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Gli1 Gene Detail
Summary
  • Symbol
    Gli1
  • Name
    GLI-Kruppel family member GLI1
  • Synonyms
    Zfp-5, Zfp5
  • Feature Type
    protein coding gene
  • IDs
    MGI:95727
    NCBI Gene: 14632
  • Alliance
    genome feature page
  • Transcription Start Sites
    5 TSS
  • Regulated by
    Rr216 (1 regulatory region)
Location &
Maps
more
  • Sequence Map
    Chr10:127165751-127177448 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 74.50 cM
  • Mapping Data
    24 experiments
Strain
Comparison
more
  • SNPs within 2kb
    361 from dbSNP Build 142
  • Strain Annotations
    19
  • RFLP
    3
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95727
 protein coding gene Chr10:127165751-127177843 (-)
129S1/SvImJ ENSMUSG00200009483
 protein coding gene Chr10:123518727-123530820 (-)
A/J ENSMUSG00195016356
 protein coding gene Chr10:123982784-123994879 (-)
AKR/J ENSMUSG00220004887
 protein coding gene Chr10:123587343-123599439 (-)
BALB/cJ ENSMUSG00180011207
 protein coding gene Chr10:123973848-123985946 (-)
C3H/HeJ ENSMUSG00175005666
 protein coding gene Chr10:123972480-123984962 (-)
C57BL/6NJ ENSMUSG00215015385
 protein coding gene Chr10:123583936-123596030 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015893
 protein coding gene Chr10:119682022-119693822 (-)
CAST/EiJ ENSTCUG00005041192
 protein coding gene Chr10:122951760-122963906 (-)
CBA/J ENSMUSG00210008018
 protein coding gene Chr10:123796671-123809154 (-)
DBA/2J ENSMUSG00185024216
 protein coding gene Chr10:123948868-123960964 (-)
FVB/NJ ENSMUSG00205011514
 protein coding gene Chr10:123193410-123205504 (-)
JF1/MsJ ENSUMUG00000033578
 protein coding gene Chr10:125244253-125256329 (-)
LP/J ENSMUSG00230027915
 protein coding gene Chr10:125866050-125878127 (-)
NOD/ShiLtJ ENSMUSG00190015143
 protein coding gene Chr10:124015841-124027935 (-)
NZO/HlLtJ ENSMUSG00225035909
 protein coding gene Chr10:130066604-130078697 (-)
PWK/PhJ ENSLUMG00010008675
 protein coding gene Chr10:123704423-123716498 (-)
SPRET/EiJ ENSMSPG00010034608
 protein coding gene Chr10:125654544-125666680 (-)
WSB/EiJ ENSIUOG00005006865
 protein coding gene Chr10:123583158-123595240 (-)



Homology
more
  • Human Ortholog
    GLI1, GLI family zinc finger 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GLI1, GLI family zinc finger 1
  • Synonyms
    GLI, PAPA8, PPD1
  • Links
    NCBI Gene ID: 2735
    UniProt: P08151

  • Chr Location
    12q13.3; chr12:57459785-57472268 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with human GLI1 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 2 alleles in 2 genetic backgrounds
    54 phenotypes from multigenic genotypes
    477 phenotype references
Homozygotes for a targeted null mutation are apparently normal, but homozygotes that are also heterozygous for a Gli2 knockout die soon after birth with multiple defects, while Gli2 knockout heterozygotes are normally viable.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    112
  • GO References
    34
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    2381
  • Tissues
    666
  • cDNA Data
    26
  • Literature Summary
    841
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 14632 NCBI Gene Model | MGI Sequence Detail 11698 C57BL/6J ±  kb
transcript NM_010296 RefSeq | MGI Sequence Detail 3662 C57BL/6  
polypeptide P47806 UniProt | EBI | MGI Sequence Detail 1111 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 186
    Genomic 2
    cDNA 33
    Primer pair 60
    Other 91
    Antibodies 7

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-10105, MGD-MRK-15893, MGD-MRK-15948, MGI:2143787, MGI:99196
References
more
  • Summaries
    All 1424
    Developmental Gene Expression 841
    Gene Ontology 34
    Phenotypes 477
  • Earliest
    J:5123 Johnson DR, Brachyphalangy, an allele of extra-toes in the mouse. Genet Res. 1969 Jun;13(3):275-80
  • Latest
    J:391812 Correia Cavalcante R, et al., Gli1(+) Cells Exhibit Clonogenicity and Slow-Cycling Features at the Temporomandibular Joint (TMJ) Enthesis-Condyle Interface. Int J Mol Sci. 2026 Apr 7;27(7)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/01/2026
MGI 6.24 		The Jackson Laboratory