About   Help   FAQ
Ghrh
Gene Detail
Symbol

Name
ID
Ghrh
growth hormone releasing hormone
MGI:95709
Synonyms
Ghrf
Feature Type
protein coding gene
Genetic Map
Chromosome 2
78.25 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr2:157329497-157347506 bp, - strand
From VEGA annotation of GRCm38

  18010 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7731  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

HCOP human homology predictions: GHRH
Protein SuperFamily: glucagon
Gene Tree: Ghrh

Human
homologs
GHRH, growth hormone releasing hormone
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 2691
neXtProt AC: NX_P01286

Human Synonyms: GHRF, GRF, INN

Human Chr (Location): 20q11.2; chr20:37251065-37261878 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Gene trapped(6) Targeted(4)
Incidental mutations (data from APF )
 
Mice homozygoous for a knock-out allele exhibit postnatal growth retardation, decreased body weight and body length, reduced IGF-I production and serum IGF-I levels, pituitary hypoplasia, decreased growth hormone level, and decreased litter size.
 
Human Diseases Modeled in Mice Using Ghrh (1)    Mutations Annotated to Human Diseases (1)   
Interactions
Ghrh interacts with 15 markers (Mir23a, Mir137, Mir184, ...)
Expression
Literature Summary: (13 records)
Data Summary: Results (191)    Tissues (142)    Images (7)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 99
RT-PCR 92
cDNA source data(10)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase LOC100492713 ; ZFIN ghrh    NEW 
Molecular
reagents
All nucleic(14) cDNA(11) Primer pair(2) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000016171 (Evidence)
Ensembl Gene Model ENSMUSG00000027643 (Evidence)
Entrez Gene 14601 (Evidence)
UniGene 389327
DFCI TC1588465, TC1595532, TC1741515
DoTS DT.60106942, DT.91448002, DT.91448003
NIA Mouse Gene Index U023578
Consensus CDS Project CCDS16976.1
International Mouse Phenotyping Consortium Status Ghrh
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000016171 VEGA Gene Model | MGI Sequence Detail 18010 C57BL/6J ±  kb
transcript OTTMUST00000038700 VEGA | MGI Sequence Detail 503 Not Applicable 
polypeptide OTTMUSP00000017307 VEGA | MGI Sequence Detail 103 Not Applicable 

For the selected sequences
All sequences(35) RefSeq(6) UniProt(2)
Polymorphisms
SNPs within 2kb(292 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000532 Glucagon/GIP/secretin/VIP
Protein Ontology PR:000007971 somatoliberin
References
(Earliest) J:47391 Mitrakou A, et al., Heterogeneity of growth-hormone deficiency [letter]. Lancet. 1985 Feb 16;1(8425):399-400
(Latest) J:218838 Salvatierra J, et al., The LIM homeodomain factor Lhx2 is required for hypothalamic tanycyte specification and differentiation. J Neurosci. 2014 Dec 10;34(50):16809-20
All references(98)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-10071, MGD-MRK-10073

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
06/30/2015
MGI 5.22
The Jackson Laboratory