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Gnb1
Gene Detail
Symbol

Name
ID
Gnb1
guanine nucleotide binding protein (G protein), beta 1
MGI:95781
Feature Type
protein coding gene
Genetic Map
Chromosome 4
86.17 cM
Detailed Genetic Map ± 1 cM


Mapping data(15)
Sequence Map
Chr4:155491364-155559269 bp, + strand
From VEGA annotation of GRCm38

  67906 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:55532  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 3 zebrafish

HCOP human homology predictions: GNB1
Protein SuperFamily: guanine nucleotide-binding protein, beta subunit
Gene Tree: Gnb1

Human
homologs
GNB1, guanine nucleotide binding protein (G protein), beta polypeptide 1
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 2782
neXtProt AC: NX_P62873

Human Chr (Location): 1p36.33; chr1:1785285-1891117 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(77) : Gene trapped(75) Radiation induced(1) Targeted(1)
Genomic Mutations involving Gnb1 (1)
Incidental mutations (data from Mutagenetix , APF )
 
Heterozygous null mice have an abnormal retina morphology with progressive degeneration. Mice homozygous for a mutation of this gene show prenatal or perinatal lethality with exencephaly and/or small brain.
 
Interactions
Gnb1 interacts with 275 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (32 annotations)
Process cardiac muscle cell apoptotic process, cell proliferation, ...
Component cell body, cytosol, ...
Function G-protein coupled receptor binding, GTPase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (9 records)
Data Summary: Results (94)    Tissues (77)    Images (15)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 2
RNA in situ 7
In situ reporter (knock in) 10
Western blot 3
RT-PCR 72
cDNA source data(13)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase gnb1 ; ZFIN gnb1a, gnb1b    NEW 
Molecular
reagents
All nucleic(21) Genomic(1) cDNA(15) Primer pair(4) Other(1)
Microarray probesets(7)
Other database
links
VEGA Gene Model OTTMUSG00000010708 (Evidence)
Ensembl Gene Model ENSMUSG00000029064 (Evidence)
Entrez Gene 14688 (Evidence)
DFCI TC1573395, TC1593510, TC1595603, TC1606656, TC1646287
DoTS DT.101707166, DT.110772428, DT.87054719, DT.91283215, DT.91344716, DT.94370519
NIA Mouse Gene Index U042607
Consensus CDS Project CCDS19030.1
International Mouse Phenotyping Consortium Status Gnb1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000010708 VEGA Gene Model | MGI Sequence Detail 67906 C57BL/6J ±  kb
transcript OTTMUST00000099389 VEGA | MGI Sequence Detail 2832 Not Applicable 
polypeptide OTTMUSP00000055798 VEGA | MGI Sequence Detail 340 Not Applicable 

For the selected sequences
All sequences(96) RefSeq(6) UniProt(6)
Polymorphisms
RFLP(4) : SNPs within 2kb(483 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001632 G-protein, beta subunit
InterPro IPR020472 G-protein beta WD-40 repeat
InterPro IPR016346 Guanine nucleotide-binding protein, beta subunit
InterPro IPR001680 WD40 repeat
InterPro IPR019775 WD40 repeat, conserved site
InterPro IPR017986 WD40-repeat-containing domain
InterPro IPR015943 WD40/YVTN repeat-like-containing domain
Protein Ontology PR:000008095 guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
References
(Earliest) J:12496 Kozak C, et al., Chromosome assignment in the mouse of the genes for several proteins involved in visual transduction. Cytogenet Cell Genet. 1989;51:1025-1026
(Latest) J:209852 Prandi S, et al., A subset of mouse colonic goblet cells expresses the bitter taste receptor Tas2r131. PLoS One. 2013;8(12):e82820
All references(74)
Other
accession IDs
MGD-MRK-10195, MGD-MRK-10200, MGI:2140144, MGI:2140659

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory