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Gria1 Gene Detail
Summary
  • Symbol
    Gria1
  • Name
    glutamate receptor, ionotropic, AMPA1 (alpha 1)
  • Synonyms
    2900051M01Rik, Glr1, Glr-1, GluA1, Glur1, Glur-1, GluR1, GluRA, GluR-A, HIPA1
  • Feature Type
    protein coding gene
  • IDs
    MGI:95808
    NCBI Gene: 14799
  • Gene Overview
    MyGene.info: GRIA1
  • Alliance
    gene page
Location & Maps
more
  • Sequence Map
    Chr11:57011387-57330244 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      318858 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 34.51 cM
  • Mapping Data
    11 experiments
Homology
more
  • Human Ortholog
    GRIA1, glutamate ionotropic receptor AMPA type subunit 1
  • Vertebrate Orthologs
    11
  • Human Ortholog
    GRIA1, glutamate ionotropic receptor AMPA type subunit 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    GluA1, GLUH1, GLUR1, GLURA, HBGR1
  • Links
    NCBI Gene ID: 2890
    neXtProt AC: NX_P42261
    UniProt: P42261

  • Chr Location
    5q33.2; chr5:153489615-153813873 (+)  GRCh38.p7
Human Diseases
more
  • Diseases
    1 with Gria1 mouse models

Human Disease Mouse Models
      
IDs
 View 2 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    40 phenotypes from 10 alleles in 10 genetic backgrounds
    98 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice with mutations in phosphorylation sites have LTD and LTP deficits and spatial learning memory defects. Null homozygotes also show stimulus-reward learning deficits and increases locomotor activity and context-dependent sensitization to amphetamine.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    112
  • GO References
    35
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    404
  • Tissues
    160
  • cDNA Data
    57
  • Literature Summary
    44
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000005703 VEGA Gene Model | MGI Sequence Detail 318858 C57BL/6J ±  kb
    transcript OTTMUST00000012688 VEGA | MGI Sequence Detail 5546 Not Applicable  
    polypeptide OTTMUSP00000005878 VEGA | MGI Sequence Detail 907 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      2743 from dbSNP Build 142
    • RFLP
      2
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 62
      cDNA 59
      Primer pair 2
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-10128, MGD-MRK-10129, MGD-MRK-10140, MGD-MRK-10147, MGD-MRK-10246, MGI:1920245, MGI:2144316, MGI:95746
    References
    more
    • Summaries
      All 284
      Developmental Gene Expression 44
      Diseases 1
      Gene Ontology 35
      Phenotypes 98
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:262575 Jahn HM, et al., Refined protocols of tamoxifen injection for inducible DNA recombination in mouse astroglia. Sci Rep. 2018 Apr 12;8(1):5913
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/11/2018
    MGI 6.12     		The Jackson Laboratory