Fgfr4
Gene Detail

Symbol Name ID

Fgfr4 fibroblast growth factor receptor 4 MGI:95525

Synonyms

Fgfr-4

Feature Type

protein coding gene

Genetic Map

Chromosome 13

29.80 cM
Detailed Genetic Map ± 1 cM


Mapping data(8)

Sequence Map

Chr13:55152640-55168759 bp, + strand From VEGA annotation of GRCm38   16120 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:20461  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: fibroblast growth factor receptor
Gene Tree: Fgfr4

Human homologs

Human Homolog		FGFR4, fibroblast growth factor receptor 4
NCBI Gene ID		2264
neXtProt AC		NX_P22455
Human Synonyms		CD334, JTK2, TKF
Human Chr (Location)		5q35.1-qter; chr5:176513921-176525127 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(5) : Targeted(5)
 

Homozygotes for a targeted mutation are viable, healthy and overtly normal, except for a 10% weight reduction at weaning. Mice doubly homozygous for disruptions of Fgfr3 and Fgfr4 show novel phenotypes not seen in either single mutant, including dwarfism and defective respiratory alveogenesis.

 
Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (49 annotations)

Process	alveolar secondary septum development, cell migration, ...
Component	cell-cell junction, cytoplasm, ...
Function	ATP binding, fibroblast growth factor-activated receptor activity, ...

External Resources: FuncBase

Expression

Literature Summary: (68 records)
Data Summary: Results (470)    Tissues (225)    Images (101)
Theiler Stages: 2, 3, 4, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 28

Assay Type	Results
Immunohistochemistry	5
RNA in situ	365
Northern blot	4
Western blot	2
RT-PCR	94

cDNA source data(33)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(47) cDNA(34) Primer pair(12) Other(1)
Microarray probesets(7)

Other database links

VEGA Gene Model	OTTMUSG00000035043 (Evidence)
Ensembl Gene Model	ENSMUSG00000005320 (Evidence)
Entrez Gene	14186 (Evidence)
UniGene	276715
DFCI	TC1586100, TC1601792
DoTS	DT.101371209, DT.110955802, DT.524948, DT.91339879, DT.91339880
NIA Mouse Gene Index	U014879
EC	2.7.10.1
Consensus CDS Project	CCDS26540.1
International Mouse Knockout Project Status	Fgfr4

Sequences

Length	Strain/Species
genomic	OTTMUSG00000035043	VEGA Gene Model | MGI Sequence Detail	16120	C57BL/6J
transcript	OTTMUST00000089130	VEGA | MGI Sequence Detail	3324	Not Applicable
polypeptide	OTTMUSP00000048664	VEGA | MGI Sequence Detail	799	Not Applicable

All sequences(33) RefSeq(2) UniProt(3)

Polymorphisms

RFLP(1) : SNPs(59 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR013098	Immunoglobulin I-set
InterPro	IPR007110	Immunoglobulin-like domain
InterPro	IPR013783	Immunoglobulin-like fold
InterPro	IPR003598	Immunoglobulin subtype 2
InterPro	IPR017441	Protein kinase, ATP binding site
InterPro	IPR000719	Protein kinase, catalytic domain
InterPro	IPR011009	Protein kinase-like domain
InterPro	IPR001245	Serine-threonine/tyrosine-protein kinase catalytic domain
InterPro	IPR008266	Tyrosine-protein kinase, active site
InterPro	IPR020635	Tyrosine-protein kinase, catalytic domain
InterPro	IPR016248	Tyrosine-protein kinase, fibroblast growth factor receptor
Protein Ontology	PR:000001451	fibroblast growth factor receptor 4
Protein Ontology	PR:000025671	fibroblast growth factor receptor 4 (mouse)

References

(Earliest) J:29469 Bottaro DP, et al., Characterization of the receptor for keratinocyte growth factor. Evidence for multiple fibroblast growth factor receptors. J Biol Chem. 1990 Aug 5;265(22):12767-70
(Latest) J:192712 Meadows SM, et al., Integration of repulsive guidance cues generates avascular zones that shape mammalian blood vessels. Circ Res. 2012 Jan 6;110(1):34-46
All references(136)

Other accession IDs

MGD-MRK-9779, MGD-MRK-9784