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Gli1
Gene Detail
 Symbol
Name
ID
Gli1
GLI-Kruppel family member GLI1
MGI:95727
Synonyms Zfp5, Zfp-5
Feature Type protein coding gene
Genetic Map
Chromosome 10
74.50 cM
Detailed Genetic Map ± 1 cM


Mapping data(24)
Sequence Map
Chr10:127329882-127341579 bp, - strand
From NCBI annotation of GRCm38

  11698 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3859  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Gene Tree: Gli1

Human
homologs
Human Homolog GLI1, GLI family zinc finger 1
NCBI Gene ID 2735
neXtProt AC  NX_P08151
Human Synonyms  GLI
Human Chr (Location)  12q13.2-q13.3; chr12:57460135-57472268 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(14) : Gene trapped(9) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for a targeted null mutation are apparently normal, but homozygotes that are also heterozygous for a Gli2 knockout die soon after birth with multiple defects, while Gli2 knockout heterozygotes are normally viable.
 
Interactions
Gli1 interacts with 52 markers (Mir24-1, Mir24-2, Mir188, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (49 annotations)
Process cell differentiation, cerebellar cortex morphogenesis, ...
Component cilium, cytoplasm, ...
Function chromatin binding, DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (438 records)
Data Summary: Results (899)    Tissues (415)    Images (270)
Theiler Stages: 2, 3, 7, 9, 11, 12, 13, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28
Assay TypeResults
RNA in situ 746
In situ reporter (knock in) 24
Northern blot 39
Western blot 1
RT-PCR 89
cDNA source data(24)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(65) Genomic(2) cDNA(28) Primer pair(12) Other(23)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000025407 (Evidence)
Entrez Gene14632 (Evidence)
NIA Mouse Gene IndexU032336
Consensus CDS ProjectCCDS24238.1
International Mouse Knockout Project StatusGli1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 14632 NCBI Gene Model | MGI Sequence Detail 11698 C57BL/6J ±  kb
transcript NM_010296 RefSeq | MGI Sequence Detail 3662 C57BL/6 
polypeptide P47806 UniProt | EBI | MGI Sequence Detail 1111 Not Applicable 

For the selected sequences
All sequences(27) RefSeq(2) UniProt(5)
Polymorphisms RFLP(3) : SNPs within 2kb(83 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR007087 Zinc finger, C2H2
InterPro IPR015880 Zinc finger, C2H2-like
InterPro IPR013087 Zinc finger C2H2-type/integrase DNA-binding domain
Protein Ontology PR:000008026 zinc finger protein GLI1
Graphical View of Protein Domain Structure
References (Earliest) J:5123 Johnson DR, Brachyphalangy, an allele of extra-toes in the mouse. Genet Res. 1969 Jun;13(3):275-80
(Latest) J:210170 Zhao H, et al., Secretion of shh by a neurovascular bundle niche supports mesenchymal stem cell homeostasis in the adult mouse incisor. Cell Stem Cell. 2014 Feb 6;14(2):160-73
All references(575)
Other
accession IDs
MGD-MRK-10105, MGD-MRK-15893, MGD-MRK-15948, MGI:2143787, MGI:99196

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory