Tg(Dvl2*K446M/EGFP)5Awb
Transgene Detail

Summary

• Symbol: Tg(Dvl2*K446M/EGFP)5Awb
• Name: transgene insertion 5, Anthony Wynshaw-Boris
• MGI ID: MGI:3715920
• Synonyms: dsh1-EGFP
• Transgene: Tg(Dvl2*K446M/EGFP)5Awb Location: unknown
• Alliance: Tg(Dvl2*K446M/EGFP)5Awb page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Inserted expressed sequence)
• Mutation: Insertion
• Tg(Dvl2*K446M/EGFP)5Awb expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Dvl2 (MGI:106613)	Transgene codes for a protein with a lysine to methionine mutation.

• Mutation details: The Dvl2 promoter drives the expression of Dvl2 with EGFP fused downstream of the 15th exon with a LoxP site inserted 3' of Acadvl, and a point mutation introduced at the codon 446. This mutation is predicted to alter lysine 446 to methionine in the encoded protein. The point mutation is identical to a varaint identified in Drosophila that abolishes planar cell polarity function. (J:108512)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:108512 Wang J, et al., Dishevelled genes mediate a conserved mammalian PCP pathway to regulate convergent extension during neurulation. Development. 2006 May;133(9):1767-78
• All: 2 reference(s)