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Fcgr2b
Gene Detail
Symbol

Name
ID
Fcgr2b
Fc receptor, IgG, low affinity IIb
MGI:95499
STS
Synonyms
CD32, F630109E10Rik, FcgammaRIIB, Fc gamma RIIB, Fcgr2, Fcgr2a, FcgRII, Fc[g]RII, Fcr-2, Fcr-3, Ly-17, LyM-1, Ly-m20
Feature Type
protein coding gene
Genetic Map
Chromosome 1
78.02 cM
Detailed Genetic Map ± 1 cM


Mapping data(72)
Sequence Map
Chr1:170960558-170976547 bp, - strand
From VEGA annotation of GRCm38

  15990 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2974  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 2 cattle; 1 dog

Protein SuperFamily: Fc gamma receptor III
Gene Tree: Fcgr2b

Human
homologs
Human Homolog FCGR2B, Fc fragment of IgG, low affinity IIb, receptor (CD32)
NCBI Gene ID 2213
neXtProt AC  NX_P31994
Human Synonyms  CD32, CD32B, FCG2, FCGR2, IGFR2
Human Chr (Location)  1q23; chr1:161663115-161678654 (+)  GRCh38
Disease Associations  (2) Diseases Associated with Human FCGR2B
Mutations,
alleles, and
phenotypes
All mutations/alleles(14) : Gene trapped(6) Not Specified(1) Targeted(7)
Genomic Mutations involving Fcgr2b (2)
Incidental mutations (data from Mutagenetix , APF )
 
Mutants show increased antibody response, passive cutaneous analphylaxis, autoantibodies and arthritis susceptibility. On C57BL/6, mice die by 9 months with anemia, proteinuria, glomerulonephritis, and inflammatory disease. A strain variant controls expression in germinal center B cells.
 
Human Diseases Modeled Using Mouse Fcgr2b (2)    Alleles Annotated to Human Diseases(1)    Phenotype Images(1)
Interactions
Fcgr2b interacts with 76 markers (Mir15a, Mir15b, Mir16-1, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (3 records)
Data Summary: Results (3)    Tissues (3)    Tissue x Stage Matrix (view)
Assay TypeResults
RT-PCR 3
cDNA source data(52)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(63) Genomic(6) cDNA(56) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000021775 (Evidence)
Ensembl Gene ModelENSMUSG00000026656 (Evidence)
Entrez Gene14130 (Evidence)
UniGene425062
DFCITC1575453, TC1590513, TC1603456
DoTSDT.101155501, DT.101405410, DT.101706304, DT.91481894, DT.99868218
NIA Mouse Gene IndexU022042
Consensus CDS ProjectCCDS35769.1, CCDS35770.1
International Mouse Knockout Project StatusFcgr2b
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021775 VEGA Gene Model | MGI Sequence Detail 15990 C57BL/6J ±  kb
transcript OTTMUST00000051686 VEGA | MGI Sequence Detail 1603 Not Applicable 
polypeptide OTTMUSP00000024374 VEGA | MGI Sequence Detail 340 Not Applicable 

For the selected sequences
All sequences(68) RefSeq(6) UniProt(5)
Polymorphisms
RFLP(4) : SNPs within 2kb(410 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR007110 Immunoglobulin-like domain
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR003599 Immunoglobulin subtype
Protein Ontology PR:000001479 low affinity immunoglobulin gamma Fc region receptor II
References
(Earliest) J:5896 Dickler HB, et al., B-lymphocyte Fc receptor-associated non-H-2 antigens are determined by a single polymorphic locus which is linked to the Mls locus. J Exp Med. 1977 Dec 1;146(6):1678-92
(Latest) J:212944 Zhang G, et al., Fcgamma receptor-mediated inflammation inhibits axon regeneration. PLoS One. 2014;9(2):e88703
All references(341)
Disease annotation references (3)
Other
accession IDs
MGD-MRK-11955, MGD-MRK-12013, MGD-MRK-12069, MGD-MRK-12070, MGD-MRK-9733, MGD-MRK-9734, MGD-MRK-9735, MGD-MRK-9739, MGD-MRK-9740, MGI:2138286, MGI:2445072

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/18/2014
MGI 5.20
The Jackson Laboratory