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Flg
Gene Detail
Symbol

Name
ID
Flg
filaggrin
MGI:95553
Synonyms
fillagrin, ft, profilaggrin
Feature Type
protein coding gene
Genetic Map
Chromosome 3
40.16 cM
Detailed Genetic Map ± 1 cM


Mapping data(28)
Sequence Map
Chr3:93273546-93293689 bp, + strand
From NCBI annotation of GRCm38

  20144 bp   ±  kb flank

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Mouse Genome Browser
Mutations,
alleles, and
phenotypes
All mutations/alleles(2) : Spontaneous(1) Targeted(1)
Incidental mutations (data from Mutagenetix , APF )
 
Mutations in this gene produce abnormalities in the skin of the ear, tail and dorsal trunk.
 
Human Diseases Modeled in Mice Using Flg (1)    Mutations Annotated to Human Diseases (1)   
Interactions
Flg interacts with 104 markers (Mir7-1, Mir18, Mir18b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (96 records)
Data Summary: Results (53)    Tissues (32)    Images (23)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 25
RNA in situ 2
Northern blot 20
Western blot 6
cDNA source data(8)
Other mouse links: GEO   Expression Atlas
Molecular
reagents
All nucleic(13) Genomic(3) cDNA(8) Primer pair(2)
Microarray probesets(3)
Other database
links
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 14246 NCBI Gene Model | MGI Sequence Detail 20144 C57BL/6J ±  kb
transcript AK137664 GenBank | EMBL | DDBJ | MGI Sequence Detail 4523 C57BL/6J 
polypeptide P11088 UniProt | EBI | MGI Sequence Detail 336 Not Applicable 

For the selected sequences
All sequences(64) RefSeq(4) UniProt(11)
Polymorphisms
RFLP(1) : SNPs within 2kb(82 from dbSNP Build 137)    SNPs within 2kb including multiple locations(94)
Protein-related
information
ResourceIDDescription
InterPro IPR018247 EF-Hand 1, calcium-binding site
InterPro IPR002048 EF-hand domain
InterPro IPR011992 EF-hand-like domain
InterPro IPR003303 Filaggrin
InterPro IPR013787 S100/CaBP-9k-type, calcium binding, subdomain
InterPro IPR001751 S100/Calbindin-D9k, conserved site
Graphical View of Protein Domain Structure
References
(Earliest) J:64247 Lane PW, et al., ft - flaky tail. Mouse News Lett. 1962;27:38
(Latest) J:218234 Wurm S, et al., Terminal epidermal differentiation is regulated by the interaction of Fra-2/AP-1 with Ezh2 and ERK1/2. Genes Dev. 2015 Jan 15;29(2):144-56
All references(150)
Disease annotation references (3)
Other
accession IDs
MGD-MRK-9823, MGD-MRK-9881, MGI:2139967, MGI:95587

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory