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Fkbp1a
Gene Detail
 Symbol
Name
ID
Fkbp1a
FK506 binding protein 1a
MGI:95541
Synonyms Fkbp, Fkbp1, FKBP12
Feature Type protein coding gene
Genetic Map
Chromosome 2
74.83 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr2:151542483-151561692 bp, + strand
From VEGA annotation of GRCm38

  19210 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:105139  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 2 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Gene Tree: Fkbp1a

Human
homologs
Human Homolog FKBP1A, FK506 binding protein 1A, 12kDa
NCBI Gene ID 2280
neXtProt AC  NX_P62942
Human Synonyms  FKBP1, FKBP12, FKBP-12, FKBP-1A, PKC12, PKCI2, PPIASE
Human Chr (Location)  20p13; chr20:1368977-1393172 (-)  GRCh38
Alleles
and
phenotypes
All alleles(22) : Gene trapped(15) Targeted(7)
 
Mice homozygous for a null allele display embryonic and neonatal lethality and dilated cardiomyopathy associated with ventricular septal defects, myocardial noncompaction, a thin ventricular wall, hypertrophic trabeculae, and liver hemorrhage and necrosis; about 9% show neural tube closure defects.
 
Human Diseases Modeled Using Mouse Fkbp1a (1)    Alleles Annotated to Human Diseases(1)   
Gene Ontology
(GO)
classifications
All GO classifications: (61 annotations)
Process amyloid fibril formation, chaperone-mediated protein folding, ...
Component axon terminus, cell, ...
Function activin binding, calcium channel inhibitor activity, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (121)    Tissues (18)    Images (25)
Theiler Stages: 22, 23
Assay TypeResults
RNA in situ 121
cDNA source data(15)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(19) Genomic(3) cDNA(16)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000015867 (Evidence)
Ensembl Gene ModelENSMUSG00000032966 (Evidence)
Entrez Gene14225 (Evidence)
DFCITC1573947, TC1613949
DoTSDT.101408415, DT.101408416, DT.102548579, DT.110665361, DT.40134243, DT.55217086, DT.91556854, DT.94289550, DT.94289554
NIA Mouse Gene IndexU002625, U099662
EC5.2.1.8
Consensus CDS ProjectCCDS16869.1
International Mouse Knockout Project StatusFkbp1a
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000015867 VEGA Gene Model | MGI Sequence Detail 19210 C57BL/6J ±  kb
transcript OTTMUST00000037714 VEGA | MGI Sequence Detail 1588 Not Applicable 
polypeptide OTTMUSP00000016918 VEGA | MGI Sequence Detail 161 Not Applicable 

For the selected sequences
All sequences(79) RefSeq(7) UniProt(8)
Polymorphisms SNPs within 2kb(25 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR023566 Peptidyl-prolyl cis-trans isomerase, FKBP-type
InterPro IPR001179 Peptidyl-prolyl cis-trans isomerase, FKBP-type, domain
Protein Ontology PR:000007536 peptidyl-prolyl cis-trans isomerase FKBP1A
References (Earliest) J:11570 Nelson PA, et al., cDNA encoding murine FK506-binding protein (FKBP): nucleotide and deduced amino acid sequence. Gene. 1991 Dec 30;109(2):255-8
(Latest) J:195489 Chen H, et al., Fkbp1a controls ventricular myocardium trabeculation and compaction by regulating endocardial Notch1 activity. Development. 2013 May;140(9):1946-57
All references(60)
Other
accession IDs
MGD-MRK-9808, MGD-MRK-9810

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory