Gdf3
Gene Detail

Symbol Name ID

Gdf3 growth differentiation factor 3 MGI:95686

Synonyms

ecat9, Gdf-3, Vgr2, Vgr-2

Feature Type

protein coding gene

Genetic Map

Chromosome 6

57.70 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)

Sequence Map

Chr6:122605403-122610087 bp, - strand From VEGA annotation of GRCm38   4685 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:7336  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: bone morphogenetic protein
Gene Tree: Gdf3

Human homologs

Human Homolog		GDF3, growth differentiation factor 3
NCBI Gene ID		9573
neXtProt AC		NX_Q9NR23
Human Synonyms		KFS3, MCOP7, MCOPCB6
Human Chr (Location)		12p13.1; chr12:7842381-7848360 (-)  GRCh37.p10
Disease Associations		(3) Diseases Associated with Human GDF3

Alleles and phenotypes

All alleles(44) : Targeted(4) Gene trapped(40)
 

Mice homozygous for a null allele exhibit prenatal lethality and resistance to diet-induced obesity.

 

Gene Ontology (GO) classifications

All GO classifications: (23 annotations)

Process	endoderm development, eye development, ...
Component	extracellular region, extracellular space
Function	cytokine activity, growth factor activity, ...

External Resources: FuncBase

Expression

Literature Summary: (12 records)
Data Summary: Results (75)    Tissues (32)    Images (4)
Theiler Stages: 2, 3, 6, 19, 23, 25, 28

Assay Type	Results
RNA in situ	25
Northern blot	12
RT-PCR	38

cDNA source data(22)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(26) Genomic(1) cDNA(22) Primer pair(2) Other(1)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000021509 (Evidence)
Ensembl Gene Model	ENSMUSG00000030117 (Evidence)
Entrez Gene	14562 (Evidence)
UniGene	299742
DFCI	TC1584261
DoTS	DT.488172
NIA Mouse Gene Index	U027826
Consensus CDS Project	CCDS20499.1
International Mouse Knockout Project Status	Gdf3

Sequences

Length	Strain/Species
genomic	OTTMUSG00000021509	VEGA Gene Model | MGI Sequence Detail	4685	C57BL/6J
transcript	OTTMUST00000050988	VEGA | MGI Sequence Detail	2125	Not Applicable
polypeptide	OTTMUSP00000023934	VEGA | MGI Sequence Detail	366	Not Applicable

All sequences(29) RefSeq(2) UniProt(2)

Polymorphisms

RFLP(1) : SNPs within 2kb(17 from dbSNP Build 137)

Protein-related information

Resource	ID	Description
InterPro	IPR002405	Inhibin, alpha subunit
InterPro	IPR017948	Transforming growth factor beta, conserved site
InterPro	IPR001839	Transforming growth factor-beta, C-terminal
InterPro	IPR001111	Transforming growth factor-beta, N-terminal
InterPro	IPR015615	Transforming growth factor-beta-related
Protein Ontology	PR:000007922	growth/differentiation factor 3

References

(Earliest) J:3327 Jones CM, et al., Isolation of Vgr-2, a novel member of the transforming growth factor-beta-related gene family. Mol Endocrinol. 1992 Nov;6(11):1961-8
(Latest) J:184521 Koss M, et al., Congenital Asplenia in Mice and Humans with Mutations in a Pbx/Nkx2-5/p15 Module. Dev Cell. 2012 May 15;22(5):913-26
All references(54)

Other accession IDs

MGD-MRK-10034, MGD-MRK-10039, MGD-MRK-15389, MGD-MRK-15391, MGI:2141745