Ghrh
Gene Detail

Symbol Name ID

Ghrh growth hormone releasing hormone MGI:95709

Synonyms

Ghrf

Feature Type

protein coding gene

Genetic Map

Chromosome 2

78.25 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)

Sequence Map

Chr2:157329497-157347506 bp, - strand From VEGA annotation of GRCm38   18010 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:7731  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog

Protein SuperFamily: glucagon
Gene Tree: Ghrh

Human homologs

Human Homolog		GHRH, growth hormone releasing hormone
NCBI Gene ID		2691
neXtProt AC		NX_P01286
Human Synonyms		GHRF, GRF, INN
Human Chr (Location)		20q11.2; chr20:35879489-35885299 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(9) : Targeted(3) Gene trapped(6)
 

Mice homozygoous for a knock-out allele exhibit postnatal growth retardation, decreased body weight and body length, reduced IGF-I production and serum IGF-I levels, pituitary hypoplasia, decreased growth hormone level, and decreased litter size.

 
Human Diseases Modeled Using Mouse Ghrh (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (44 annotations)

Process	adenohypophysis development, adenylate cyclase-activating G-protein coupled receptor signaling pathway, ...
Component	axon terminus, extracellular region, ...
Function	growth hormone-releasing hormone activity, growth hormone-releasing hormone receptor binding, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (10 records)
Data Summary: Results (186)    Tissues (139)    Images (7)
Theiler Stages: 22, 23, 28

Assay Type	Results
RNA in situ	94
RT-PCR	92

cDNA source data(10)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(13) cDNA(11) Primer pair(2)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000016171 (Evidence)
Ensembl Gene Model	ENSMUSG00000027643 (Evidence)
Entrez Gene	14601 (Evidence)
UniGene	389327
DFCI	TC1588465, TC1595532, TC1741515
DoTS	DT.60106942, DT.91448002, DT.91448003
NIA Mouse Gene Index	U023578
Consensus CDS Project	CCDS16976.1
International Mouse Knockout Project Status	Ghrh

Sequences

Length	Strain/Species
genomic	OTTMUSG00000016171	VEGA Gene Model | MGI Sequence Detail	18010	C57BL/6J
transcript	OTTMUST00000038699	VEGA | MGI Sequence Detail	516	Not Applicable
polypeptide	OTTMUSP00000017306	VEGA | MGI Sequence Detail	103	Not Applicable

All sequences(31) RefSeq(2) UniProt(2)

Polymorphisms

SNPs(137 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000532	Glucagon/GIP/secretin/VIP
Protein Ontology	PR:000007971	somatoliberin

References

(Earliest) J:47391 Mitrakou A, et al., Heterogeneity of growth-hormone deficiency [letter]. Lancet. 1985 Feb 16;1(8425):399-400
(Latest) J:190524 Shalom-Barak T, et al., Placental PPARgamma regulates spatiotemporally diverse genes and a unique metabolic network. Dev Biol. 2012 Dec 1;372(1):143-55
All references(94)

Other accession IDs

MGD-MRK-10071, MGD-MRK-10073