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Ephx1 Gene Detail
Summary
  • Symbol
    Ephx1
  • Name
    epoxide hydrolase 1, microsomal
  • Synonyms
    Eph1, Eph-1, mEH
  • Feature Type
    protein coding gene
  • IDs
    MGI:95405
    NCBI Gene: 13849
  • Gene Overview
    MyGene.info: EPHX1
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:180989556-181017569 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 84.48 cM
  • Mapping Data
    13 experiments
Strain
Comparison
more
  • SNPs within 2kb
    319 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_95405
protein coding gene Chr1:180976210-181020904 (-)
129S1/SvImJ MGP_129S1SvImJ_G0016880
protein coding gene Chr1:187460320-187506279 (-)
A/J MGP_AJ_G0016859
protein coding gene Chr1:179869402-179915808 (-)
AKR/J MGP_AKRJ_G0016825
protein coding gene Chr1:185215050-185261915 (-)
BALB/cJ MGP_BALBcJ_G0016817
protein coding gene Chr1:180490615-180534911 (-)
C3H/HeJ MGP_C3HHeJ_G0016642
protein coding gene Chr1:185989296-186035480 (-)
C57BL/6NJ MGP_C57BL6NJ_G0017280
protein coding gene Chr1:193548432-193600390 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014988
protein coding gene Chr1:170842563-170887301 (-)
CAST/EiJ MGP_CASTEiJ_G0016223
protein coding gene Chr1:185334546-185383637 (-)
CBA/J MGP_CBAJ_G0016616
protein coding gene Chr1:200680779-200728941 (-)
DBA/2J MGP_DBA2J_G0016722
protein coding gene Chr1:178702879-178747320 (-)
FVB/NJ MGP_FVBNJ_G0016718
protein coding gene Chr1:176802928-176847816 (-)
LP/J MGP_LPJ_G0016796
protein coding gene Chr1:188710360-188761275 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0016749
protein coding gene Chr1:207848003-207893903 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0017317
protein coding gene Chr1:184993673-185042577 (-)
PWK/PhJ MGP_PWKPhJ_G0016011
protein coding gene Chr1:177819463-177864661 (-)
SPRET/EiJ MGP_SPRETEiJ_G0015787
protein coding gene Chr1:183929976-183989268 (-)
WSB/EiJ MGP_WSBEiJ_G0016286
protein coding gene Chr1:185196660-185243798 (-)



Homology
more
  • Human Ortholog
    EPHX1, epoxide hydrolase 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    EPHX1, epoxide hydrolase 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    EPHX, EPOX, HYL1, MEH
  • Links
    NCBI Gene ID: 2052
    neXtProt AC: NX_P07099
    UniProt: P07099

  • Chr Location
    1q42.12; chr1:225810074-225845563 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele are highly resistant to DMBA-induced skin carcinogenesis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 13849 NCBI Gene Model | MGI Sequence Detail 28014 C57BL/6J ±  kb
transcript NM_010145 RefSeq | MGI Sequence Detail 1754 C57BL/6  
polypeptide Q9D379 UniProt | EBI | MGI Sequence Detail 455 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 169
    cDNA 168
    Primer pair 1

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-9563, MGD-MRK-9564, MGI:2138172
References
more
  • Summaries
    All 56
    Developmental Gene Expression 3
    Gene Ontology 5
    Phenotypes 11
  • Earliest
    J:6369 Lyman SD, et al., Genetic polymorphism of microsomal epoxide hydrolase activity in the mouse. J Biol Chem. 1980 Sep 25;255(18):8650-4
  • Latest
    J:194239 Sirish P, et al., Unique mechanistic insights into the beneficial effects of soluble epoxide hydrolase inhibitors in the prevention of cardiac fibrosis. Proc Natl Acad Sci U S A. 2013 Apr 2;110(14):5618-23

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
01/08/2019
MGI 6.13
The Jackson Laboratory