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Ephx1
Gene Detail
 Symbol
Name
ID
Ephx1
epoxide hydrolase 1, microsomal
MGI:95405
Synonyms Eph1, Eph-1, mEH
Feature Type protein coding gene
Genetic Map
Chromosome 1
84.48 cM
Detailed Genetic Map ± 1 cM


Mapping data(13)
Sequence Map
Chr1:180976155-181020904 bp, - strand
From VEGA annotation of GRCm38

  44750 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:94  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: epoxide hydrolase
Gene Tree: Ephx1

Human
homologs
Human Homolog EPHX1, epoxide hydrolase 1, microsomal (xenobiotic)
NCBI Gene ID 2052
neXtProt AC  NX_P07099
Human Synonyms  EPHX, EPOX, HYL1, MEH
Human Chr (Location)  1q42.1; chr1:225810095-225845563 (+)  GRCh38
Disease Associations  (3) Diseases Associated with Human EPHX1
Mutations,
alleles, and
phenotypes
All mutations/alleles(14) : Gene trapped(8) Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele are highly resistant to DMBA-induced skin carcinogenesis.
 
Interactions
Ephx1 interacts with 29 markers (Mir1b, Mir134, Mir141, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (14 annotations)
Process aromatic compound catabolic process, cellular aromatic compound metabolic process, ...
Component endoplasmic reticulum, integral component of membrane, ...
Function catalytic activity, cis-stilbene-oxide hydrolase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (223)    Tissues (109)    Images (39)
Theiler Stages: 22, 23
Assay TypeResults
RNA in situ 223
cDNA source data(166)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(168) cDNA(167) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000021983 (Evidence)
Ensembl Gene ModelENSMUSG00000038776 (Evidence)
Entrez Gene13849 (Evidence)
UniGene9075
DFCITC1572693, TC1661957
DoTSDT.101266074, DT.55100658
EC3.3.2.9
Consensus CDS ProjectCCDS15579.1
International Mouse Knockout Project StatusEphx1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000021983 VEGA Gene Model | MGI Sequence Detail 44750 C57BL/6J ±  kb
transcript OTTMUST00000052194 VEGA | MGI Sequence Detail 1741 Not Applicable 
polypeptide OTTMUSP00000024696 VEGA | MGI Sequence Detail 455 Not Applicable 

For the selected sequences
All sequences(70) RefSeq(2) UniProt(6)
Polymorphisms All PCR and RFLP(3) : PCR(1) RFLP(2) SNPs within 2kb(524 from dbSNP Build 137)    SNPs within 2kb including multiple locations(526)
Protein-related
information
ResourceIDDescription
InterPro IPR000073 Alpha/beta hydrolase fold-1
InterPro IPR016292 Epoxide hydrolase
InterPro IPR000639 Epoxide hydrolase-like
InterPro IPR010497 Epoxide hydrolase, N-terminal
Protein Ontology PR:000007134 epoxide hydrolase 1
References (Earliest) J:6369 Lyman SD, et al., Genetic polymorphism of microsomal epoxide hydrolase activity in the mouse. J Biol Chem. 1980 Sep 25;255(18):8650-4
(Latest) J:194239 Sirish P, et al., Unique mechanistic insights into the beneficial effects of soluble epoxide hydrolase inhibitors in the prevention of cardiac fibrosis. Proc Natl Acad Sci U S A. 2013 Apr 2;110(14):5618-23
All references(55)
Other
accession IDs
MGD-MRK-9563, MGD-MRK-9564, MGI:2138172

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory