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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Gna11
guanine nucleotide binding protein, alpha 11
MGI:95766
75 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background		 Annotated Term Reference
Cd19tm1(cre)Cgn/Cd19+
Gna11tm1Soff/Gna11tm1Soff
Gnaqtm2Soff/Gnaqtm2Soff
B6N.129-Cd19tm1(cre)Cgn Gna11tm1Soff Gnaqtm2Soff 		normal hematopoietic system phenotype J:117663
Gna11tm1Soff/Gna11+
Gnaqtm1Soff/Gnaq+
involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6 		no abnormal phenotype detected J:49140
Gna11tm1Soff/Gna11+
Gnaqtm1Soff/Gnaqtm1Soff
involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6 		abnormal breathing pattern J:49140
abnormal tympanic ring morphology J:49140
common ventricle J:49140
decreased body size J:49140
decreased pulmonary respiratory rate J:49140
hyporesponsive to tactile stimuli J:49140
hypoxia J:49140
incus hypoplasia J:49140
malleus hypoplasia J:49140
neonatal lethality, complete penetrance J:49140
short mandible J:49140
stapes hypoplasia J:49140
Gna11tm1Soff/Gna11+
Gnaqtm2Soff/Gnaqtm2Soff
Tg(PTH-cre)4167Slib/0
involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 		abnormal circulating calcium level J:116986
abnormal urine calcium level J:116986
decreased body weight J:116986
increased circulating parathyroid hormone level J:116986
Gna11tm1Soff/Gna11tm1Soff
Gnaqtm1Soff/Gnaq+
involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6 		abnormal breathing pattern J:49140
abnormal heart size J:49140
decreased body size J:49140
decreased pulmonary respiratory rate J:49140
hyporesponsive to tactile stimuli J:49140
hypoxia J:49140
neonatal lethality, complete penetrance J:49140
Gna11tm1Soff/Gna11tm1Soff
Gnaqtm1Soff/Gnaqtm1Soff
involves: 129S1/Sv * 129S7/SvEvBrd * C57BL/6 		embryonic lethality during organogenesis, complete penetrance J:49140
hemopericardium J:49140
trabecula carnea hypoplasia J:49140
ventricular myocardium compact layer hypoplasia J:49140
Gna11tm1Soff/Gna11tm1Soff
Gnaqtm2Soff/Gnaq+
Tg(PTH-cre)4167Slib/0
involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 		abnormal circulating calcium level J:116986
abnormal urine calcium level J:116986
decreased body weight J:116986
increased circulating parathyroid hormone level J:116986
Gna11tm1Soff/Gna11tm1Soff
Gnaqtm2Soff/Gnaqtm2Soff
Myl2tm1(cre)Krc/Myl2+
involves: 129P2/OlaHsd * 129S4/SvJae * 129S7/SvEvBrd * C57BL 		decreased response of heart to induced stress J:77461
heart hypoplasia J:77461
perinatal lethality, incomplete penetrance J:77461
Gna11tm1Soff/Gna11tm1Soff
Gnaqtm2Soff/Gnaqtm2Soff
Tg(Camk2a-cre)1Gsc/0
involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 * FVB/N 		abnormal nervous system electrophysiology J:123222
clonic seizures J:111559
gliosis J:111559
hippocampal neuron degeneration J:111559
premature death J:111559
seizures J:111559
tonic-clonic seizures J:111559
Gna11tm1Soff/Gna11tm1Soff
Gnaqtm2Soff/Gnaqtm2Soff
Tg(Mpz-cre)94Imeg/0
involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 		abnormal alisphenoid bone morphology J:131382
abnormal hyoid bone morphology J:131382
abnormal palatine bone morphology J:131382
abnormal pterygoid process morphology J:131382
abnormal sphenoid bone morphology J:131382
abnormal zygomatic bone morphology J:131382
normal craniofacial phenotype J:131382
lower jaw to upper jaw transformation J:131382
Gna11tm1Soff/Gna11tm1Soff
Gnaqtm2Soff/Gnaqtm2Soff
X/Tg(Myh11-icre/ERT2)1Soff
involves: 129P2/OlaHsd * 129S7/SvEvBrd * FVB/N 		decreased mean systemic arterial blood pressure J:141641
decreased systemic arterial blood pressure J:141641
decreased vasoconstriction J:141641
Gna11tm1Soff/Gna11tm1Soff
Gnaqtm2Soff/Gnaqtm2Soff
Tg(PTH-cre)4167Slib/0
involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 		abnormal bone mineralization J:116986
abnormal epiphyseal plate morphology J:116986
abnormal larynx morphology J:116986
abnormal parathyroid gland morphology J:116986
decreased body length J:116986
decreased body weight J:116986
decreased bone mineral density J:116986
delayed endochondral bone ossification J:116986
domed cranium J:116986
increased bone resorption J:116986
increased circulating parathyroid hormone level J:116986
increased urine calcium level J:116986
postnatal growth retardation J:116986
postnatal lethality J:116986
proportional dwarf J:116986
rachitic rosary J:116986
short snout J:116986
small thyroid gland J:116986
wide cranial sutures J:116986
Gna11tm1Soff/Gna11tm1Soff
Gnaqtm2Soff/Gnaqtm2Soff
Tg(Tek-icre/ERT2)1Soff/0
B6N.Cg-Gna11tm1Soff Gnaqtm2Soff Tg(Tek-icre/ERT2)1Soff 		abnormal vascular wound healing J:224523
decreased nitrate level J:224523
decreased vasodilation J:224523
increased susceptibility to hypertension J:224523
Gna11tm1Soff/Gna11tm1Soff
Gnaqtm2Soff/Gnaqtm2Soff
Tg(Tek-icre/ERT2)1Soff/?
involves: 129P2/OlaHsd * 129S7/SvEvBrd * FVB/N 		decreased susceptibility to type I hypersensitivity reaction J:146132
decreased vascular permeability J:146132
normal immune system phenotype J:146132
Gna11tm1Soff/Gna11tm1Soff
Gnaqtm2Soff/Gnaqtm2Soff
Tg(Tg-cre)1Soff/0
involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 		abnormal thyroid follicular cell morphology J:127484
abnormal thyroid gland morphology J:127484
abnormal thyroid gland physiology J:127484
decreased activity of thyroid gland J:127484
decreased circulating thyroxine level J:127484
normal endocrine/exocrine gland phenotype J:127484
increased circulating thyroid-stimulating hormone level J:127484
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04/09/2024
MGI 6.23 		The Jackson Laboratory