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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(Dvl2*K446M/EGFP)5Awb
transgene insertion 5, Anthony Wynshaw-Boris
MGI:3715920
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Dvl1tm1Awb/Dvl1tm1Awb
Dvl2tm1Awb/Dvl2tm1Awb
Tg(Dvl2*K446M/EGFP)5Awb/? 		involves: 129S6/SvEvTac MGI:3715993


Genotype
MGI:3715993
cx1
Allelic
Composition		 Dvl1tm1Awb/Dvl1tm1Awb
Dvl2tm1Awb/Dvl2tm1Awb
Tg(Dvl2*K446M/EGFP)5Awb/?
Genetic
Background		 involves: 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dvl1tm1Awb mutation (2 available); any Dvl1 mutation (31 available)
Dvl2tm1Awb mutation (1 available); any Dvl2 mutation (33 available)
Tg(Dvl2*K446M/EGFP)5Awb mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
craniorachischisis ( J:108512 )
• seen in all mice at E9.5
abnormal orientation of outer hair cell stereociliary bundles ( J:108512 )
• at P0, the stereociliary bundle orientation in the cochlea is disrupted and a less recognizable form of stereocilia is observed

hearing/vestibular/ear
abnormal cochlea morphology ( J:108512 )
• cochlea are wider and shorter
abnormal orientation of outer hair cell stereociliary bundles ( J:108512 )
• at P0, the stereociliary bundle orientation in the cochlea is disrupted and a less recognizable form of stereocilia is observed

embryo
craniorachischisis ( J:108512 )
• seen in all mice at E9.5




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory