About   Help   FAQ
Gnb1 Gene Detail
Summary
  • Symbol
    Gnb1
  • Name
    guanine nucleotide binding protein (G protein), beta 1
  • Feature Type
    protein coding gene
  • IDs
    MGI:95781
    NCBI Gene: 14688
  • Gene Overview
    MyGene.info: GNB1
Location & Maps
more
  • Sequence Map
    Chr4:155491364-155559269 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      67906 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 86.17 cM
  • Mapping Data
    15 experiments
Homology
more
  • Human Ortholog
    GNB1, G protein subunit beta 1
  • Vertebrate Orthologs
    12
  • Human Ortholog
    GNB1, G protein subunit beta 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    MRD42
  • Links
    NCBI Gene ID: 2782
    neXtProt AC: NX_P62873
    UniProt: P62873

  • Chr Location
    1p36.33; chr1:1785285-1891117 (-)  GRCh38.p7
Human Diseases
more
  • Diseases
    1 with human GNB1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    14 phenotypes from 1 allele in 1 genetic background
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Heterozygous null mice have an abnormal retina morphology with progressive degeneration. Mice homozygous for a mutation of this gene show prenatal or perinatal lethality with exencephaly and/or small brain.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    34
  • GO References
    15
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    94
  • Tissues
    77
  • cDNA Data
    13
  • Literature Summary
    11
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000010708 VEGA Gene Model | MGI Sequence Detail 67906 C57BL/6J ±  kb
transcript OTTMUST00000099383 VEGA | MGI Sequence Detail 3088 Not Applicable  
polypeptide OTTMUSP00000055795 VEGA | MGI Sequence Detail 340 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    476 from dbSNP Build 142
  • RFLP
    4
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 21
    Genomic 1
    cDNA 15
    Primer pair 4
    Other 1

    Microarray probesets 7
Other
Accession IDs
less
MGD-MRK-10195, MGD-MRK-10200, MGI:2140144, MGI:2140659
References
more
  • Summaries
    All 81
    Developmental Gene Expression 11
    Gene Ontology 15
    Phenotypes 16
  • Earliest
    J:12496 Kozak C, et al., Chromosome assignment in the mouse of the genes for several proteins involved in visual transduction. Cytogenet Cell Genet. 1989;51:1025-1026
  • Latest
    J:234197 Wong BH, et al., Mfsd2a Is a Transporter for the Essential omega-3 Fatty Acid Docosahexaenoic Acid (DHA) in Eye and Is Important for Photoreceptor Cell Development. J Biol Chem. 2016 May 13;291(20):10501-14
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support. 		last database update
06/20/2017
MGI 6.10 		The Jackson Laboratory