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Flg
Gene Detail
 Symbol
Name
ID
Flg
filaggrin
MGI:95553
BioType Conflict
Synonyms fillagrin, ft, profilaggrin
Feature Type protein coding gene
Genetic Map
Chromosome 3
40.16 cM
Detailed Genetic Map ± 1 cM


Mapping data(28)
Sequence Map
Chr3:93273541-93293691 bp, + strand
From VEGA annotation of GRCm38

  20151 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
Gene Tree: Flg
Mutations,
alleles, and
phenotypes
All mutations/alleles(2) : Spontaneous(1) Targeted(1)
Incidental mutations (data from Mutagenetix , APF )
 
Mutations in this gene produce abnormalities in the skin of the ear, tail and dorsal trunk.
 
Human Diseases Modeled Using Mouse Flg (1)    Alleles Annotated to Human Diseases(1)   
Interactions
Flg interacts with 105 markers (Mir7-1, Mir18, Mir18b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (9 annotations)
Process epidermis development, establishment of skin barrier, ...
Component cornified envelope, keratohyalin granule
Function keratin filament binding, metal ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (88 records)
Data Summary: Results (53)    Tissues (29)    Images (23)
Theiler Stages: 22, 23, 24, 25, 26, 28
Assay TypeResults
Immunohistochemistry 25
RNA in situ 2
Northern blot 20
Western blot 6
cDNA source data(8)
External Resources: GEO   Expression Atlas
Molecular
reagents
All nucleic(13) Genomic(3) cDNA(8) Primer pair(2)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000023809 (Evidence)
Ensembl Gene ModelENSMUSG00000081977 (Evidence)
Entrez Gene14246 (Evidence)
DFCITC1599381
DoTSDT.101250918, DT.524321
NIA Mouse Gene IndexU040605, U254082
International Mouse Knockout Project StatusFlg
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000023809 VEGA Gene Model | MGI Sequence Detail 20151 C57BL/6J ±  kb
transcript OTTMUST00000058168 VEGA | MGI Sequence Detail 14502 Not Applicable 
polypeptide P11088 UniProt | EBI | MGI Sequence Detail 336 Not Applicable 

For the selected sequences
All sequences(44) RefSeq(12) UniProt(3)
Polymorphisms RFLP(1) : SNPs within 2kb(82 from dbSNP Build 137)    SNPs within 2kb including multiple locations(94)
Protein-related
information
ResourceIDDescription
InterPro IPR018247 EF-Hand 1, calcium-binding site
InterPro IPR002048 EF-hand domain
InterPro IPR011992 EF-hand-like domain
InterPro IPR013787 S100/CaBP-9k-type, calcium binding, subdomain
InterPro IPR001751 S100/Calbindin-D9k, conserved site
Graphical View of Protein Domain Structure
References (Earliest) J:64247 Lane PW, et al., ft - flaky tail. Mouse News Lett. 1962;27:38
(Latest) J:206433 Chakravarti D, et al., Induced multipotency in adult keratinocytes through down-regulation of DeltaNp63 or DGCR8. Proc Natl Acad Sci U S A. 2014 Feb 4;111(5):E572-81
All references(141)
Disease annotation references (2)
Other
accession IDs
MGD-MRK-9823, MGD-MRK-9881, MGI:2139967, MGI:95587

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory