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Gna11
Gene Detail
Symbol

Name
ID
Gna11
guanine nucleotide binding protein, alpha 11
MGI:95766
Synonyms
Dsk7
Feature Type
protein coding gene
Genetic Map
Chromosome 10
39.72 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr10:81528724-81545190 bp, - strand
From VEGA annotation of GRCm38

  16467 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20474  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: GNA11
Gene Tree: Gna11

Human
homologs
GNA11, guanine nucleotide binding protein (G protein), alpha 11 (Gq class)
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 2767
neXtProt AC: NX_P29992

Human Synonyms: FBH, FBH2, FHH2, GNA-11, HHC2, HYPOC2

Human Chr (Location): 19p13.3; chr19:3094410-3124002 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(9) : Chemically induced (ENU)(1) Gene trapped(6) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Mice deficient for this gene do not exhibit any detectable abnormalities.
 
Interactions
Gna11 interacts with 211 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (8 records)
Data Summary: Results (45)    Tissues (27)    Images (3)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 24
Western blot 6
RT-PCR 15
cDNA source data(12)
Other mouse links: GEO   Expression Atlas
Other vertebrate links: Xenbase gna11 ; ZFIN gna11a    NEW 
Molecular
reagents
All nucleic(25) Genomic(8) cDNA(12) Primer pair(4) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000030287 (Evidence)
Ensembl Gene Model ENSMUSG00000034781 (Evidence)
Entrez Gene 14672 (Evidence)
DFCI TC1575884
DoTS DT.110616071, DT.532777, DT.94189415
NIA Mouse Gene Index U052056
Consensus CDS Project CCDS24061.1
International Mouse Phenotyping Consortium Status Gna11
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000030287 VEGA Gene Model | MGI Sequence Detail 16467 C57BL/6J ±  kb
transcript OTTMUST00000074975 VEGA | MGI Sequence Detail 3414 Not Applicable 
polypeptide OTTMUSP00000039227 VEGA | MGI Sequence Detail 359 Not Applicable 

For the selected sequences
All sequences(35) RefSeq(2) UniProt(4)
Polymorphisms
RFLP(1) : SNPs within 2kb(44 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000654 G-protein alpha subunit, group Q
InterPro IPR011025 G protein alpha subunit, helical insertion
InterPro IPR001019 Guanine nucleotide binding protein (G-protein), alpha subunit
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
Protein Ontology PR:000008080 guanine nucleotide-binding protein subunit alpha-11
References
(Earliest) J:30942 Sewell JL, et al., Sequences of the bovine and yeast ADP-ribosylation factor and comparison to other GTP-binding proteins. Proc Natl Acad Sci U S A. 1988 Jul;85(13):4620-4
(Latest) J:220344 Szekeres M, et al., Endocannabinoid-mediated modulation of Gq/11 protein-coupled receptor signaling-induced vasoconstriction and hypertension. Mol Cell Endocrinol. 2015 Mar 5;403:46-56
All references(89)
Other
accession IDs
MGD-MRK-10175, MGI:2450689

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory