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Gria1 Gene Detail
Summary
  • Symbol
    Gria1
  • Name
    glutamate receptor, ionotropic, AMPA1 (alpha 1)
  • Synonyms
    2900051M01Rik, Glr1, Glr-1, GluA1, Glur1, Glur-1, GluR1, GluRA, GluR-A, HIPA1
  • Feature Type
    protein coding gene
  • IDs
    MGI:95808
    NCBI Gene: 14799
  • Alliance
    gene page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:56902342-57221070 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 34.51 cM
  • Mapping Data
    11 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2708 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95808
 protein coding gene Chr11:56902213-57221070 (+)
129S1/SvImJ MGP_129S1SvImJ_G0018335
 protein coding gene Chr11:56600237-56934078 (+)
A/J MGP_AJ_G0018304
 protein coding gene Chr11:54480133-54804874 (+)
AKR/J MGP_AKRJ_G0018273
 protein coding gene Chr11:56275670-56604138 (+)
BALB/cJ MGP_BALBcJ_G0018275
 protein coding gene Chr11:54823098-55145078 (+)
C3H/HeJ MGP_C3HHeJ_G0018087
 protein coding gene Chr11:56208253-56533893 (+)
C57BL/6NJ MGP_C57BL6NJ_G0018727
 protein coding gene Chr11:58321471-58673305 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0016377
 protein coding gene Chr11:51860638-52182339 (+)
CAST/EiJ MGP_CASTEiJ_G0017651
 protein coding gene Chr11:56248438-56579756 (+)
CBA/J MGP_CBAJ_G0018061
 protein coding gene Chr11:61047242-61394002 (+)
DBA/2J MGP_DBA2J_G0018170
 protein coding gene Chr11:54135734-54459911 (+)
FVB/NJ MGP_FVBNJ_G0018162
 protein coding gene Chr11:53819644-54139445 (+)
LP/J MGP_LPJ_G0018245
 protein coding gene Chr11:57088233-57429872 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0018188
 protein coding gene Chr11:62211997-62547823 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0018769
 protein coding gene Chr11:56289294-56611542 (+)
PWK/PhJ MGP_PWKPhJ_G0017424
 protein coding gene Chr11:54731182-55051492 (+)
SPRET/EiJ MGP_SPRETEiJ_G0017219
 protein coding gene Chr11:56173401-56494207 (+)
WSB/EiJ MGP_WSBEiJ_G0017699
 protein coding gene Chr11:55934000-56271359 (+)



Homology
more
  • Human Ortholog
    GRIA1, glutamate ionotropic receptor AMPA type subunit 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GRIA1, glutamate ionotropic receptor AMPA type subunit 1
  • Synonyms
    GluA1, GLUH1, GLUR1, GLURA, HBGR1
  • Links
    NCBI Gene ID: 2890
    neXtProt AC: NX_P42261
    UniProt: P42261

  • Chr Location
    5q33.2; chr5:153489615-153813873 (+)  GRCh38.p7
Human Diseases
more
  • Diseases
    1 with Gria1 mouse models

Human Disease Mouse Models
      
IDs
 View 2 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    55 phenotypes from 12 alleles in 12 genetic backgrounds
    129 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice with mutations in phosphorylation sites have LTD and LTP deficits and spatial learning memory defects. Null homozygotes also show stimulus-reward learning deficits and increases locomotor activity and context-dependent sensitization to amphetamine.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    126
  • GO References
    44
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1128
  • Tissues
    186
  • cDNA Data
    57
  • Literature Summary
    63
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 14799 NCBI Gene Model | MGI Sequence Detail 318729 C57BL/6J ±  kb
    transcript NM_001113325 RefSeq | MGI Sequence Detail 5755 C57BL/6  
    polypeptide P23818 UniProt | EBI | MGI Sequence Detail 907 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 63
      cDNA 60
      Primer pair 2
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-10128, MGD-MRK-10129, MGD-MRK-10140, MGD-MRK-10147, MGD-MRK-10246, MGI:1920245, MGI:2144316, MGI:95746
    References
    more
    • Summaries
      All 355
      Developmental Gene Expression 63
      Diseases 1
      Gene Ontology 44
      Phenotypes 129
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:322955 Kilonzo K, et al., Distinct contributions of GluA1-containing AMPA receptors of different hippocampal subfields to salience processing, memory and impulse control. Transl Psychiatry. 2022 Mar 14;12(1):102
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    06/14/2022
    MGI 6.19     		The Jackson Laboratory