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Drd3
Gene Detail
Symbol

Name
ID
Drd3
dopamine receptor D3
MGI:94925
Synonyms
D3R, D3 receptor
Feature Type
protein coding gene
Genetic Map
Chromosome 16
28.44 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr16:43762242-43822839 bp, + strand
From NCBI annotation of GRCm38

  60598 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:623  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: D2-like dopamine receptor
Gene Tree: Drd3

Human
homologs
Human Homolog DRD3, dopamine receptor D3
NCBI Gene ID 1814
neXtProt AC  NX_P35462
Human Synonyms  D3DR, ETM1, FET1
Human Chr (Location)  3q13.3; chr3:114128710-114199407 (-)  GRCh38
Disease Associations  (2) Diseases Associated with Human DRD3
Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Gene trapped(3) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutants show exploratory hyperactivity and increased locomotion and rearing behavior, with heterozygous mice displaying similar, but less pronounced, behaviors.
 
Interactions
Drd3 interacts with 28 markers (Mir34a, Mir34b, Mir34c, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (6 records)
Data Summary: Results (135)    Tissues (68)    Images (15)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 43
RT-PCR 92
cDNA source data(6)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(15) Genomic(8) cDNA(6) Primer pair(1)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000022705 (Evidence)
Entrez Gene13490 (Evidence)
UniGene439735
DoTSDT.87039443
NIA Mouse Gene IndexU017148
Consensus CDS ProjectCCDS28179.1
International Mouse Knockout Project StatusDrd3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 13490 NCBI Gene Model | MGI Sequence Detail 60598 C57BL/6J ±  kb
transcript NM_007877 RefSeq | MGI Sequence Detail 1341 BALB/c 
polypeptide P30728 UniProt | EBI | MGI Sequence Detail 446 Not Applicable 

For the selected sequences
All sequences(16) RefSeq(4) UniProt(3)
Polymorphisms
SNPs within 2kb(327 from dbSNP Build 137)    SNPs within 2kb including multiple locations(331)
Protein-related
information
ResourceIDDescription
InterPro IPR001620 Dopamine D3 receptor
InterPro IPR000929 Dopamine receptor family
InterPro IPR017452 GPCR, rhodopsin-like, 7TM
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
Protein Ontology PR:000001178 D(3) dopamine receptor
Graphical View of Protein Domain Structure
References
(Earliest) J:14384 Copeland NG, et al., A genetic linkage map of the mouse: current applications and future prospects [see comments]. Science. 1993 Oct 1;262(5130):57-66
(Latest) J:207038 Castorina A, et al., Dopamine D3 receptor deletion increases tissue plasminogen activator (tPA) activity in prefrontal cortex and hippocampus. Neuroscience. 2013 Oct 10;250:546-56
All references(114)
Other
accession IDs
MGD-MRK-8898

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
10/21/2014
MGI 5.20
The Jackson Laboratory