Fkbp1a
Gene Detail

Symbol Name ID

Fkbp1a FK506 binding protein 1a MGI:95541

Synonyms

Fkbp, Fkbp1, FKBP12

Feature Type

protein coding gene

Genetic Map

Chromosome 2

74.83 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr2:151542483-151561692 bp, + strand From VEGA annotation of GRCm38   19210 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:105139  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 2 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Gene Tree: Fkbp1a

Human homologs

Human Homolog		FKBP1A, FK506 binding protein 1A, 12kDa
NCBI Gene ID		2280
neXtProt AC		NX_P62942
Human Synonyms		FKBP1, FKBP12, FKBP-12, FKBP-1A, PKC12, PKCI2, PPIASE
Human Chr (Location)		20p13; chr20:1349621-1373816 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(22) : Targeted(7) Gene trapped(15)
 

Mice homozygous for a null allele display embryonic and neonatal lethality and dilated cardiomyopathy associated with ventricular septal defects, myocardial noncompaction, a thin ventricular wall, hypertrophic trabeculae, and liver hemorrhage and necrosis; about 9% show neural tube closure defects.

 
Human Diseases Modeled Using Mouse Fkbp1a (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (52 annotations)

Process	beta-amyloid formation, cytokine-mediated signaling pathway, ...
Component	axon, axon terminus, ...
Function	activin binding, drug binding, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (2 records)
Data Summary: Results (121)    Tissues (18)    Images (25)
Theiler Stages: 22, 23

Assay Type	Results
RNA in situ	121

cDNA source data(15)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(19) Genomic(3) cDNA(16)
Microarray probesets(6)

Other database links

VEGA Gene Model	OTTMUSG00000015867 (Evidence)
Ensembl Gene Model	ENSMUSG00000032966 (Evidence)
Entrez Gene	14225 (Evidence)
DFCI	TC1573947, TC1613949
DoTS	DT.101408415, DT.101408416, DT.102548579, DT.110665361, DT.40134243, DT.55217086, DT.91556854, DT.94289550, DT.94289554
NIA Mouse Gene Index	U002625, U099662
EC	5.2.1.8
Consensus CDS Project	CCDS16869.1
International Mouse Knockout Project Status	Fkbp1a

Sequences

Length	Strain/Species
genomic	OTTMUSG00000015867	VEGA Gene Model | MGI Sequence Detail	19210	C57BL/6J
transcript	OTTMUST00000037714	VEGA | MGI Sequence Detail	1588	Not Applicable
polypeptide	OTTMUSP00000016918	VEGA | MGI Sequence Detail	161	Not Applicable

All sequences(75) RefSeq(2) UniProt(9)

Polymorphisms

SNPs(21 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR023566	Peptidyl-prolyl cis-trans isomerase, FKBP-type
InterPro	IPR001179	Peptidyl-prolyl cis-trans isomerase, FKBP-type, domain
Protein Ontology	PR:000007536	peptidyl-prolyl cis-trans isomerase FKBP1A

References

(Earliest) J:11570 Nelson PA, et al., cDNA encoding murine FK506-binding protein (FKBP): nucleotide and deduced amino acid sequence. Gene. 1991 Dec 30;109(2):255-8
(Latest) J:183588 Maruyama M, et al., FKBP12 is a critical regulator of the heart rhythm and the cardiac voltage-gated sodium current in mice. Circ Res. 2011 Apr 29;108(9):1042-52
All references(55)

Other accession IDs

MGD-MRK-9808, MGD-MRK-9810