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Gnb1 Gene Detail
Summary
  • Symbol
    Gnb1
  • Name
    guanine nucleotide binding protein (G protein), beta 1
  • Feature Type
    protein coding gene
  • IDs
    MGI:95781
    NCBI Gene: 14688
  • Gene Overview
    MyGene.info: GNB1
Location & Maps
more
  • Sequence Map
    Chr4:155491364-155559269 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      67906 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 86.17 cM
  • Mapping Data
    15 experiments
Homology
more
  • Human Ortholog
    GNB1, G protein subunit beta 1
  • Vertebrate Orthologs
    12
  • Human Ortholog
    GNB1, G protein subunit beta 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    MRD42
  • Links
    NCBI Gene ID: 2782
    neXtProt AC: NX_P62873

  • Chr Location
    1p36.33; chr1:1785285-1891117 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    2 with human GNB1 associations

Human Disease Mouse Models
       Leukemia, Acute Lymphoblastic; ALL   OMIM: 613065
Mental Retardation, Autosomal Dominant 42; MRD42   OMIM: 616973
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    14 phenotypes from 1 allele in 1 genetic background
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    77
  • Gene trapped
    75
  • Radiation induced
    1
  • Targeted
    1
  • Genomic Mutations
    1 involving Gnb1
  • Incidental Mutations
Heterozygous null mice have an abnormal retina morphology with progressive degeneration. Mice homozygous for a mutation of this gene show prenatal or perinatal lethality with exencephaly and/or small brain.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000010708 VEGA Gene Model | MGI Sequence Detail 67906 C57BL/6J ±  kb
transcript OTTMUST00000099383 VEGA | MGI Sequence Detail 3088 Not Applicable  
polypeptide OTTMUSP00000055795 VEGA | MGI Sequence Detail 340 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    476 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    6 Sequences
  • Protein Ontology
    PR:000008095 guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
  • InterPro Domains
    IPR001632 G-protein, beta subunit
    IPR020472 G-protein beta WD-40 repeat
    IPR016346 Guanine nucleotide-binding protein, beta subunit
    IPR001680 WD40 repeat
    IPR019775 WD40 repeat, conserved site
    IPR017986 WD40-repeat-containing domain
    IPR015943 WD40/YVTN repeat-like-containing domain
Molecular
Reagents
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  • All nucleic 21
    Genomic 1
    cDNA 15
    Primer pair 4
    Other 1

    Microarray probesets 7
Other
Accession IDs
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MGD-MRK-10195, MGD-MRK-10200, MGI:2140144, MGI:2140659
References
more
  • Summaries
    All 74
    Developmental Gene Expression 10
    Gene Ontology 15
    Phenotypes 16
  • Earliest
    J:12496 Kozak C, et al., Chromosome assignment in the mouse of the genes for several proteins involved in visual transduction. Cytogenet Cell Genet. 1989;51:1025-1026
  • Latest
    J:209852 Prandi S, et al., A subset of mouse colonic goblet cells expresses the bitter taste receptor Tas2r131. PLoS One. 2013;8(12):e82820

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/13/2016
MGI 6.05
The Jackson Laboratory