Ephx1
Gene Detail

Symbol Name ID

Ephx1 epoxide hydrolase 1, microsomal MGI:95405

Synonyms

Eph1, Eph-1, mEH

Feature Type

protein coding gene

Genetic Map

Chromosome 1

84.48 cM
Detailed Genetic Map ± 1 cM


Mapping data(13)

Sequence Map

Chr1:180976155-181020904 bp, - strand From VEGA annotation of GRCm38   44750 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:94  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: epoxide hydrolase
Gene Tree: Ephx1

Human homologs

Human Homolog		EPHX1, epoxide hydrolase 1, microsomal (xenobiotic)
NCBI Gene ID		2052
neXtProt AC		NX_P07099
Human Synonyms		EPHX, EPOX, HYL1, MEH
Human Chr (Location)		1q42.1; chr1:225997797-226033264 (+)  GRCh37.p10
Disease Associations		(3) Diseases Associated with Human EPHX1

Alleles and phenotypes

All alleles(14) : Targeted(6) Gene trapped(8)
 

Mice homozygous for a knock-out allele are highly resistant to DMBA-induced skin carcinogenesis.

 

Gene Ontology (GO) classifications

All GO classifications: (14 annotations)

Process	aromatic compound catabolic process, cellular aromatic compound metabolic process, ...
Component	endoplasmic reticulum, integral to membrane, ...
Function	catalytic activity, cis-stilbene-oxide hydrolase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (3 records)
Data Summary: Results (223)    Tissues (109)    Images (39)
Theiler Stages: 22, 23

Assay Type	Results
RNA in situ	223

cDNA source data(166)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(168) cDNA(167) Primer pair(1)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000021983 (Evidence)
Ensembl Gene Model	ENSMUSG00000038776 (Evidence)
Entrez Gene	13849 (Evidence)
UniGene	9075
DFCI	TC1572693, TC1661957
DoTS	DT.101266074, DT.55100658
EC	3.3.2.9
Consensus CDS Project	CCDS15579.1
International Mouse Knockout Project Status	Ephx1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000021983	VEGA Gene Model | MGI Sequence Detail	44750	C57BL/6J
transcript	OTTMUST00000052194	VEGA | MGI Sequence Detail	1741	Not Applicable
polypeptide	OTTMUSP00000024696	VEGA | MGI Sequence Detail	455	Not Applicable

All sequences(70) RefSeq(2) UniProt(6)

Polymorphisms

All PCR and RFLP(3) : PCR(1) RFLP(2) SNPs(261 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000073	Alpha/beta hydrolase fold-1
InterPro	IPR016292	Epoxide hydrolase
InterPro	IPR000639	Epoxide hydrolase-like
InterPro	IPR010497	Epoxide hydrolase, N-terminal
Protein Ontology	PR:000007134	epoxide hydrolase 1

References

(Earliest) J:6369 Lyman SD, et al., Genetic polymorphism of microsomal epoxide hydrolase activity in the mouse. J Biol Chem. 1980 Sep 25;255(18):8650-4
(Latest) J:181994 Kamileri I, et al., Defective transcription initiation causes postnatal growth failure in a mouse model of nucleotide excision repair (NER) progeria. Proc Natl Acad Sci U S A. 2012 Feb 21;109(8):2995-3000
All references(53)

Other accession IDs

MGD-MRK-9563, MGD-MRK-9564, MGI:2138172