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Gnb1
Gene Detail
 Symbol
Name
ID
Gnb1
guanine nucleotide binding protein (G protein), beta 1
MGI:95781
Feature Type protein coding gene
Genetic Map
Chromosome 4
86.17 cM
Detailed Genetic Map ± 1 cM


Mapping data(15)
Sequence Map
Chr4:155491364-155559269 bp, + strand
From VEGA annotation of GRCm38

  67906 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:55532  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 western clawed frog; 3 zebrafish

Protein SuperFamily: guanine nucleotide-binding protein, beta subunit
Gene Tree: Gnb1

Human
homologs
Human Homolog GNB1, guanine nucleotide binding protein (G protein), beta polypeptide 1
NCBI Gene ID 2782
neXtProt AC  NX_P62873
Human Chr (Location)  1p36.33; chr1:1785285-1891117 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(76) : Gene trapped(75) Targeted(1)
Incidental mutations (data from Mutagenetix , APF )
 
The distal break point for the In(4)56Rk inversion is located within this gene. This inversion is associated with the phenotypic marker Rd4. These mice have an abnormal retanl morphology. Homozygous mutant of this gene results in prenatal or perinatal lethality with exencephaly or smaller brain.
 
Interactions
Gnb1 interacts with 276 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (32 annotations)
Process cardiac muscle cell apoptotic process, cell proliferation, ...
Component cell body, cytosol, ...
Function G-protein coupled receptor binding, GTPase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (9 records)
Data Summary: Results (94)    Tissues (71)    Images (15)
Theiler Stages: 1, 2, 3, 4, 14, 15, 17, 19, 22, 23, 28
Assay TypeResults
Immunohistochemistry 2
RNA in situ 7
In situ reporter (knock in) 10
Western blot 3
RT-PCR 72
cDNA source data(13)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(21) Genomic(1) cDNA(15) Primer pair(4) Other(1)
Microarray probesets(7)
Other database
links
VEGA Gene ModelOTTMUSG00000010708 (Evidence)
Ensembl Gene ModelENSMUSG00000029064 (Evidence)
Entrez Gene14688 (Evidence)
DFCITC1573395, TC1593510, TC1595603, TC1606656, TC1646287
DoTSDT.101707166, DT.110772428, DT.87054719, DT.91283215, DT.91344716, DT.94370519
NIA Mouse Gene IndexU042607
Consensus CDS ProjectCCDS19030.1
International Mouse Knockout Project StatusGnb1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000010708 VEGA Gene Model | MGI Sequence Detail 67906 C57BL/6J ±  kb
transcript OTTMUST00000099389 VEGA | MGI Sequence Detail 2832 Not Applicable 
polypeptide OTTMUSP00000055798 VEGA | MGI Sequence Detail 340 Not Applicable 

For the selected sequences
All sequences(96) RefSeq(6) UniProt(6)
Polymorphisms RFLP(4) : SNPs within 2kb(483 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001632 G-protein, beta subunit
InterPro IPR020472 G-protein beta WD-40 repeat
InterPro IPR016346 Guanine nucleotide-binding protein, beta subunit
InterPro IPR001680 WD40 repeat
InterPro IPR019775 WD40 repeat, conserved site
InterPro IPR017986 WD40-repeat-containing domain
InterPro IPR015943 WD40/YVTN repeat-like-containing domain
Protein Ontology PR:000008095 guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
References (Earliest) J:9413 Blatt C, et al., Chromosomal localization of genes encoding guanine nucleotide-binding protein subunits in mouse and human. Proc Natl Acad Sci U S A. 1988 Oct;85(20):7642-6
(Latest) J:209852 Prandi S, et al., A subset of mouse colonic goblet cells expresses the bitter taste receptor Tas2r131. PLoS One. 2013;8(12):e82820
All references(77)
Other
accession IDs
MGD-MRK-10195, MGD-MRK-10200, MGI:2140144, MGI:2140659

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/19/2014
MGI 5.19
The Jackson Laboratory