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Slc6a1
Gene Detail
Symbol

Name
ID
Slc6a1
solute carrier family 6 (neurotransmitter transporter, GABA), member 1
MGI:95627
Synonyms
Gabt, Gabt1, Gat1, GAT-1, XT-1, Xtrp1
Feature Type
protein coding gene
Genetic Map
Chromosome 6
53.05 cM, cytoband E3
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr6:114282635-114317522 bp, + strand
From Ensembl annotation of GRCm38

  34888 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2290  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

Gene Tree: Slc6a1

Human
homologs
Human Homolog SLC6A1, solute carrier family 6 (neurotransmitter transporter), member 1
NCBI Gene ID 6529
neXtProt AC  NX_P30531
Human Synonyms  GABATHG, GABATR, GAT1
Human Chr (Location)  3p25.3; chr3:10992734-11039249 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Gene trapped(2) Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous hypomorphic mice display abnormal inhibitory postsynaptic currents, and abnormal GABA uptake and release. Null mice show hyperactivity and various behavioral abnormalities, as well as an aversion to bitter taste.
 
Human Diseases Modeled Using Mouse Slc6a1 (1)    Alleles Annotated to Human Diseases(1)   
Interactions
Slc6a1 interacts with 323 markers (Mir1b, Mir10a, Mir15a, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (20 records)
Data Summary: Results (456)    Tissues (198)    Images (65)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 8
RNA in situ 355
RT-PCR 93
cDNA source data(71)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(84) Genomic(2) cDNA(75) Primer pair(6) Other(1)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000030310 (Evidence)
Entrez Gene232333 (Evidence)
UniGene5260
DFCITC1575900
DoTSDT.101391027, DT.101737105
NIA Mouse Gene IndexU007286
Consensus CDS ProjectCCDS20434.1
International Mouse Knockout Project StatusSlc6a1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000030310 Ensembl Gene Model | MGI Sequence Detail 34888 C57BL/6J ±  kb
transcript ENSMUST00000032454 Ensembl | MGI Sequence Detail 4292 Not Applicable 
polypeptide ENSMUSP00000032454 Ensembl | MGI Sequence Detail 599 Not Applicable 

For the selected sequences
All sequences(24) RefSeq(2) UniProt(3)
Polymorphisms
RFLP(1) : SNPs within 2kb(469 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000175 Sodium:neurotransmitter symporter
InterPro IPR002980 Sodium:neurotransmitter symporter, GABA, GAT-1
Protein Ontology PR:000015176 sodium- and chloride-dependent GABA transporter 1
References
(Earliest) J:1492 Liu QR, et al., A family of genes encoding neurotransmitter transporters. Proc Natl Acad Sci U S A. 1992 Jul 15;89(14):6639-43
(Latest) J:209100 Xu XH, et al., Essential roles of GABA transporter-1 in controlling rapid eye movement sleep and in increased slow wave activity after sleep deprivation. PLoS One. 2013;8(10):e75823
All references(74)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-19419, MGD-MRK-9946, MGD-MRK-9947

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/18/2014
MGI 5.20
The Jackson Laboratory