Gria1 MGI Mouse Gene Detail - MGI:95808 - glutamate receptor, ionotropic, AMPA1 (alpha 1)

Symbol

Gria1
Name

glutamate receptor, ionotropic, AMPA1 (alpha 1)
Synonyms

2900051M01Rik, Glr1, Glr-1, GluA1, Glur1, Glur-1, GluR1, GluRA, GluR-A, HIPA1

Feature Type

protein coding gene
IDs

MGI:95808
NCBI Gene: 14799
Gene Overview

MyGene.info: GRIA1
Alliance

gene page
Transcription Start Sites

8 TSS

Sequence Map

Chr11:57011571-57330244 bp, + strand
From NCBI annotation of GRCm38

View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 11, 34.51 cM
Mapping Data

11 experiments

SNPs within 2kb

2743 from dbSNP Build 142
Strain Annotations

18
RFLP

2

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_95808	protein coding gene	Chr11:57011387-57330244 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0018335	protein coding gene	Chr11:56600237-56934078 (+)
A/J	MGP_AJ_G0018304	protein coding gene	Chr11:54480133-54804874 (+)
AKR/J	MGP_AKRJ_G0018273	protein coding gene	Chr11:56275670-56604138 (+)
BALB/cJ	MGP_BALBcJ_G0018275	protein coding gene	Chr11:54823098-55145078 (+)
C3H/HeJ	MGP_C3HHeJ_G0018087	protein coding gene	Chr11:56208253-56533893 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0018727	protein coding gene	Chr11:58321471-58673305 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0016377	protein coding gene	Chr11:51860638-52182339 (+)
CAST/EiJ	MGP_CASTEiJ_G0017651	protein coding gene	Chr11:56248438-56579756 (+)
CBA/J	MGP_CBAJ_G0018061	protein coding gene	Chr11:61047242-61394002 (+)
DBA/2J	MGP_DBA2J_G0018170	protein coding gene	Chr11:54135734-54459911 (+)
FVB/NJ	MGP_FVBNJ_G0018162	protein coding gene	Chr11:53819644-54139445 (+)
LP/J	MGP_LPJ_G0018245	protein coding gene	Chr11:57088233-57429872 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0018188	protein coding gene	Chr11:62211997-62547823 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0018769	protein coding gene	Chr11:56289294-56611542 (+)
PWK/PhJ	MGP_PWKPhJ_G0017424	protein coding gene	Chr11:54731182-55051492 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0017219	protein coding gene	Chr11:56173401-56494207 (+)
WSB/EiJ	MGP_WSBEiJ_G0017699	protein coding gene	Chr11:55934000-56271359 (+)

Human Ortholog

GRIA1, glutamate ionotropic receptor AMPA type subunit 1

Vertebrate Orthologs

11

Human Ortholog

GRIA1, glutamate ionotropic receptor AMPA type subunit 1
Orthology source: HomoloGene, HGNC
Synonyms

GluA1, GLUH1, GLUR1, GLURA, HBGR1
Links

HGNC:4571

NCBI Gene ID: 2890

neXtProt AC: NX_P42261

UniProt: P42261
Chr Location

5q33.2; chr5:153489615-153813873 (+) GRCh38.p7

HomoloGene

Vertebrate Homology Class 20226
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;2 zebrafish;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: GRIA1
Protein SuperFamily

ionotropic glutamate receptor, AMPA/kainate types
Gene Tree

Gria1

Diseases

1 with Gria1 mouse models

Human Disease

Mouse Models

schizoaffective disorder

IDs

View 2 models

Click on a disease name to see all genes associated with that disease.

Mutations/Alleles

1 with disease annotations

References

1 with disease annotations

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Phenotype Summary

52 phenotypes from 12 alleles in 12 genetic backgrounds
119 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

18
Chemically induced (other)

1
Endonuclease-mediated

2
Targeted

13
Transgenic

2
Genomic Mutations

1 involving Gria1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

11 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice with mutations in phosphorylation sites have LTD and LTP deficits and spatial learning memory defects. Null homozygotes also show stimulus-reward learning deficits and increases locomotor activity and context-dependent sensitization to amphetamine.

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All GO Annotations

121
GO References

38

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1047
Tissues

163
cDNA Data

57
Literature Summary

54

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase gria1

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Gria1 interacts with 345 markers (Mir1b, Mir7-1, Mir7-2, ...) View All

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All Sequences

69
RefSeq

11
UniProt

11
CCDS

CCDS36159.1, CCDS48800.1, CCDS56770.1
UniGene

4920

Ensembl

ENSMUSG00000020524 (Evidence)
NCBI Gene

14799

			Length	Strain/Species	Flank
genomic	14799	NCBI Gene Model \| MGI Sequence Detail	318674	C57BL/6J	± kb
transcript	NM_001113325	RefSeq \| MGI Sequence Detail	5755	C57BL/6
polypeptide	P23818	UniProt \| EBI \| MGI Sequence Detail	907	Not Applicable

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UniProt

11 Sequences
Protein Ontology

PR:000008233 glutamate receptor 1

(term hierarchy)
InterPro Domains

IPR001320 Ionotropic glutamate receptor

IPR019594 Ionotropic glutamate receptor, L-glutamate and glycine-binding domain

IPR001508 Ionotropic glutamate receptor, metazoa

IPR028082 Periplasmic binding protein-like I

IPR001828 Receptor, ligand binding region

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All nucleic 62

cDNA 59

Primer pair 2

Other 1

Microarray probesets 3

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MGD-MRK-10128, MGD-MRK-10129, MGD-MRK-10140, MGD-MRK-10147, MGD-MRK-10246, MGI:1920245, MGI:2144316, MGI:95746

Summaries

All 322

Developmental Gene Expression 54

Diseases 1

Gene Ontology 38

Phenotypes 119
Earliest

J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
Latest

J:284925 Luo L, et al., Optimizing Nervous System-Specific Gene Targeting with Cre Driver Lines: Prevalence of Germline Recombination and Influencing Factors. Neuron. 2020 Feb 5;

TSS for Gria1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr101628	Chr11:57011559-57011587 (+)	2 bp
Tssr101629	Chr11:57011707-57011718 (+)	142 bp
Tssr101630	Chr11:57011724-57011735 (+)	159 bp
Tssr101631	Chr11:57011743-57011782 (+)	192 bp
Tssr101632	Chr11:57011798-57011827 (+)	242 bp
Tssr101633	Chr11:57011832-57011843 (+)	267 bp
Tssr101634	Chr11:57011945-57011946 (+)	375 bp
Tssr101635	Chr11:57012747-57012785 (+)	1,195 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 08/04/2020 MGI 6.15