Sequence Detail

ID/Version

P47806 Q9QYK1 G5E857 (UniProt | EBI)

Last sequence update: 2012-10-03
Last annotation update: 2026-06-10

Sequence description from provider

RecName: Full=Transcription activator GLI1;AltName: Full=Glioma-associated oncogene homolog;

Provider

SWISS-PROT

Sequence

Polypeptide 1111 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Gli1	GLI-Kruppel family member GLI1	112	373	3	22

Sequence references in MGI

J:12857 Walterhouse D, et al., gli, a zinc finger transcription factor and oncogene, is expressed during normal mouse development. Dev Dyn. 1993 Feb;196(2):91-102
J:46858 Liu CZ, et al., Characterization of the promoter region and genomic organization of GLI, a member of the Sonic hedgehog-Patched signaling pathway. Gene. 1998 Mar 16;209(1-2):1-11
J:56563 Sasaki H, et al., Regulation of Gli2 and Gli3 activities by an amino-terminal repression domain: implication of Gli2 and Gli3 as primary mediators of Shh signaling. Development. 1999 Sep;126(17):3915-24
J:60986 Park HL, et al., Mouse Gli1 mutants are viable but have defects in SHH signaling in combination with a Gli2 mutation. Development. 2000 Apr;127(8):1593-605
J:73074 Bai CB, et al., Gli1 can rescue the in vivo function of Gli2. Development. 2001 Dec;128(24):5161-72
J:121411 Vokes SA, et al., Genomic characterization of Gli-activator targets in sonic hedgehog-mediated neural patterning. Development. 2007 May;134(10):1977-89
J:152551 Endoh-Yamagami S, et al., The mammalian Cos2 homolog Kif7 plays an essential role in modulating Hh signal transduction during development. Curr Biol. 2009 Aug 11;19(15):1320-6
J:165480 Tukachinsky H, et al., A mechanism for vertebrate Hedgehog signaling: recruitment to cilia and dissociation of SuFu-Gli protein complexes. J Cell Biol. 2010 Oct 18;191(2):415-28
J:381436 Cai Q, et al., Protein kinase Cdelta negatively regulates hedgehog signaling by inhibition of Gli1 activity. J Biol Chem. 2009 Jan 23;284(4):2150-8