Gnb1 MGI Mouse Gene Detail - MGI:95781 - guanine nucleotide binding protein (G protein), beta 1

Gnb1 Gene Detail

Symbol

Gnb1
Name

guanine nucleotide binding protein (G protein), beta 1

Feature Type

protein coding gene
IDs

MGI:95781
NCBI Gene: 14688
Gene Overview

MyGene.info: GNB1

Sequence Map

Chr4:155491364-155559269 bp, + strand
From VEGA annotation of GRCm38

Mouse Genome Browser
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Sequence

67906 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 4, 86.17 cM
Mapping Data

15 experiments

Human Ortholog

GNB1, G protein subunit beta 1

Vertebrate Orthologs

12

Human Ortholog

GNB1, G protein subunit beta 1
Orthology source: HomoloGene, HGNC
Synonyms

MRD42
Links

HGNC:4396

NCBI Gene ID: 2782

neXtProt AC: NX_P62873

UniProt: P62873
Chr Location

1p36.33; chr1:1785285-1891117 (-) GRCh38.p7

HomoloGene

Vertebrate Homology Class 55532
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;3 zebrafish;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: GNB1
Protein SuperFamily

guanine nucleotide-binding protein, beta subunit
Gene Tree

Gnb1

Diseases

1 with human GNB1 associations

				Human Disease	Mouse Models
				acute lymphocytic leukemia IDs acute lymphocytic leukemia DOID:9952 EFO:0000220 ICD10CM:C91.0 ICD10CM:C91.00 ICD9CM:204.0 NCI:C3167 OMIM:247640 OMIM:613065 OMIM:613067 OMIM:615545 ORDO:513 UMLS_CUI:C0023449

Click on a disease name to see all genes associated with that disease.

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Phenotype Summary

14 phenotypes from 1 allele in 1 genetic background
16 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

77
Gene trapped

75
Radiation induced

1
Targeted

1
Genomic Mutations

1 involving Gnb1
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

50 strains or lines available

Heterozygous null mice have an abnormal retina morphology with progressive degeneration. Mice homozygous for a mutation of this gene show prenatal or perinatal lethality with exencephaly and/or small brain.

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All GO Annotations

34
GO References

15

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

94
Tissues

77
cDNA Data

13
Literature Summary

12

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase gnb1

ZFIN gnb1a, gnb1b

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Gnb1 interacts with 275 markers (Mir1a-1, Mir1a-2, Mir1b, ...) View All

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All Sequences

86
RefSeq

8
UniProt

6
CCDS

CCDS19030.1

			Length	Strain/Species	Flank
genomic	OTTMUSG00000010708	VEGA Gene Model \| MGI Sequence Detail	67906	C57BL/6J	± kb
transcript	OTTMUST00000099383	VEGA \| MGI Sequence Detail	3088	Not Applicable
polypeptide	OTTMUSP00000055795	VEGA \| MGI Sequence Detail	340	Not Applicable

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SNPs within 2kb

476 from dbSNP Build 142

RFLP

4

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UniProt

6 Sequences
Protein Ontology

PR:000008095 guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1

(term hierarchy)
InterPro Domains

IPR001632 G-protein, beta subunit

IPR020472 G-protein beta WD-40 repeat

IPR016346 Guanine nucleotide-binding protein, beta subunit

IPR011042 Six-bladed beta-propeller, TolB-like

IPR001680 WD40 repeat

IPR019775 WD40 repeat, conserved site

IPR017986 WD40-repeat-containing domain

IPR015943 WD40/YVTN repeat-like-containing domain

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All nucleic 21

Genomic 1

cDNA 15

Primer pair 4

Other 1

Microarray probesets 7

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MGD-MRK-10195, MGD-MRK-10200, MGI:2140144, MGI:2140659

Summaries

All 82

Developmental Gene Expression 12

Gene Ontology 15

Phenotypes 16
Earliest

J:12496 Kozak C, et al., Chromosome assignment in the mouse of the genes for several proteins involved in visual transduction. Cytogenet Cell Genet. 1989;51:1025-1026
Latest

J:242591 Guo Y, et al., Gbeta2 Regulates the Multipolar-Bipolar Transition of Newborn Neurons in the Developing Neocortex. Cereb Cortex. 2017 Jun 01;27(6):3414-3426

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 08/15/2017 MGI 6.10