Ercc3 Phenotype Annotations - Multigenic Genotypes

Mammalian Phenotype Ontology Annotations
Query Results - Summary

Symbol
Name
ID

Ercc3
excision repair cross-complementing rodent repair deficiency, complementation group 3
MGI:95414

24 phenotypes from multigenic genotypes

Allelic Composition Genetic Background	Annotated Term	Reference
Ercc2^{tm2(ERCC2)Jhjh}/Ercc2^{tm2(ERCC2)Jhjh} Ercc3^tm2Jhjh/Ercc3^tm2Jhjh involves: 129P2/OlaHsd * C57BL/6	increased cellular sensitivity to gamma-irradiation induced cell death	J:145759
	increased cellular sensitivity to oxidative stress	J:145759
	increased cellular sensitivity to ultraviolet irradiation induced cell death	J:145759
	postnatal growth retardation	J:145759
	postnatal lethality, complete penetrance	J:145759
Ercc3^tm1.1Gima/Ercc3^tm1.1Gima either: (involves: 129P2/OlaHsd * C57BL/6) or (involves: 129P2/OlaHsd * FVB)	normal cellular phenotype	J:154596
	normal mortality/aging	J:154596
	normal neoplasm	J:154596
	normal reproductive system phenotype	J:154596
Ercc3^tm1.1Gima/Ercc3^tm1.1Gima Xpc^tm1Ecf/Xpc^tm1Ecf either: (involves: 129/Sv * 129P2/OlaHsd * C57BL/6) or (involves: 129/Sv * 129P2/OlaHsd * FVB/N)	increased cellular sensitivity to ultraviolet irradiation induced cell death	J:154596
Ercc3^tm2Jhjh/Ercc3^tm2Jhjh Xpa^tm1Hvs/Xpa^tm1Hvs involves: 129P2/OlaHsd * C57BL/6	abnormal cranium morphology	J:145759
	abnormal gait	J:145759
	ataxia	J:145759
	cachexia	J:145759
	decreased body weight	J:145759
	hyperactivity	J:145759
	impaired balance	J:145759
	impaired limb coordination	J:145759
	increased cellular sensitivity to gamma-irradiation induced cell death	J:145759
	increased cellular sensitivity to oxidative stress	J:145759
	increased cellular sensitivity to ultraviolet irradiation induced cell death	J:145759
	kyphosis	J:145759
	muscle hypertonia	J:145759
	premature aging	J:145759
	premature death	J:145759
	slow postnatal weight gain	J:145759
	testicular atrophy	J:145759
	tremors	J:145759

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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