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Fgfr4 Gene Detail
Summary
  • Symbol
    Fgfr4
  • Name
    fibroblast growth factor receptor 4
  • Synonyms
    Fgfr-4
  • Feature Type
    protein coding gene
  • IDs
    MGI:95525
    NCBI Gene: 14186
Location & Maps
more
  • Sequence Map
    Chr13:55152640-55168759 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      16120 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 13, 29.80 cM
  • Mapping Data
    8 experiments
Homology
more
  • Human Ortholog
    FGFR4, fibroblast growth factor receptor 4
  • Vertebrate Orthologs
    10
  • Human Ortholog
    FGFR4, fibroblast growth factor receptor 4
    Orthology source: HomoloGene
  • Synonyms
    CD334, JTK2, TKF
  • Links
    NCBI Gene ID: 2264
    neXtProt AC: NX_P22455

  • Chr Location
    5q35.2; chr5:177086872-177098142 (+)  GRCh38.p2

Human Diseases
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  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 3 alleles in 3 genetic backgrounds
    14 phenotypes from multigenic genotypes
    32 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    8
  • Chemically induced (other)
    1
  • Targeted
    7
  • Genomic Mutations
    2 involving Fgfr4
  • Incidental Mutations
Homozygotes for a targeted mutation are viable, healthy and overtly normal, except for a 10% weight reduction at weaning. Mice doubly homozygous for disruptions of Fgfr3 and Fgfr4 show novel phenotypes not seen in either single mutant, including dwarfismand defective respiratory alveogenesis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000035043 VEGA Gene Model | MGI Sequence Detail 16120 C57BL/6J ±  kb
transcript OTTMUST00000089130 VEGA | MGI Sequence Detail 3324 Not Applicable  
polypeptide OTTMUSP00000048664 VEGA | MGI Sequence Detail 799 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    85 from dbSNP Build 142
  • RFLP
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 51
    cDNA 37
    Primer pair 13
    Other 1

    Microarray probesets 7
Other
Accession IDs
less
MGD-MRK-9779, MGD-MRK-9784
References
more
  • Summaries
    All 147
    Developmental Gene Expression 77
    Diseases 2
    Gene Ontology 13
    Phenotypes 32
  • Earliest
    J:29469 Bottaro DP, et al., Characterization of the receptor for keratinocyte growth factor. Evidence for multiple fibroblast growth factor receptors. J Biol Chem. 1990 Aug 5;265(22):12767-70
  • Latest
    J:228212 Cinque L, et al., FGF signalling regulates bone growth through autophagy. Nature. 2015 Dec 10;528(7581):272-5

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
07/12/2016
MGI 6.04
The Jackson Laboratory