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Fgfr4 Gene Detail
Summary
  • Symbol
    Fgfr4
  • Name
    fibroblast growth factor receptor 4
  • Synonyms
    Fgfr-4
  • Feature Type
    protein coding gene
  • IDs
    MGI:95525
    NCBI Gene: 14186
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr13:55152640-55168759 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      16120 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 13, 29.80 cM
  • Mapping Data
    8 experiments
Homology
more
  • Human Ortholog
    FGFR4, fibroblast growth factor receptor 4
  • Vertebrate Orthologs
    10
  • Human Ortholog
    FGFR4, fibroblast growth factor receptor 4
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CD334, JTK2, TKF
  • Links
    NCBI Gene ID: 2264
    neXtProt AC: NX_P22455
    UniProt: P22455

  • Chr Location
    5q35.2; chr5:177086872-177098144 (+)  GRCh38.p7

Human Diseases
less
  • Mutations/Alleles
    2 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 3 alleles in 3 genetic backgrounds
    14 phenotypes from multigenic genotypes
    39 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygotes for a targeted mutation are viable, healthy and overtly normal, except for a 10% weight reduction at weaning. Mice doubly homozygous for disruptions of Fgfr3 and Fgfr4 show novel phenotypes not seen in either single mutant, including dwarfismand defective respiratory alveogenesis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000035043 VEGA Gene Model | MGI Sequence Detail 16120 C57BL/6J ±  kb
    transcript OTTMUST00000089130 VEGA | MGI Sequence Detail 3324 Not Applicable  
    polypeptide OTTMUSP00000048664 VEGA | MGI Sequence Detail 799 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      85 from dbSNP Build 142
    • RFLP
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 52
      cDNA 38
      Primer pair 13
      Other 1

      Microarray probesets 7
    Other
    Accession IDs
    less
    MGD-MRK-9779, MGD-MRK-9784
    References
    more
    • Summaries
      All 176
      Developmental Gene Expression 86
      Diseases 3
      Gene Ontology 15
      Phenotypes 39
    • Earliest
      J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
    • Latest
      J:263102 Takeshita A, et al., Central role of the proximal tubular alphaKlotho/FGF receptor complex in FGF23-regulated phosphate and vitamin D metabolism. Sci Rep. 2018 May 2;8(1):6917

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    07/31/2018
    MGI 6.12
    The Jackson Laboratory