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Mammalian Phenotype Ontology Annotations
Query Results - Summary
Symbol
Name
ID 		Dvl1
dishevelled segment polarity protein 1
MGI:94941
25 phenotypes from multigenic genotypes
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Allelic Composition
Genetic Background		 Annotated Term Reference
\Dvl1tm1Awb/\Dvl1+
\Dvl2tm1Awb/\Dvl2+
involves: 129S6/SvEvTac 		normal hearing/vestibular/ear phenotype J:100861
\Dvl1tm1Awb/\Dvl1+
\Dvl2tm1Awb/\Dvl2tm1Awb
involves: 129S6/SvEvTac * LPT/LeJ 		neonatal lethality, incomplete penetrance J:108512
\Dvl1tm1Awb/\Dvl1+
\Dvl2tm1Awb/\Dvl2tm1Awb
\Vangl2Lp/\Vangl2+
involves: 129S6/SvEvTac * LPT/LeJ 		craniorachischisis J:108512
neonatal lethality, complete penetrance J:108512
\Dvl1tm1Awb/\Dvl1tm1Awb
\Dvl2tm1Awb/\Dvl2tm1Awb
either: 129S6/SvEvTac or (involves: 129S6/SvEvTac * NIH Swiss) 		abnormal organ of Corti morphology J:100861
abnormal orientation of outer hair cell stereociliary bundles J:100861
abnormal somite development J:79834
abnormal vertebrae morphology J:79834
double outlet right ventricle J:79834
exencephaly J:79834
increased cochlear hair cell number J:100861
open neural tube J:79834
persistent truncus arteriosus J:79834
prenatal lethality, complete penetrance J:79834
rib fusion J:79834
transposition of great arteries J:79834
\Dvl1tm1Awb/\Dvl1tm1Awb
\Dvl2tm1Awb/\Dvl2tm1Awb
involves: 129S6/SvEvTac 		abnormal cochlear inner hair cell morphology J:108512
abnormal embryo development J:108512
abnormal notochord morphology J:108512
abnormal orientation of outer hair cell stereociliary bundles J:108512
enlarged floor plate J:108512
open neural tube J:108512
\Dvl1tm1Awb/\Dvl1tm1Awb
\Dvl2tm1Awb/\Dvl2tm1Awb
involves: 129S6/SvEvTac * C57BL/6 		normal hearing/vestibular/ear phenotype J:108512
open neural tube J:108512
premature death J:108512
\Dvl1tm1Awb/\Dvl1tm1Awb
\Dvl2tm1Awb/\Dvl2tm1Awb
\Tg(Dvl2*/EGFP)3Awb/?
involves: 129S6/SvEvTac 		normal nervous system phenotype J:108512
\Dvl1tm1Awb/\Dvl1tm1Awb
\Dvl2tm1Awb/\Dvl2tm1Awb
\Tg(Dvl2*/EGFP)4Awb/?
involves: 129S6/SvEvTac 		craniorachischisis J:108512
\Dvl1tm1Awb/\Dvl1tm1Awb
\Dvl2tm1Awb/\Dvl2tm1Awb
\Tg(Dvl2*K446M/EGFP)5Awb/?
involves: 129S6/SvEvTac 		abnormal cochlea morphology J:108512
abnormal orientation of outer hair cell stereociliary bundles J:108512
craniorachischisis J:108512
\Dvl1tm1Awb/\Dvl1tm1Awb
\Dvl2tm1Awb/\Dvl2tm1Awb
\Tg(Dvl2/EGFP)1Awb/?
involves: 129S6/SvEvTac 		no abnormal phenotype detected J:108512
\Dvl1tm1Awb/\Dvl1tm1Awb
\Dvl2tm1Awb/\Dvl2tm1Awb
\Tg(Dvl2/EGFP)2Awb/?
involves: 129S6/SvEvTac 		no abnormal phenotype detected J:108512
\Dvl1tm1Awb/\Dvl1tm1Awb
\Dvl2tm1Awb/\Dvl2tm1Awb
\Vangl2Lp/\Vangl2Lp
involves: 129S6/SvEvTac * LPT/LeJ 		craniorachischisis J:108512
\Dvl1tm1Awb/\Dvl1tm1Awb
\Dvl3tm1Awb/\Dvl3tm1Awb
involves: 129S6/SvEvTac * Black Swiss 		lethality throughout fetal growth and development, complete penetrance J:142392
normal nervous system phenotype J:142392
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory