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Drd3
Gene Detail
Symbol

Name
ID
Drd3
dopamine receptor D3
MGI:94925
Synonyms
D3R, D3 receptor
Feature Type
protein coding gene
Genetic Map
Chromosome 16
28.44 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr16:43762221-43822932 bp, + strand
From Ensembl annotation of GRCm38

  60712 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:623  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

HCOP human homology predictions: DRD3
Protein SuperFamily: D2-like dopamine receptor
Gene Tree: Drd3

Human
homologs
DRD3, dopamine receptor D3
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 1814
neXtProt AC: NX_P35462

Human Synonyms: D3DR, ETM1, FET1

Human Chr (Location): 3q13.3; chr3:114127797-114199407 (-)  GRCh38.p2

Disease Associations: (2) Diseases Associated with Human DRD3

Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Gene trapped(3) Targeted(4)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygous mutants show exploratory hyperactivity and increased locomotion and rearing behavior, with heterozygous mice displaying similar, but less pronounced, behaviors.
 
Interactions
Drd3 interacts with 27 markers (Mir34a, Mir34b, Mir34c, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (6 records)
Data Summary: Results (135)    Tissues (68)    Images (15)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 43
RT-PCR 92
cDNA source data(6)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: ZFIN drd3    NEW 
Molecular
reagents
All nucleic(15) Genomic(8) cDNA(6) Primer pair(1)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000022705 (Evidence)
Entrez Gene 13490 (Evidence)
UniGene 439735
DoTS DT.87039443
NIA Mouse Gene Index U017148
Consensus CDS Project CCDS28179.1
International Mouse Phenotyping Consortium Status Drd3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000022705 Ensembl Gene Model | MGI Sequence Detail 60712 C57BL/6J ±  kb
transcript ENSMUST00000023390 Ensembl | MGI Sequence Detail 1455 Not Applicable 
polypeptide ENSMUSP00000023390 Ensembl | MGI Sequence Detail 446 Not Applicable 

For the selected sequences
All sequences(15) RefSeq(4) UniProt(2)
Polymorphisms
SNPs within 2kb(327 from dbSNP Build 137)    SNPs within 2kb including multiple locations(331)
Protein-related
information
ResourceIDDescription
InterPro IPR001620 Dopamine D3 receptor
InterPro IPR000929 Dopamine receptor family
InterPro IPR017452 GPCR, rhodopsin-like, 7TM
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
Protein Ontology PR:000001178 D(3) dopamine receptor
References
(Earliest) J:14384 Copeland NG, et al., A genetic linkage map of the mouse: current applications and future prospects [see comments]. Science. 1993 Oct 1;262(5130):57-66
(Latest) J:219353 Castro-Hernandez J, et al., Prolonged treatment with pramipexole promotes physical interaction of striatal dopamine D3 autoreceptors with dopamine transporters to reduce dopamine uptake. Neurobiol Dis. 2015 Feb;74:325-35
All references(117)
Other
accession IDs
MGD-MRK-8898

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory