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Gene Detail
excision repair cross-complementing rodent repair deficiency, complementation group 3
Synonyms XPB
Feature Type protein coding gene
Genetic Map
Chromosome 18
17.97 cM, cytoband B3
Detailed Genetic Map ± 1 cM

Mapping data(2)
Sequence Map
Chr18:32240300-32270151 bp, + strand
From VEGA annotation of GRCm38

  29852 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
HomoloGene:96  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: DNA excision repair cross-complementing protein ERCC3
Gene Tree: Ercc3

Human Homolog ERCC3, excision repair cross-complementation group 3
NCBI Gene ID 2071
neXtProt AC  NX_P19447
Human Synonyms  BTF2, GTF2H, RAD25, TFIIH, XPB
Human Chr (Location)  2q21; chr2:127257290-127294176 (-)  GRCh38
Disease Associations  (2) Diseases Associated with Human ERCC3
alleles, and
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
Mice homozygous for a frame shift mutation in exon 15 exhibit embryonic lethality prior to E8.5. Mice homozygous for a frame shift mutation following by a stop codon insertion in exon 15 exhibit increased sensitivity to ultraviolet- and gamma-irradiation.
Human Diseases Modeled Using Mouse Ercc3 (1)    Alleles Annotated to Human Diseases(1)   
Ercc3 interacts with 95 markers (Mir7-2, Mir7b, Mir34b, ...)
Gene Ontology
All GO classifications: (44 annotations)
Process apoptotic process, ATP catabolic process, ...
Component core TFIIH complex, holo TFIIH complex, ...
Function 3'-5' DNA helicase activity, ATPase activity, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Literature Summary: (3 records)
Data Summary: Results (34)    Tissues (26)   
Theiler Stages: 14, 17, 18, 20, 22, 23, 26, 27, 28
Assay TypeResults
RNA in situ 18
Northern blot 16
cDNA source data(81)
External Resources: Allen Institute   GEO   Expression Atlas
All nucleic(87) Genomic(6) cDNA(81)
Microarray probesets(3)
Other database
VEGA Gene ModelOTTMUSG00000023961 (Evidence)
Ensembl Gene ModelENSMUSG00000024382 (Evidence)
Entrez Gene13872 (Evidence)
DFCITC1574709, TC1604746
DoTSDT.101231291, DT.491117
NIA Mouse Gene IndexU018523
Consensus CDS ProjectCCDS29118.1
International Mouse Knockout Project StatusErcc3
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000023961 VEGA Gene Model | MGI Sequence Detail 29852 C57BL/6J ±  kb
transcript OTTMUST00000058560 VEGA | MGI Sequence Detail 2708 Not Applicable 
polypeptide OTTMUSP00000028389 VEGA | MGI Sequence Detail 783 Not Applicable 

For the selected sequences
All sequences(39) RefSeq(5) UniProt(4)
Polymorphisms SNPs within 2kb(114 from dbSNP Build 137)
InterPro IPR001650 Helicase, C-terminal
InterPro IPR001161 Helicase Ercc3
InterPro IPR014001 Helicase, superfamily 1/2, ATP-binding domain
InterPro IPR006935 Helicase/UvrB domain
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
Protein Ontology PR:000007165 TFIIH basal transcription factor complex helicase XPB subunit
References (Earliest) J:1626 Weeda G, et al., Characterization of the mouse homolog of the XPBC/ERCC-3 gene implicated in xeroderma pigmentosum and Cockayne's syndrome. Carcinogenesis. 1991 Dec;12(12):2361-8
(Latest) J:201955 Mourgues S, et al., ELL, a novel TFIIH partner, is involved in transcription restart after DNA repair. Proc Natl Acad Sci U S A. 2013 Oct 29;110(44):17927-32
All references(37)
Disease annotation references (1)
accession IDs
MGD-MRK-9577, MGD-MRK-9580

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 5.19
The Jackson Laboratory