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Fyn Gene Detail
Summary
  • Symbol
    Fyn
  • Name
    Fyn proto-oncogene
  • Synonyms
    Src Kinase p59
  • Feature Type
    protein coding gene
  • IDs
    MGI:95602
    NCBI Gene: 14360
  • Gene Overview
    MyGene.info: FYN
Location & Maps
more
  • Sequence Map
    Chr10:39368855-39565381 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      196527 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 20.51 cM
  • Mapping Data
    16 experiments
Homology
more
  • Human Ortholog
    FYN, FYN proto-oncogene, Src family tyrosine kinase
  • Vertebrate Orthologs
    10
  • Human Ortholog
    FYN, FYN proto-oncogene, Src family tyrosine kinase
    Orthology source: HomoloGene
  • Synonyms
    p59-FYN, SLK, SYN
  • Links
    NCBI Gene ID: 2534
    neXtProt AC: NX_P06241

  • Chr Location
    6q21; chr6:111660332-111873452 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    77 phenotypes from 8 alleles in 13 genetic backgrounds
    49 phenotypes from multigenic genotypes
    209 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    21
  • Chemically induced (other)
    1
  • Gene trapped
    7
  • Radiation induced
    1
  • Targeted
    6
  • Transgenic
    6
  • Genomic Mutations
    2 involving Fyn
  • Incidental Mutations
Different targeted allele homozygotes show different defects, including seizure susceptibility, anxiety, impaired suckling, myelination, LTP and spatial learning, and defects in immune system, circadian rhythm, testes weight and olfactory bulb formation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000034130 VEGA Gene Model | MGI Sequence Detail 196527 C57BL/6J ±  kb
transcript OTTMUST00000086387 VEGA | MGI Sequence Detail 3528 Not Applicable  
polypeptide OTTMUSP00000046778 VEGA | MGI Sequence Detail 537 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    1400 from dbSNP Build 142
  • RFLP
Protein
Information
less
Molecular
Reagents
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  • All nucleic 33
    Genomic 3
    cDNA 27
    Primer pair 2
    Other 1

    Microarray probesets 5
Other
Accession IDs
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MGD-MRK-9909, MGI:2143602, MGI:2143864
References
more
  • Summaries
    All 351
    Developmental Gene Expression 34
    Gene Ontology 42
    Phenotypes 209
  • Earliest
    J:31022 Kawakami T, et al., Isolation and oncogenic potential of a novel human src-like gene. Mol Cell Biol. 1986 Dec;6(12):4195-201
  • Latest
    J:227983 Kim JE, et al., Fyn is a redox sensor involved in solar ultraviolet light-induced signal transduction in skin carcinogenesis. Oncogene. 2015 Dec 21;

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/15/2016
MGI 6.04
The Jackson Laboratory