About   Help   FAQ
Dvl1
Gene Detail
Symbol

Name
ID
Dvl1
dishevelled, dsh homolog 1 (Drosophila)
MGI:94941
Feature Type
protein coding gene
Genetic Map
Chromosome 4
87.61 cM
Detailed Genetic Map ± 1 cM


Mapping data(17)
Sequence Map
Chr4:155847402-155859303 bp, + strand
From VEGA annotation of GRCm38

  11902 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20926  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: segment polarity protein dishevelled homolog DVL
Gene Tree: Dvl1

Human
homologs
Human Homolog DVL1, dishevelled segment polarity protein 1
NCBI Gene ID 1855
neXtProt AC  NX_O14640
Human Synonyms  DVL, DVL1L1, DVL1P1
Human Chr (Location)  1p36; chr1:1335278-1349117 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous targeted mutants are viable and fertile, but show a number of behavioral changes including deficient nest-building, less huddling contact during sleep, reduced subordinate responses, and other social interaction deficits.
 
Interactions
Dvl1 interacts with 129 markers (Mir15a, Mir15b, Mir16-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (92 annotations)
Process axon extension, axon guidance, ...
Component axon, cell, ...
Function enzyme binding, frizzled binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (21 records)
Data Summary: Results (312)    Tissues (173)    Images (49)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 1
RNA in situ 295
RT-PCR 16
cDNA source data(80)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(90) Genomic(3) cDNA(81) Primer pair(6)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000010890 (Evidence)
Ensembl Gene ModelENSMUSG00000029071 (Evidence)
Entrez Gene13542 (Evidence)
UniGene3400
DFCITC1576035, TC1602954, TC1606858, TC1613797, TC1775336
DoTSDT.489555, DT.87058099, DT.91414321, DT.94403322, DT.99857711
NIA Mouse Gene IndexU005222
PDB1FSH, 2KAW, 1MC7, 3PZ8
Consensus CDS ProjectCCDS19045.1
International Mouse Knockout Project StatusDvl1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000010890 VEGA Gene Model | MGI Sequence Detail 11902 C57BL/6J ±  kb
transcript OTTMUST00000025523 VEGA | MGI Sequence Detail 3358 Not Applicable 
polypeptide OTTMUSP00000011687 VEGA | MGI Sequence Detail 695 Not Applicable 

For the selected sequences
All sequences(65) RefSeq(16) UniProt(3)
Polymorphisms
PCR(3) : SNPs within 2kb(120 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000591 DEP domain
InterPro IPR008340 Dishevelled-1
InterPro IPR024580 Dishevelled C-terminal
InterPro IPR008339 Dishevelled family
InterPro IPR003351 Dishevelled protein domain
InterPro IPR015506 Dishevelled-related protein
InterPro IPR001158 DIX domain
InterPro IPR001478 PDZ domain
InterPro IPR011991 Winged helix-turn-helix DNA-binding domain
Protein Ontology PR:000006765 segment polarity protein dishevelled homolog DVL-1
References
(Earliest) J:2643 Beier DR, et al., Mapping genes in the mouse using single-strand conformation polymorphism analysis of recombinant inbred strains and interspecific crosses. Proc Natl Acad Sci U S A. 1992 Oct 1;89(19):9102-6
(Latest) J:205269 Cui C, et al., Wdpcp, a PCP protein required for ciliogenesis, regulates directional cell migration and cell polarity by direct modulation of the actin cytoskeleton. PLoS Biol. 2013 Nov;11(11):e1001720
All references(110)
Other
accession IDs
MGD-MRK-8919

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
10/08/2014
MGI 5.20
The Jackson Laboratory