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Gdf3
Gene Detail
Symbol

Name
ID
Gdf3
growth differentiation factor 3
MGI:95686
Synonyms
ecat9, Gdf-3, Vgr2, Vgr-2
Feature Type
protein coding gene
Genetic Map
Chromosome 6
57.70 cM
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr6:122605403-122610087 bp, - strand
From VEGA annotation of GRCm38

  4685 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7336  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 western clawed frog; 1 zebrafish

HCOP human homology predictions: GDF3
Protein SuperFamily: bone morphogenetic protein
Gene Tree: Gdf3

Human
homologs
GDF3, growth differentiation factor 3
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 9573
neXtProt AC: NX_Q9NR23

Human Synonyms: KFS3, MCOP7, MCOPCB6

Human Chr (Location): 12p13.1; chr12:7689785-7695764 (-)  GRCh38.p2

Disease Associations: (3) Diseases Associated with Human GDF3

Mutations,
alleles, and
phenotypes
All mutations/alleles(44) : Gene trapped(40) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null allele exhibit prenatal lethality and resistance to diet-induced obesity.
 
Interactions
Gdf3 interacts with 133 markers (Mir7-2, Mir7b, Mir9-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (36 annotations)
Process BMP signaling pathway, cell development, ...
Component cytoplasm, extracellular region, ...
Function cytokine activity, growth factor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (14 records)
Data Summary: Results (75)    Tissues (32)    Images (4)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 25
Northern blot 12
RT-PCR 38
cDNA source data(22)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA GDF3 ; Xenbase gdf3 ; ZFIN gdf3    NEW 
Molecular
reagents
All nucleic(26) Genomic(1) cDNA(22) Primer pair(2) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000021509 (Evidence)
Ensembl Gene Model ENSMUSG00000030117 (Evidence)
Entrez Gene 14562 (Evidence)
UniGene 299742
DFCI TC1584261
DoTS DT.488172
NIA Mouse Gene Index U027826
Consensus CDS Project CCDS20499.1
International Mouse Phenotyping Consortium Status Gdf3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021509 VEGA Gene Model | MGI Sequence Detail 4685 C57BL/6J ±  kb
transcript OTTMUST00000050988 VEGA | MGI Sequence Detail 2125 Not Applicable 
polypeptide OTTMUSP00000023934 VEGA | MGI Sequence Detail 366 Not Applicable 

For the selected sequences
All sequences(31) RefSeq(4) UniProt(2)
Polymorphisms
RFLP(1) : SNPs within 2kb(17 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR029034 Cystine-knot cytokine
InterPro IPR002405 Inhibin, alpha subunit
InterPro IPR017948 Transforming growth factor beta, conserved site
InterPro IPR001839 Transforming growth factor-beta, C-terminal
InterPro IPR001111 Transforming growth factor-beta, N-terminal
InterPro IPR015615 Transforming growth factor-beta-related
Protein Ontology PR:000007922 growth/differentiation factor 3
References
(Earliest) J:3327 Jones CM, et al., Isolation of Vgr-2, a novel member of the transforming growth factor-beta-related gene family. Mol Endocrinol. 1992 Nov;6(11):1961-8
(Latest) J:219394 Boroviak T, et al., The ability of inner-cell-mass cells to self-renew as embryonic stem cells is acquired following epiblast specification. Nat Cell Biol. 2014 Jun;16(6):516-28
All references(56)
Other
accession IDs
MGD-MRK-10034, MGD-MRK-10039, MGD-MRK-15389, MGD-MRK-15391, MGI:2141745

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory