Gnb1 MGI Mouse Gene Detail - MGI:95781 - guanine nucleotide binding protein (G protein), beta 1

Symbol

Gnb1
Name

guanine nucleotide binding protein (G protein), beta 1

Feature Type

protein coding gene
IDs

MGI:95781
NCBI Gene: 14688
Gene Overview

MyGene.info: GNB1
Alliance

gene page
Transcription Start Sites

11 TSS

Sequence Map

Chr4:155491361-155559269 bp, + strand
From Ensembl annotation of GRCm38

View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 4, 86.17 cM
Mapping Data

15 experiments

SNPs within 2kb

476 from dbSNP Build 142
Strain Annotations

18
RFLP

4

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_95781	protein coding gene	Chr4:155491300-155559269 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0029215	protein coding gene	Chr4:159826105-159901693 (+)
A/J	MGP_AJ_G0029180	protein coding gene	Chr4:153110274-153179036 (+)
AKR/J	MGP_AKRJ_G0029128	protein coding gene	Chr4:157269980-157342160 (+)
BALB/cJ	MGP_BALBcJ_G0029196	protein coding gene	Chr4:153580830-153652327 (+)
C3H/HeJ	MGP_C3HHeJ_G0028917	protein coding gene	Chr4:157815981-157890148 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0029645	protein coding gene	Chr4:165513905-165584092 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0026891	protein coding gene	Chr4:145402665-145467765 (+)
CAST/EiJ	MGP_CASTEiJ_G0028330	protein coding gene	Chr4:155256055-155330486 (+)
CBA/J	MGP_CBAJ_G0028879	protein coding gene	Chr4:170507442-170584306 (+)
DBA/2J	MGP_DBA2J_G0029028	protein coding gene	Chr4:153130479-153198681 (+)
FVB/NJ	MGP_FVBNJ_G0028992	protein coding gene	Chr4:152369232-152438704 (+)
LP/J	MGP_LPJ_G0029118	protein coding gene	Chr4:159747752-159819921 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0029019	protein coding gene	Chr4:173328501-173401916 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0029677	protein coding gene	Chr4:157891491-157966341 (+)
PWK/PhJ	MGP_PWKPhJ_G0028050	protein coding gene	Chr4:149265671-149336664 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0027884	protein coding gene	Chr4:152150288-152219526 (+)
WSB/EiJ	MGP_WSBEiJ_G0028410	protein coding gene	Chr4:158064028-158138253 (+)

Human Ortholog

GNB1, G protein subunit beta 1

Vertebrate Orthologs

12

Human Ortholog

GNB1, G protein subunit beta 1
Orthology source: HomoloGene, HGNC
Synonyms

MRD42
Links

HGNC:4396

NCBI Gene ID: 2782

neXtProt AC: NX_P62873

UniProt: P62873
Chr Location

1p36.33; chr1:1785285-1891117 (-) GRCh38.p7

HomoloGene

Vertebrate Homology Class 55532
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;3 zebrafish;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: GNB1
Protein SuperFamily

guanine nucleotide-binding protein, beta subunit
Gene Tree

Gnb1

Diseases

2 with human GNB1 associations

				Human Disease	Mouse Models
				acute lymphoblastic leukemia IDs acute lymphoblastic leukemia DOID:9952 DOID:5600 DOID:5600 DOID:5600 DOID:5600 EFO:0000220 ICD10CM:C91.00 ICD9CM:204.0 NCI:C3167 NCI:C7055 OMIM:247640 OMIM:613065 ORDO:513 UMLS_CUI:C0023449 UMLS_CUI:C1335469
				autosomal dominant non-syndromic intellectual disability 42 IDs autosomal dominant non-syndromic intellectual disability 42 DOID:0070072 OMIM:616973

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

19 phenotypes from 2 alleles in 2 genetic backgrounds
19 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

78
Endonuclease-mediated

1
Gene trapped

75
Radiation induced

1
Targeted

1
Genomic Mutations

1 involving Gnb1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

38 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Heterozygous null mice have an abnormal retina morphology with progressive degeneration. Mice homozygous for a mutation of this gene show prenatal or perinatal lethality with exencephaly and/or small brain.

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All GO Annotations

32
GO References

16

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

725
Tissues

77
cDNA Data

14
Literature Summary

13

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase gnb1

ZFIN gnb1a, gnb1b

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Gnb1 interacts with 275 markers (Mir1a-1, Mir1a-2, Mir1b, ...) View All

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All Sequences

90
RefSeq

8
UniProt

6
CCDS

CCDS19030.1

Ensembl

ENSMUSG00000029064 (Evidence)
NCBI Gene

14688

			Length	Strain/Species	Flank
genomic	ENSMUSG00000029064	Ensembl Gene Model \| MGI Sequence Detail	67909	C57BL/6J	± kb
transcript	ENSMUST00000105616	Ensembl \| MGI Sequence Detail	3088	Not Applicable
polypeptide	ENSMUSP00000101241	Ensembl \| MGI Sequence Detail	340	Not Applicable

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UniProt

6 Sequences
Protein Ontology

PR:000008095 guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1

(term hierarchy)
InterPro Domains

IPR001632 G-protein, beta subunit

IPR020472 G-protein beta WD-40 repeat

IPR016346 Guanine nucleotide-binding protein, beta subunit

IPR001680 WD40 repeat

IPR019775 WD40 repeat, conserved site

IPR017986 WD40-repeat-containing domain

IPR036322 WD40-repeat-containing domain superfamily

IPR015943 WD40/YVTN repeat-like-containing domain superfamily

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All nucleic 22

Genomic 1

cDNA 16

Primer pair 4

Other 1

Microarray probesets 7

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MGD-MRK-10195, MGD-MRK-10200, MGI:2140144, MGI:2140659

Summaries

All 96

Developmental Gene Expression 13

Gene Ontology 16

Phenotypes 19
Earliest

J:12496 Kozak C, et al., Chromosome assignment in the mouse of the genes for several proteins involved in visual transduction. Cytogenet Cell Genet. 1989;51:1025-1026
Latest

J:284450 Zurawski Z, et al., Disabling the Gbetagamma-SNARE interaction disrupts GPCR-mediated presynaptic inhibition, leading to physiological and behavioral phenotypes. Sci Signal. 2019 Feb 19;12(569)

TSS for Gnb1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr40644	Chr4:155491050-155491069 (+)	-301 bp
Tssr40645	Chr4:155491353-155491411 (+)	21 bp
Tssr40648	Chr4:155522529-155522543 (+)	31,175 bp
Tssr40649	Chr4:155522560-155522591 (+)	31,215 bp
Tssr40650	Chr4:155522592-155522622 (+)	31,246 bp
Tssr40652	Chr4:155543056-155543076 (+)	51,705 bp
Tssr40655	Chr4:155553418-155553435 (+)	62,066 bp
Tssr40656	Chr4:155555064-155555081 (+)	63,712 bp
Tssr40657	Chr4:155555146-155555192 (+)	63,808 bp
Tssr40664	Chr4:155558795-155558808 (+)	67,441 bp
Tssr40665	Chr4:155558958-155558981 (+)	67,609 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 05/19/2020 MGI 6.15