Gdf3 Phenotype Annotations

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Gdf3
growth differentiation factor 3
MGI:95686

26 phenotypes from 3 alleles in 3 genetic backgrounds

Allelic Composition Genetic Background	Annotated Term	Reference
Gdf3^{Gt(AD0857)Wtsi}/Gdf3^{Gt(AD0857)Wtsi} involves: 129P2/OlaHsd * C57BL/6	abnormal anterior visceral endoderm cell migration	J:127541
	abnormal primitive streak elongation	J:127541
	abnormal primitive streak formation	J:127541
	absent anterior visceral endoderm	J:127541
	absent mesoderm	J:127541
	decreased survivor rate	J:127541
	embryonic lethality between implantation and somite formation, incomplete penetrance	J:127541
	rostral body truncation	J:127541
Gdf3^tm1Mms/Gdf3^tm1Mms either: B6.129-Gdf3^tm1Mms or (involves: 129S7/SvEvBrd * C57BL/6J)	abnormal anterior visceral endoderm cell migration	J:104371
	abnormal anterior visceral endoderm morphology	J:104371
	abnormal developmental patterning	J:104371
	abnormal endoderm development	J:104371
	abnormal mesoderm development	J:104371
	abnormal primitive streak formation	J:104371
	abnormal rostral-caudal axis patterning	J:104371
	absent endoderm	J:104371
	embryonic lethality, complete penetrance	J:104371
	embryonic-extraembryonic boundary constriction	J:104371
	rostral-caudal axis duplication	J:104371
	split notochord	J:104371
	thin endoderm	J:104371
Gdf3^tm1Zuk/Gdf3^tm1Zuk involves: 129S7/SvEvBrd * C57BL/6J	abnormal fat cell morphology	J:143083
	decreased survivor rate	J:143083
	decreased susceptibility to diet-induced obesity	J:143083
	decreased white adipose tissue amount	J:143083
	normal growth/size/body region phenotype	J:143083
	improved glucose tolerance	J:143083
	increased basal metabolism	J:143083
	prenatal lethality, incomplete penetrance	J:143083

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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