Gnb1
Gene Detail

Symbol Name ID

Gnb1 guanine nucleotide binding protein (G protein), beta 1 MGI:95781

Feature Type

protein coding gene

Genetic Map

Chromosome 4

86.17 cM
Detailed Genetic Map ± 1 cM


Mapping data(15)

Sequence Map

Chr4:155491364-155559269 bp, + strand From VEGA annotation of GRCm38   67906 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:55532  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 3 zebrafish

Protein SuperFamily: guanine nucleotide-binding protein, beta subunit
Gene Tree: Gnb1

Human homologs

Human Homolog		GNB1, guanine nucleotide binding protein (G protein), beta polypeptide 1
NCBI Gene ID		2782
neXtProt AC		NX_P62873
Human Chr (Location)		1p36.33; chr1:1785285-1891117 (-)  GRCh38

Alleles and phenotypes

All alleles(76) : Gene trapped(75) Targeted(1)
Incidental mutations (data from Mutagenetix , APF )
 

The distal break point for the In(4)56Rk inversion is located within this gene. This inversion is associated with the phenotypic marker Rd4. These mice have an abnormal retanl morphology. Homozygous mutant of this gene results in prenatal or perinatal lethality with exencephaly or smaller brain.

 

Gene Ontology (GO) classifications

All GO classifications: (31 annotations)

Process	cardiac muscle cell apoptotic process, cell proliferation, ...
Component	cell body, dendrite, ...
Function	G-protein coupled receptor binding, GTPase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (8 records)

Data Summary: Results (91)    Tissues (71)    Images (14)
Theiler Stages: 1, 2, 3, 4, 14, 15, 17, 19, 22, 23, 28

Assay Type	Results
Immunohistochemistry	2
RNA in situ	7
In situ reporter (knock in)	10
Western blot	3
RT-PCR	69

cDNA source data(13)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(20) Genomic(1) cDNA(15) Primer pair(3) Other(1)
Microarray probesets(7)

Other database links

VEGA Gene Model	OTTMUSG00000010708 (Evidence)
Ensembl Gene Model	ENSMUSG00000029064 (Evidence)
Entrez Gene	14688 (Evidence)
DFCI	TC1573395, TC1593510, TC1595603, TC1606656, TC1646287
DoTS	DT.101707166, DT.110772428, DT.87054719, DT.91283215, DT.91344716, DT.94370519
NIA Mouse Gene Index	U042607
Consensus CDS Project	CCDS19030.1
International Mouse Knockout Project Status	Gnb1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000010708	VEGA Gene Model | MGI Sequence Detail	67906	C57BL/6J
transcript	OTTMUST00000099383	VEGA | MGI Sequence Detail	3088	Not Applicable
polypeptide	OTTMUSP00000055795	VEGA | MGI Sequence Detail	340	Not Applicable

All sequences(96) RefSeq(6) UniProt(6)

Polymorphisms

RFLP(4) : SNPs within 2kb(483 from dbSNP Build 137)

Protein-related information

Resource	ID	Description
InterPro	IPR001632	G-protein, beta subunit
InterPro	IPR020472	G-protein beta WD-40 repeat
InterPro	IPR016346	Guanine nucleotide-binding protein, beta subunit
InterPro	IPR001680	WD40 repeat
InterPro	IPR019775	WD40 repeat, conserved site
InterPro	IPR017986	WD40-repeat-containing domain
InterPro	IPR015943	WD40/YVTN repeat-like-containing domain
Protein Ontology	PR:000008095	guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1

References

(Earliest) J:9413 Blatt C, et al., Chromosomal localization of genes encoding guanine nucleotide-binding protein subunits in mouse and human. Proc Natl Acad Sci U S A. 1988 Oct;85(20):7642-6
(Latest) J:199579 Papal S, et al., The giant spectrin betaV couples the molecular motors to phototransduction and Usher syndrome type I proteins along their trafficking route. Hum Mol Genet. 2013 Sep 15;22(18):3773-88
All references(76)

Other accession IDs

MGD-MRK-10195, MGD-MRK-10200, MGI:2140144, MGI:2140659