Flg
Gene Detail

Symbol Name ID

Flg filaggrin MGI:95553

Synonyms

fillagrin, ft, profilaggrin

Feature Type

protein coding gene

Genetic Map

Chromosome 3

40.16 cM
Detailed Genetic Map ± 1 cM


Mapping data(28)

Sequence Map

Chr3:93273541-93282353 bp, + strand From VEGA annotation of GRCm38   8813 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Alleles and phenotypes

All alleles(1) : Spontaneous(1)
 

Mutations in this gene produce abnormalities in the skin of the ear,tail and dorsal trunk.

 

Gene Ontology (GO) classifications

All GO classifications: (5 annotations)

Process	cytoskeleton organization, epidermis development, ...
Component	cornified envelope
Function	metal ion binding

External Resources: FuncBase

Expression

Literature Summary: (81 records)
Data Summary: Results (51)    Tissues (29)    Images (23)
Theiler Stages: 22, 23, 24, 25, 26, 28

Assay Type	Results
Immunohistochemistry	23
RNA in situ	2
Northern blot	20
Western blot	6

cDNA source data(8)
External Resources: GEO   ArrayExpress

Molecular reagents

All nucleic(13) Genomic(3) cDNA(8) Primer pair(2)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000023809 (Evidence)
Ensembl Gene Model	ENSMUSG00000091340 (Evidence), ENSMUSG00000081977 (Evidence), ENSMUSG00000096888 (Evidence), ENSMUSG00000093991 (Evidence), ENSMUSG00000094512 (Evidence), ENSMUSG00000095046 (Evidence), ENSMUSG00000095783 (Evidence)
Entrez Gene	14246 (Evidence)
DFCI	TC1599381
DoTS	DT.101250918, DT.524321
NIA Mouse Gene Index	U040605, U254082
International Mouse Knockout Project Status	Flg

Sequences

Length	Strain/Species
genomic	OTTMUSG00000023809	VEGA Gene Model | MGI Sequence Detail	8813	C57BL/6J
transcript	OTTMUST00000058168	VEGA | MGI Sequence Detail	3164	Not Applicable
polypeptide	OTTMUSP00000028142	VEGA | MGI Sequence Detail	1037	Not Applicable

All sequences(61) RefSeq(4) UniProt(12)

Polymorphisms

RFLP(1) : SNPs(15 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR018247	EF-Hand 1, calcium-binding site
InterPro	IPR002048	EF-hand domain
InterPro	IPR011992	EF-hand-like domain
InterPro	IPR003303	Filaggrin
InterPro	IPR013787	S100/CaBP-9k-type, calcium binding, subdomain
InterPro	IPR001751	S100/Calbindin-D9k, conserved site

References

(Earliest) J:64247 Lane PW, et al., ft - flaky tail. Mouse News Lett. 1962;27:38
(Latest) J:195664 Rice RH, et al., Differentiating inbred mouse strains from each other and those with single gene mutations using hair proteomics. PLoS One. 2012;7(12):e51956
All references(128)

Other accession IDs

MGD-MRK-9823, MGD-MRK-9881, MGI:2139967, MGI:95587