript	OTTMUST00000012688	VEGA | MGI Sequence Detail	5546	Not Applicable
polypeptide	OTTMUSP00000005878	VEGA | MGI Sequence Detail	907	Not Applicable

All sequences(66) RefSeq(9) UniProt(11)

Polymorphisms

RFLP(2) : SNPs within 2kb(2770 from dbSNP Build 137)

Protein-related information

Resource	ID	Description
InterPro	IPR001828	Extracellular ligand-binding receptor
InterPro	IPR001638	Extracellular solute-binding protein, family 3
InterPro	IPR019594	Glutamate receptor, L-glutamate/glycine-binding
InterPro	IPR001320	Ionotropic glutamate receptor
InterPro	IPR001508	NMDA receptor
Protein Ontology	PR:000008233	glutamate receptor 1

References

(Earliest) J:10801 Sakimura K, et al., Functional expression from cloned cDNAs of glutamate receptor species responsive to kainate and quisqualate. FEBS Lett. 1990 Oct 15;272(1-2):73-80
(Latest) J:207045 Procaccini C, et al., Reversal of novelty-induced hyperlocomotion and hippocampal c-Fos expression in GluA1 knockout male mice by the mGluR2/3 agonist LY354740. Neuroscience. 2013 Oct 10;250:189-200
All references(201)

Other accession IDs

MGD-MRK-10128, MGD-MRK-10129, MGD-MRK-10140, MGD-MRK-10147, MGD-MRK-10246, MGI:1920245, MGI:2144316, MGI:95746