Phenotypes Associated with This Genotype

Genotype
MGI:4888960

• Allelic Composition: Gria1^tm1Rsp/Gria1^tm1Rsp
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * CBA/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal emotion/affect behavior ( J:167264 )

• in the elevated plus-maze, mutants make more open and center entries and have more center time but less closed time, than wild-type mice

• mutants exhibit a decrease in immobility compared to wild-type during the first and sometimes second forced swim trials

• mutants, but not wild-type mice, exhibit a significant increase in immobility by the third forced swim trial, as compared to trial 1

• mutants show less immobility and increased swimming, but no difference in climbing, in a modified forced swim test compared to wild-type mice on trial 1 but not trial 2

• mutants, but not wild-type mice, exhibit an increase in immobility and a decrease in swimming from trial 1 to 2 of the modified forced swim test

• all these behaviors are indicative of manic-like phenotype

increased exploration in new environment ( J:167264 )

• mutants travel farther than wild-type mice in a novel open field

• however, movement in a home cage-like environment is no different from wild-type

hyperactivity ( J:167264 )

• in a novel open field

induced hyperactivity ( J:167264 )

• injection stress produces a transient increase in activity in mutants compared to a decrease in locomotor activity in wild-type mice

• restraint stress produces a greater increase in locomotor activity in mutants than in wild-type mice

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:167264 )

N • corticosterone levels are similar in mutants as in wild-type after a single forced swim trial

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
schizoaffective disorder		DOID:5418		J:167264