Dvl1
Gene Detail

Symbol Name ID

Dvl1 dishevelled, dsh homolog 1 (Drosophila) MGI:94941

Feature Type

protein coding gene

Genetic Map

Chromosome 4

87.61 cM
Detailed Genetic Map ± 1 cM


Mapping data(17)

Sequence Map

Chr4:155847402-155859303 bp, + strand From VEGA annotation of GRCm38   11902 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:20926  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: segment polarity protein dishevelled homolog DVL
Gene Tree: Dvl1

Human homologs

Human Homolog		DVL1, dishevelled, dsh homolog 1 (Drosophila)
NCBI Gene ID		1855
neXtProt AC		NX_O14640
Human Synonyms		DVL, DVL1L1
Human Chr (Location)		1p36; chr1:1270658-1284492 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(6) : Targeted(6)
 

Homozygous targeted mutants are viable and fertile, but show a number of behavioral changes including deficient nest-building, less huddling contact during sleep, reduced subordinate responses, and other social interaction deficits.

 

Gene Ontology (GO) classifications

All GO classifications: (91 annotations)

Process	axon extension, axon guidance, ...
Component	axon, cell cortex, ...
Function	enzyme binding, frizzled binding, ...

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (19 records)
Data Summary: Results (267)    Tissues (126)    Images (47)
Theiler Stages: 1, 2, 3, 4, 5, 17, 19, 20, 22, 23, 24, 25, 26, 28

Assay Type	Results
Immunohistochemistry	1
RNA in situ	246
RT-PCR	20

cDNA source data(78)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(88) Genomic(3) cDNA(79) Primer pair(6)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000010890 (Evidence)
Ensembl Gene Model	ENSMUSG00000029071 (Evidence)
Entrez Gene	13542 (Evidence)
UniGene	3400
DFCI	TC1576035, TC1602954, TC1606858, TC1613797, TC1775336
DoTS	DT.489555, DT.87058099, DT.91414321, DT.94403322, DT.99857711
NIA Mouse Gene Index	U005222
PDB	1FSH, 2KAW, 1MC7, 3PZ8
Consensus CDS Project	CCDS19045.1
International Mouse Knockout Project Status	Dvl1

Sequences

Length	Strain/Species
genomic	OTTMUSG00000010890	VEGA Gene Model | MGI Sequence Detail	11902	C57BL/6J
transcript	OTTMUST00000025523	VEGA | MGI Sequence Detail	3358	Not Applicable
polypeptide	OTTMUSP00000011687	VEGA | MGI Sequence Detail	695	Not Applicable

All sequences(51) RefSeq(2) UniProt(3)

Polymorphisms

PCR(3) : SNPs(67 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000591	DEP domain
InterPro	IPR008340	Dishevelled-1
InterPro	IPR024580	Dishevelled C-terminal
InterPro	IPR008339	Dishevelled family
InterPro	IPR003351	Dishevelled protein domain
InterPro	IPR015506	Dishevelled-related protein
InterPro	IPR001158	DIX domain
InterPro	IPR001478	PDZ domain
InterPro	IPR011991	Winged helix-turn-helix transcription repressor DNA-binding
Protein Ontology	PR:000006765	segment polarity protein dishevelled DVL-1

References

(Earliest) J:2643 Beier DR, et al., Mapping genes in the mouse using single-strand conformation polymorphism analysis of recombinant inbred strains and interspecific crosses. Proc Natl Acad Sci U S A. 1992 Oct 1;89(19):9102-6
(Latest) J:188340 Berwick DC, et al., LRRK2 functions as a Wnt signaling scaffold, bridging cytosolic proteins and membrane-localized LRP6. Hum Mol Genet. 2012 Nov 15;21(22):4966-79
All references(102)

Other accession IDs

MGD-MRK-8919