Phenotypes Associated with This Genotype

Genotype
MGI:3836472

• Allelic Composition: Ercc3^tm2Jhjh/Ercc3^tm2Jhjh
• Genetic Background: B6.129P2-Ercc3^tm2Jhjh

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

mortality/aging ( J:145759 )

N • mice are born in Mendelian frequencies and exhibit normal mortality and aging

cellular

increased cellular sensitivity to gamma-irradiation ( J:145759 )

• slightly

increased cellular sensitivity to ultraviolet irradiation ( J:145759 )

• mice exhibit greater sensitivity to UV irradiation than wild-type cells but not as much a in Xpa^tm1Hvs homozygous cells

integument

acanthosis ( J:145759 )

• moderately enhanced following UV irradiation

epidermal hyperplasia ( J:145759 )

• following UV irradiation

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
xeroderma pigmentosum group B		DOID:0110850	OMIM:610651	J:145759