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Gria1
Gene Detail
Symbol

Name
ID
Gria1
glutamate receptor, ionotropic, AMPA1 (alpha 1)
MGI:95808
Synonyms
2900051M01Rik, Glr1, Glr-1, GluA1, Glur1, Glur-1, GluR1, GluRA, GluR-A, HIPA1
Feature Type
protein coding gene
Genetic Map
Chromosome 11
34.51 cM
Detailed Genetic Map ± 1 cM


Mapping data(10)
Sequence Map
Chr11:57011387-57330244 bp, + strand
From VEGA annotation of GRCm38

  318858 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20226  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

Protein SuperFamily: ionotropic glutamate receptor, AMPA/kainate types
Gene Tree: Gria1

Human
homologs
Human Homolog GRIA1, glutamate receptor, ionotropic, AMPA 1
NCBI Gene ID 2890
neXtProt AC  NX_P42261
Human Synonyms  GluA1, GLUH1, GLUR1, GLURA, HBGR1
Human Chr (Location)  5q31.1; chr5:153490524-153813869 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(11) : Targeted(11)
Incidental mutations (data from Mutagenetix , APF )
 
Mice with mutations in phosphorylation sites have LTD and LTP deficits and spatial learning memory defects. Null homozygotes also show stimulus-reward learning deficits and increases locomotor activity and context-dependent sensitization to amphetamine.
 
Interactions
Gria1 interacts with 346 markers (Mir1b, Mir7-1, Mir7-2, ...)
Expression
Literature Summary: (31 records)
Data Summary: Results (393)    Tissues (157)    Images (52)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 3
RNA in situ 340
Western blot 4
RT-PCR 46
cDNA source data(55)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(59) cDNA(57) Primer pair(2)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000005703 (Evidence)
Ensembl Gene ModelENSMUSG00000020524 (Evidence)
Entrez Gene14799 (Evidence)
UniGene4920
DFCITC1579312, TC1623057, TC1715454
DoTSDT.40170629, DT.60103679, DT.97402379
NIA Mouse Gene IndexU012637
Consensus CDS ProjectCCDS36159.1, CCDS48800.1, CCDS56770.1
International Mouse Knockout Project StatusGria1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005703 VEGA Gene Model | MGI Sequence Detail 318858 C57BL/6J ±  kb
transcript OTTMUST00000012688 VEGA | MGI Sequence Detail 5546 Not Applicable 
polypeptide OTTMUSP00000005878 VEGA | MGI Sequence Detail 907 Not Applicable 

For the selected sequences
All sequences(66) RefSeq(9) UniProt(11)
Polymorphisms
RFLP(2) : SNPs within 2kb(2770 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001828 Extracellular ligand-binding receptor
InterPro IPR001638 Extracellular solute-binding protein, family 3
InterPro IPR019594 Glutamate receptor, L-glutamate/glycine-binding
InterPro IPR001320 Ionotropic glutamate receptor
InterPro IPR001508 NMDA receptor
Protein Ontology PR:000008233 glutamate receptor 1
References
(Earliest) J:10801 Sakimura K, et al., Functional expression from cloned cDNAs of glutamate receptor species responsive to kainate and quisqualate. FEBS Lett. 1990 Oct 15;272(1-2):73-80
(Latest) J:210602 Lewitus GM, et al., An adaptive role of TNFalpha in the regulation of striatal synapses. J Neurosci. 2014 Apr 30;34(18):6146-55
All references(205)
Other
accession IDs
MGD-MRK-10128, MGD-MRK-10129, MGD-MRK-10140, MGD-MRK-10147, MGD-MRK-10246, MGI:1920245, MGI:2144316, MGI:95746

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory