Automated description from the Alliance of Genome Resources (Release 7.0.0)
Enables several functions, including DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and microtubule binding activity. Involved in positive regulation of DNA-templated transcription and regulation of osteoblast differentiation. Acts upstream of or within several processes, including central nervous system development; liver regeneration; and regionalization. Located in axoneme and nucleus. Is expressed in several structures, including alimentary system; central nervous system; embryo mesenchyme; long bone; and sensory organ. Human ortholog(s) of this gene implicated in gallbladder cancer. Orthologous to human GLI1 (GLI family zinc finger 1).