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Gna11 Gene Detail
Summary
  • Symbol
    Gna11
  • Name
    guanine nucleotide binding protein, alpha 11
  • Synonyms
    Dsk7
  • Feature Type
    protein coding gene
  • IDs
    MGI:95766
    NCBI Gene: 14672
  • Gene Overview
    MyGene.info: GNA11
Location & Maps
more
  • Sequence Map
    Chr10:81528724-81545190 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      16467 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    GNA11, G protein subunit alpha 11
  • Vertebrate Orthologs
    9
  • Human Ortholog
    GNA11, G protein subunit alpha 11
    Orthology source: HGNC, HomoloGene
  • Synonyms
    FBH, FBH2, FHH2, GNA-11, HHC2, HYPOC2
  • Links
    NCBI Gene ID: 2767
    neXtProt AC: NX_P29992

  • Chr Location
    19p13.3; chr19:3094410-3124002 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 20474
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: GNA11
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    23 phenotypes from 3 alleles in 5 genetic backgrounds
    71 phenotypes from multigenic genotypes
    53 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    11
  • Chemically induced (ENU)
    1
  • Chemically induced (other)
    1
  • Gene trapped
    6
  • Targeted
    3
  • Genomic Mutations
    1 involving Gna11
  • Incidental Mutations
Mice deficient for this gene do not exhibit any detectable abnormalities.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000030287 VEGA Gene Model | MGI Sequence Detail 16467 C57BL/6J ±  kb
transcript OTTMUST00000074975 VEGA | MGI Sequence Detail 3414 Not Applicable  
polypeptide OTTMUSP00000039227 VEGA | MGI Sequence Detail 359 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    44 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    4 Sequences
  • Protein Ontology
    PR:000008080 guanine nucleotide-binding protein subunit alpha-11
  • InterPro Domains
    IPR000654 G-protein alpha subunit, group Q
    IPR011025 G protein alpha subunit, helical insertion
    IPR001019 Guanine nucleotide binding protein (G-protein), alpha subunit
    IPR027417 P-loop containing nucleoside triphosphate hydrolase
Molecular
Reagents
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  • All nucleic 25
    Genomic 8
    cDNA 12
    Primer pair 4
    Other 1

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-10175, MGI:2450689
References
more
  • Summaries
    All 93
    Developmental Gene Expression 8
    Gene Ontology 13
    Phenotypes 53
  • Earliest
    J:30942 Sewell JL, et al., Sequences of the bovine and yeast ADP-ribosylation factor and comparison to other GTP-binding proteins. Proc Natl Acad Sci U S A. 1988 Jul;85(13):4620-4
  • Latest
    J:229824 Li YQ, et al., Gq/11alpha and Gsalpha mediate distinct physiological responses to central melanocortins. J Clin Invest. 2016 Jan 4;126(1):40-9

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory