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Fyn
Gene Detail
 Symbol
Name
ID
Fyn
Fyn proto-oncogene
MGI:95602
Synonyms Src Kinase p59
Feature Type protein coding gene
Genetic Map
Chromosome 10
20.51 cM
Detailed Genetic Map ± 1 cM


Mapping data(16)
Sequence Map
Chr10:39368855-39565381 bp, + strand
From VEGA annotation of GRCm38

  196527 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:48068  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: tyrosine-protein kinase, proto-oncogene SRC type
Gene Tree: Fyn

Human
homologs
Human Homolog FYN, FYN proto-oncogene, Src family tyrosine kinase
NCBI Gene ID 2534
neXtProt AC  NX_P06241
Human Synonyms  p59-FYN, SLK, SYN
Human Chr (Location)  6q21; chr6:111660332-111873452 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(13) : Gene trapped(7) Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Different targeted allele homozygotes show different defects, including seizure susceptibility, anxiety, impaired suckling, myelination, LTP and spatial learning, and defects in immune system, circadian rhythm, testes weight and olfactory bulb formation.
 
Interactions
Fyn interacts with 304 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (85 annotations)
Process activated T cell proliferation, cell surface receptor signaling pathway, ...
Component cytoplasm, endosome, ...
Function ATP binding, CD4 receptor binding, ...
External Resources: FuncBase
Expression
Literature Summary: (32 records)
Data Summary: Results (203)    Tissues (181)    Images (25)
Theiler Stages: 11, 13, 15, 17, 19, 20, 21, 22, 23, 24, 25, 26, 28
Assay TypeResults
Immunohistochemistry 4
RNA in situ 130
In situ reporter (knock in) 42
Northern blot 25
Western blot 2
cDNA source data(22)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(32) Genomic(3) cDNA(27) Primer pair(1) Other(1)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000034130 (Evidence)
Ensembl Gene ModelENSMUSG00000019843 (Evidence)
Entrez Gene14360 (Evidence)
DFCITC1575770, TC1588628, TC1603454, TC1627441, TC1633770
DoTSDT.101277672, DT.101725436, DT.534255, DT.94309707, DT.99840621
NIA Mouse Gene IndexU011411
EC2.7.10.2
PDB3UF4
Consensus CDS ProjectCCDS23788.1, CCDS48538.1
International Mouse Knockout Project StatusFyn
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000034130 VEGA Gene Model | MGI Sequence Detail 196527 C57BL/6J ±  kb
transcript OTTMUST00000086387 VEGA | MGI Sequence Detail 3528 Not Applicable 
polypeptide OTTMUSP00000046778 VEGA | MGI Sequence Detail 537 Not Applicable 

For the selected sequences
All sequences(90) RefSeq(14) UniProt(4)
Polymorphisms RFLP(3) : SNPs within 2kb(1402 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
InterPro IPR000980 SH2 domain
InterPro IPR001452 Src homology-3 domain
InterPro IPR008266 Tyrosine-protein kinase, active site
InterPro IPR020635 Tyrosine-protein kinase, catalytic domain
Protein Ontology PR:000003003 tyrosine-protein kinase Fyn
References (Earliest) J:31022 Kawakami T, et al., Isolation and oncogenic potential of a novel human src-like gene. Mol Cell Biol. 1986 Dec;6(12):4195-201
(Latest) J:211668 Cordero JB, et al., c-Src drives intestinal regeneration and transformation. EMBO J. 2014 Jul 1;33(13):1474-91
All references(343)
Other
accession IDs
MGD-MRK-9909, MGI:2143602, MGI:2143864

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory