Fcgr2b
Gene Detail

Symbol Name ID

Fcgr2b Fc receptor, IgG, low affinity IIb MGI:95499

STS

D1Nds8

Synonyms

CD32, F630109E10Rik, FcgammaRIIB, Fc gamma RIIB, Fcgr2, Fcgr2a, FcgRII, Fc[g]RII, Fcr-2, Fcr-3, Ly-17, LyM-1, Ly-m20

Feature Type

protein coding gene

Genetic Map

Chromosome 1

78.02 cM
Detailed Genetic Map ± 1 cM


Mapping data(73)

Sequence Map

Chr1:170960558-170976547 bp, - strand From VEGA annotation of GRCm38   15990 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:2974  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 2 cattle; 1 dog

Protein SuperFamily: Fc gamma receptor III
Gene Tree: Fcgr2b

Human homologs

Human Homolog		FCGR2B, Fc fragment of IgG, low affinity IIb, receptor (CD32)
NCBI Gene ID		2213
neXtProt AC		NX_P31994
Human Synonyms		CD32, CD32B, FCG2, FCGR2, IGFR2
Human Chr (Location)		1q23; chr1:161632905-161648444 (+)  GRCh37.p10
Disease Associations		(2) Diseases Associated with Human FCGR2B

Alleles and phenotypes

All alleles(11) : Targeted(5) Gene trapped(6)
 

Mutants show increased antibody response, passive cutaneous analphylaxis, autoantibodies and arthritis susceptibility. On C57BL/6, mice die by 9 months with anemia, proteinuria, glomerulonephritis, and inflammatory disease. A strain variant controls expression in germinal center B cells.

 
Human Diseases Modeled Using Mouse Fcgr2b (2)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (31 annotations)

Process	antigen processing and presentation of exogenous peptide antigen via MHC class II, cell surface receptor signaling pathway, ...
Component	cytoplasm, cytoskeleton, ...
Function	IgG binding, protein binding, ...

External Resources: FuncBase

Expression

Literature Summary: (3 records)
Data Summary: Results (3)    Tissues (3)   
Theiler Stages: 20, 22, 28

Assay Type	Results
RT-PCR	3

cDNA source data(52)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(63) Genomic(6) cDNA(56) Primer pair(1)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000021775 (Evidence)
Ensembl Gene Model	ENSMUSG00000026656 (Evidence)
Entrez Gene	14130 (Evidence)
UniGene	425062
DFCI	TC1575453, TC1590513, TC1603456
DoTS	DT.101155501, DT.101405410, DT.101706304, DT.91481894, DT.99868218
NIA Mouse Gene Index	U022042
Consensus CDS Project	CCDS35769.1, CCDS35770.1
International Mouse Knockout Project Status	Fcgr2b

Sequences

Length	Strain/Species
genomic	OTTMUSG00000021775	VEGA Gene Model | MGI Sequence Detail	15990	C57BL/6J
transcript	OTTMUST00000051686	VEGA | MGI Sequence Detail	1603	Not Applicable
polypeptide	OTTMUSP00000024374	VEGA | MGI Sequence Detail	340	Not Applicable

All sequences(62) RefSeq(4) UniProt(3)

Polymorphisms

RFLP(4) : SNPs(280 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR007110	Immunoglobulin-like domain
InterPro	IPR013783	Immunoglobulin-like fold
InterPro	IPR003599	Immunoglobulin subtype
Protein Ontology	PR:000001479	low affinity immunoglobulin gamma Fc region receptor II

References

(Earliest) J:5896 Dickler HB, et al., B-lymphocyte Fc receptor-associated non-H-2 antigens are determined by a single polymorphic locus which is linked to the Mls locus. J Exp Med. 1977 Dec 1;146(6):1678-92
(Latest) J:195527 Othy S, et al., Intravenous Gammaglobulin Inhibits Encephalitogenic Potential of Pathogenic T Cells and Interferes with their Trafficking to the Central Nervous System, Implicating Sphingosine-1 Phosphate Receptor 1-Mammalian Target of Rapamycin Axis. J Immunol. 2013 May 1;190(9):4535-41
All references(315)

Other accession IDs

MGD-MRK-11955, MGD-MRK-12013, MGD-MRK-12069, MGD-MRK-12070, MGD-MRK-9733, MGD-MRK-9734, MGD-MRK-9735, MGD-MRK-9739, MGD-MRK-9740, MGI:2138286, MGI:2445072