About   Help   FAQ
Ghrh
Gene Detail
Symbol

Name
ID
Ghrh
growth hormone releasing hormone
MGI:95709
Synonyms
Ghrf
Feature Type
protein coding gene
Genetic Map
Chromosome 2
78.25 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr2:157329497-157347506 bp, - strand
From VEGA annotation of GRCm38

  18010 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7731  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

Protein SuperFamily: glucagon
Gene Tree: Ghrh

Human
homologs
Human Homolog GHRH, growth hormone releasing hormone
NCBI Gene ID 2691
neXtProt AC  NX_P01286
Human Synonyms  GHRF, GRF, INN
Human Chr (Location)  20q11.2; chr20:37251086-37256896 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(9) : Gene trapped(6) Targeted(3)
Incidental mutations (data from APF )
 
Mice homozygoous for a knock-out allele exhibit postnatal growth retardation, decreased body weight and body length, reduced IGF-I production and serum IGF-I levels, pituitary hypoplasia, decreased growth hormone level, and decreased litter size.
 
Human Diseases Modeled Using Mouse Ghrh (1)    Alleles Annotated to Human Diseases(1)   
Interactions
Ghrh interacts with 15 markers (Mir23a, Mir137, Mir184, ...)
Expression
Literature Summary: (11 records)
Data Summary: Results (186)    Tissues (139)    Images (7)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 94
RT-PCR 92
cDNA source data(10)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(13) cDNA(11) Primer pair(2)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000016171 (Evidence)
Ensembl Gene ModelENSMUSG00000027643 (Evidence)
Entrez Gene14601 (Evidence)
UniGene389327
DFCITC1588465, TC1595532, TC1741515
DoTSDT.60106942, DT.91448002, DT.91448003
NIA Mouse Gene IndexU023578
Consensus CDS ProjectCCDS16976.1
International Mouse Knockout Project StatusGhrh
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016171 VEGA Gene Model | MGI Sequence Detail 18010 C57BL/6J ±  kb
transcript OTTMUST00000038700 VEGA | MGI Sequence Detail 503 Not Applicable 
polypeptide OTTMUSP00000017307 VEGA | MGI Sequence Detail 103 Not Applicable 

For the selected sequences
All sequences(36) RefSeq(6) UniProt(3)
Polymorphisms
SNPs within 2kb(292 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000532 Glucagon/GIP/secretin/VIP
Protein Ontology PR:000007971 somatoliberin
References
(Earliest) J:47391 Mitrakou A, et al., Heterogeneity of growth-hormone deficiency [letter]. Lancet. 1985 Feb 16;1(8425):399-400
(Latest) J:207782 Sun LY, et al., Growth hormone-releasing hormone disruption extends lifespan and regulates response to caloric restriction in mice. Elife. 2013;2:e01098
All references(96)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-10071, MGD-MRK-10073

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
11/18/2014
MGI 5.20
The Jackson Laboratory