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Fgfr4
Gene Detail
Symbol

Name
ID
Fgfr4
fibroblast growth factor receptor 4
MGI:95525
Synonyms
Fgfr-4
Feature Type
protein coding gene
Genetic Map
Chromosome 13
29.80 cM
Detailed Genetic Map ± 1 cM


Mapping data(8)
Sequence Map
Chr13:55152640-55168759 bp, + strand
From VEGA annotation of GRCm38

  16120 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20461  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: fibroblast growth factor receptor
Gene Tree: Fgfr4

Human
homologs
Human Homolog FGFR4, fibroblast growth factor receptor 4
NCBI Gene ID 2264
neXtProt AC  NX_P22455
Human Synonyms  CD334, JTK2, TKF
Human Chr (Location)  5q35.2; chr5:177086905-177098126 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Targeted(7)
Genomic Mutations involving Fgfr4 (1)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for a targeted mutation are viable, healthy and overtly normal, except for a 10% weight reduction at weaning. Mice doubly homozygous for disruptions of Fgfr3 and Fgfr4 show novel phenotypes not seen in either single mutant, including dwarfism and defective respiratory alveogenesis.
 
Alleles Annotated to Human Diseases(2)   
Interactions
Fgfr4 interacts with 68 markers (Mir19a, Mir19b-1, Mir19b-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (49 annotations)
Process alveolar secondary septum development, cell migration, ...
Component cell-cell junction, cytoplasm, ...
Function ATP binding, fibroblast growth factor-activated receptor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (71 records)
Data Summary: Results (483)    Tissues (237)    Images (113)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 5
RNA in situ 377
Northern blot 5
Western blot 2
RT-PCR 94
cDNA source data(35)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(50) cDNA(36) Primer pair(13) Other(1)
Microarray probesets(7)
Other database
links
VEGA Gene ModelOTTMUSG00000035043 (Evidence)
Ensembl Gene ModelENSMUSG00000005320 (Evidence)
Entrez Gene14186 (Evidence)
UniGene276715
DFCITC1586100, TC1601792
DoTSDT.101371209, DT.110955802, DT.524948, DT.91339879, DT.91339880
NIA Mouse Gene IndexU014879
EC2.7.10.1
Consensus CDS ProjectCCDS26540.1
International Mouse Knockout Project StatusFgfr4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000035043 VEGA Gene Model | MGI Sequence Detail 16120 C57BL/6J ±  kb
transcript OTTMUST00000089130 VEGA | MGI Sequence Detail 3324 Not Applicable 
polypeptide OTTMUSP00000048664 VEGA | MGI Sequence Detail 799 Not Applicable 

For the selected sequences
All sequences(39) RefSeq(6) UniProt(5)
Polymorphisms
RFLP(1) : SNPs within 2kb(85 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR013098 Immunoglobulin I-set
InterPro IPR007110 Immunoglobulin-like domain
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR003598 Immunoglobulin subtype 2
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
InterPro IPR008266 Tyrosine-protein kinase, active site
InterPro IPR020635 Tyrosine-protein kinase, catalytic domain
InterPro IPR016248 Tyrosine-protein kinase, fibroblast growth factor receptor
Protein Ontology PR:000001451 fibroblast growth factor receptor 4
References
(Earliest) J:29469 Bottaro DP, et al., Characterization of the receptor for keratinocyte growth factor. Evidence for multiple fibroblast growth factor receptors. J Biol Chem. 1990 Aug 5;265(22):12767-70
(Latest) J:214140 Nakano-Tateno T, et al., FGFR4 polymorphic variants modulate phenotypic features of Cushing disease. Mol Endocrinol. 2014 Apr;28(4):525-33
All references(144)
Other
accession IDs
MGD-MRK-9779, MGD-MRK-9784

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/16/2014
MGI 5.20
The Jackson Laboratory