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Gria1 Gene Detail
Summary
  • Symbol
    Gria1
  • Name
    glutamate receptor, ionotropic, AMPA1 (alpha 1)
  • Synonyms
    2900051M01Rik, Glr1, Glr-1, GluA1, Glur1, Glur-1, GluR1, GluRA, GluR-A, HIPA1
  • Feature Type
    protein coding gene
  • IDs
    MGI:95808
    NCBI Gene: 14799
  • Gene Overview
    MyGene.info: GRIA1
Location & Maps
more
  • Sequence Map
    Chr11:57011387-57330244 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      318858 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 34.51 cM
  • Mapping Data
    10 experiments
Homology
more
  • Human Ortholog
    GRIA1, glutamate ionotropic receptor AMPA type subunit 1
  • Vertebrate Orthologs
    11
  • Human Ortholog
    GRIA1, glutamate ionotropic receptor AMPA type subunit 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    GluA1, GLUH1, GLUR1, GLURA, HBGR1
  • Links
    NCBI Gene ID: 2890
    neXtProt AC: NX_P42261
    UniProt: P42261

  • Chr Location
    5q33.2; chr5:153489615-153813873 (+)  GRCh38.p7
Human Diseases
more
  • Diseases
    1 with Gria1 mouse models

Human Disease Mouse Models
      
IDs
 View 2 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    40 phenotypes from 10 alleles in 10 genetic backgrounds
    83 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice with mutations in phosphorylation sites have LTD and LTP deficits and spatial learning memory defects. Null homozygotes also show stimulus-reward learning deficits and increases locomotor activity and context-dependent sensitization to amphetamine.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    97
  • GO References
    32
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    393
  • Tissues
    157
  • cDNA Data
    55
  • Literature Summary
    38
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005703 VEGA Gene Model | MGI Sequence Detail 318858 C57BL/6J ±  kb
transcript OTTMUST00000012688 VEGA | MGI Sequence Detail 5546 Not Applicable  
polypeptide OTTMUSP00000005878 VEGA | MGI Sequence Detail 907 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    2743 from dbSNP Build 142
  • RFLP
    2
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 59
    cDNA 57
    Primer pair 2

    Microarray probesets 3
Other
Accession IDs
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MGD-MRK-10128, MGD-MRK-10129, MGD-MRK-10140, MGD-MRK-10147, MGD-MRK-10246, MGI:1920245, MGI:2144316, MGI:95746
References
more
  • Summaries
    All 232
    Developmental Gene Expression 38
    Diseases 1
    Gene Ontology 32
    Phenotypes 83
  • Earliest
    J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
  • Latest
    J:242043 Zhu J, et al., Epilepsy-associated gene Nedd4-2 mediates neuronal activity and seizure susceptibility through AMPA receptors. PLoS Genet. 2017 Feb;13(2):e1006634
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/19/2017
MGI 6.10 		The Jackson Laboratory