Sequence Detail

ID/Version

Q03142 Q27Q87 Q8C3V5 Q5J7D9 Q8CIB8 (UniProt | EBI)

Last sequence update: 2006-03-21
Last annotation update: 2024-01-24

Sequence description from provider

RecName: Full=Fibroblast growth factor receptor 4; Short=FGFR-4; EC=2.7.10.1;AltName: Full=Protein-tyrosine kinase receptor MPK-11;AltName: CD_antigen=CD334;Flags: Precursor;

Provider

SWISS-PROT

Sequence

Polypeptide 799 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Fgfr4	fibroblast growth factor receptor 4	70	155	3	14

Sequence references in MGI

J:3319 Gilardi-Hebenstreit P, et al., An Eph-related receptor protein tyrosine kinase gene segmentally expressed in the developing mouse hindbrain [published erratum appears in Oncogene 1993 Apr;8(4):1103]. Oncogene. 1992 Dec;7(12):2499-506
J:11593 Stark KL, et al., FGFR-4, a new member of the fibroblast growth factor receptor family, expressed in the definitive endoderm and skeletal muscle lineages of the mouse. Development. 1991 Oct;113(2):641-51
J:50677 Weinstein M, et al., FGFR-3 and FGFR-4 function cooperatively to direct alveogenesis in the murine lung. Development. 1998 Sep;125(18):3615-23
J:62267 Yu C, et al., Elevated cholesterol metabolism and bile acid synthesis in mice lacking membrane tyrosine kinase receptor FGFR4. J Biol Chem. 2000 May 19;275(20):15482-9
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:121336 Ogawa Y, et al., BetaKlotho is required for metabolic activity of fibroblast growth factor 21. Proc Natl Acad Sci U S A. 2007 May 1;104(18):7432-7
J:126527 Huang X, et al., FGFR4 prevents hyperlipidemia and insulin resistance but underlies high-fat diet induced fatty liver. Diabetes. 2007 Oct;56(10):2501-10
J:132070 Kwiatkowski BA, et al., FGFR4 and its novel splice form in myogenic cells: Interplay of glycosylation and tyrosine phosphorylation. J Cell Physiol. 2008 Jan 9;215(3):803-817
J:149773 Shin DJ, et al., FGF15/FGFR4 integrates growth factor signaling with hepatic bile acid metabolism and insulin action. J Biol Chem. 2009 Apr 24;284(17):11110-20
J:175280 Gattineni J, et al., Regulation of serum 1,25(OH)2Vitamin D3 levels by fibroblast growth factor 23 is mediated by FGF receptors 3 and 4. Am J Physiol Renal Physiol. 2011 Aug;301(2):F371-7
J:228280 Ulaganathan VK, et al., Germline variant FGFR4 p.G388R exposes a membrane-proximal STAT3 binding site. Nature. 2015 Dec 24;528(7583):570-4