Ercc3
Gene Detail

Symbol Name ID

Ercc3 excision repair cross-complementing rodent repair deficiency, complementation group 3 MGI:95414

Synonyms

Ercc-3

Feature Type

protein coding gene

Genetic Map

Chromosome 18

17.97 cM, cytoband B3
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr18:32240300-32270151 bp, + strand From VEGA annotation of GRCm38   29852 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:96  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: DNA excision repair cross-complementing protein ERCC3
Gene Tree: Ercc3

Human homologs

Human Homolog		ERCC3, excision repair cross-complementing rodent repair deficiency, complementation group 3
NCBI Gene ID		2071
neXtProt AC		NX_P19447
Human Synonyms		BTF2, GTF2H, RAD25, TFIIH, XPB
Human Chr (Location)		2q21; chr2:128014866-128051752 (-)  GRCh37.p10
Disease Associations		(2) Diseases Associated with Human ERCC3

Alleles and phenotypes

All alleles(3) : Targeted(3)
 

Mice homozygous for a frame shift mutation in exon 15 exhibit embryonic lethality prior to E8.5. Mice homozygous for a frame shift mutation following by a stop codon insertion in exon 15 exhibit increased sensitivity to ultraviolet- and gamma-irradiation.

 
Human Diseases Modeled Using Mouse Ercc3 (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (45 annotations)

Process	ATP catabolic process, cell cycle checkpoint, ...
Component	holo TFIIH complex, nucleus, ...
Function	3'-5' DNA helicase activity, ATPase activity, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (3 records)
Data Summary: Results (34)    Tissues (23)   
Theiler Stages: 14, 17, 18, 20, 22, 23, 26, 28

Assay Type	Results
RNA in situ	18
Northern blot	16

cDNA source data(19)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(25) Genomic(6) cDNA(19)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000023961 (Evidence)
Ensembl Gene Model	ENSMUSG00000024382 (Evidence)
Entrez Gene	13872 (Evidence)
DFCI	TC1574709, TC1604746
DoTS	DT.101231291, DT.491117
NIA Mouse Gene Index	U018523
EC	3.6.4.12
Consensus CDS Project	CCDS29118.1
International Mouse Knockout Project Status	Ercc3

Sequences

Length	Strain/Species
genomic	OTTMUSG00000023961	VEGA Gene Model | MGI Sequence Detail	29852	C57BL/6J
transcript	OTTMUST00000058560	VEGA | MGI Sequence Detail	2708	Not Applicable
polypeptide	OTTMUSP00000028389	VEGA | MGI Sequence Detail	783	Not Applicable

All sequences(36) RefSeq(2) UniProt(4)

Polymorphisms

SNPs(111 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001650	Helicase, C-terminal
InterPro	IPR014001	Helicase, superfamily 1/2, ATP-binding domain
InterPro	IPR006935	Helicase/UvrB domain
InterPro	IPR001161	Xeroderma pigmentosum group B protein (XP-B)
Protein Ontology	PR:000007165	TFIIH basal transcription factor complex helicase XPB subunit

References

(Earliest) J:1626 Weeda G, et al., Characterization of the mouse homolog of the XPBC/ERCC-3 gene implicated in xeroderma pigmentosum and Cockayne's syndrome. Carcinogenesis. 1991 Dec;12(12):2361-8
(Latest) J:188614 Godon C, et al., Generation of DNA single-strand displacement by compromised nucleotide excision repair. EMBO J. 2012 Aug 29;31(17):3550-63
All references(35)

Other accession IDs

MGD-MRK-9577, MGD-MRK-9580