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Gli1
Gene Detail
Symbol

Name
ID
Gli1
GLI-Kruppel family member GLI1
MGI:95727
Synonyms
Zfp5, Zfp-5
Feature Type
protein coding gene
Genetic Map
Chromosome 10
74.50 cM
Detailed Genetic Map ± 1 cM


Mapping data(24)
Sequence Map
Chr10:127329881-127341579 bp, - strand
From NCBI annotation of GRCm38

  11699 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3859  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

HCOP human homology predictions: GLI1
Gene Tree: Gli1

Human
homologs
GLI1, GLI family zinc finger 1
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 2735
neXtProt AC: NX_P08151

Human Synonyms: GLI

Human Chr (Location): 12q13.2-q13.3; chr12:57460135-57472268 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(16) : Gene trapped(9) Targeted(6) Transgenic(1)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for a targeted null mutation are apparently normal, but homozygotes that are also heterozygous for a Gli2 knockout die soon after birth with multiple defects, while Gli2 knockout heterozygotes are normally viable.
 
Interactions
Gli1 interacts with 52 markers (Mir24-1, Mir24-2, Mir188, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (49 annotations)
Process cell differentiation, cerebellar cortex morphogenesis, ...
Component cilium, cytoplasm, ...
Function chromatin binding, DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (473 records)
Data Summary: Results (907)    Tissues (415)    Images (277)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 754
In situ reporter (knock in) 24
Northern blot 39
Western blot 1
RT-PCR 89
cDNA source data(24)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: GEISHA GLI1 ; Xenbase gli1 ; ZFIN gli1    NEW 
Molecular
reagents
All nucleic(67) Genomic(2) cDNA(28) Primer pair(12) Other(25)
Microarray probesets(4)
Other database
links
Ensembl Gene Model ENSMUSG00000025407 (Evidence)
Entrez Gene 14632 (Evidence)
NIA Mouse Gene Index U032336
Consensus CDS Project CCDS24238.1
International Mouse Phenotyping Consortium Status Gli1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 14632 NCBI Gene Model | MGI Sequence Detail 11699 C57BL/6J ±  kb
transcript NM_010296 RefSeq | MGI Sequence Detail 3662 C57BL/6 
polypeptide P47806 UniProt | EBI | MGI Sequence Detail 1111 Not Applicable 

For the selected sequences
All sequences(30) RefSeq(4) UniProt(5)
Polymorphisms
RFLP(3) : SNPs within 2kb(83 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR007087 Zinc finger, C2H2
InterPro IPR015880 Zinc finger, C2H2-like
InterPro IPR013087 Zinc finger C2H2-type/integrase DNA-binding domain
Protein Ontology PR:000008026 zinc finger protein GLI1
Graphical View of Protein Domain Structure
References
(Earliest) J:5123 Johnson DR, Brachyphalangy, an allele of extra-toes in the mouse. Genet Res. 1969 Jun;13(3):275-80
(Latest) J:220963 Nosavanh L, et al., Cell-autonomous activation of Hedgehog signaling inhibits brown adipose tissue development. Proc Natl Acad Sci U S A. 2015 Apr 21;112(16):5069-74
All references(614)
Other
accession IDs
MGD-MRK-10105, MGD-MRK-15893, MGD-MRK-15948, MGI:2143787, MGI:99196

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory