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Ephx1
Gene Detail
Symbol

Name
ID
Ephx1
epoxide hydrolase 1, microsomal
MGI:95405
Synonyms
Eph1, Eph-1, mEH
Feature Type
protein coding gene
Genetic Map
Chromosome 1
84.48 cM
Detailed Genetic Map ± 1 cM


Mapping data(13)
Sequence Map
Chr1:180976210-181020904 bp, - strand
From VEGA annotation of GRCm38

  44695 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:94  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: EPHX1
Protein SuperFamily: epoxide hydrolase
Gene Tree: Ephx1

Human
homologs
EPHX1, epoxide hydrolase 1, microsomal (xenobiotic)
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 2052
neXtProt AC: NX_P07099

Human Synonyms: EPHX, EPOX, HYL1, MEH

Human Chr (Location): 1q42.1; chr1:225810074-225845563 (+)  GRCh38.p2

Disease Associations: (3) Diseases Associated with Human EPHX1

Mutations,
alleles, and
phenotypes
All mutations/alleles(14) : Gene trapped(8) Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele are highly resistant to DMBA-induced skin carcinogenesis.
 
Interactions
Ephx1 interacts with 29 markers (Mir1b, Mir134, Mir141, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (3 records)
Data Summary: Results (223)    Tissues (109)    Images (39)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 223
cDNA source data(166)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase ephx1 ; ZFIN ephx1    NEW 
Molecular
reagents
All nucleic(168) cDNA(167) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000021983 (Evidence)
Ensembl Gene Model ENSMUSG00000038776 (Evidence)
Entrez Gene 13849 (Evidence)
UniGene 9075
DFCI TC1661957, TC1572693
DoTS DT.101266074, DT.55100658
EC 3.3.2.9
Consensus CDS Project CCDS15579.1
International Mouse Phenotyping Consortium Status Ephx1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021983 VEGA Gene Model | MGI Sequence Detail 44695 C57BL/6J ±  kb
transcript OTTMUST00000052194 VEGA | MGI Sequence Detail 1741 Not Applicable 
polypeptide OTTMUSP00000024696 VEGA | MGI Sequence Detail 455 Not Applicable 

For the selected sequences
All sequences(74) RefSeq(2) UniProt(6)
Polymorphisms
All PCR and RFLP(3) : PCR(1) RFLP(2) SNPs within 2kb(523 from dbSNP Build 137)    SNPs within 2kb including multiple locations(525)
Protein-related
information
ResourceIDDescription
InterPro IPR000073 Alpha/beta hydrolase fold-1
InterPro IPR016292 Epoxide hydrolase
InterPro IPR000639 Epoxide hydrolase-like
InterPro IPR010497 Epoxide hydrolase, N-terminal
Protein Ontology PR:000007134 epoxide hydrolase 1
References
(Earliest) J:6369 Lyman SD, et al., Genetic polymorphism of microsomal epoxide hydrolase activity in the mouse. J Biol Chem. 1980 Sep 25;255(18):8650-4
(Latest) J:194239 Sirish P, et al., Unique mechanistic insights into the beneficial effects of soluble epoxide hydrolase inhibitors in the prevention of cardiac fibrosis. Proc Natl Acad Sci U S A. 2013 Apr 2;110(14):5618-23
All references(53)
Other
accession IDs
MGD-MRK-9563, MGD-MRK-9564, MGI:2138172

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory