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Drd3 Gene Detail
Summary
  • Symbol
    Drd3
  • Name
    dopamine receptor D3
  • Synonyms
    D3R, D3 receptor
  • Feature Type
    protein coding gene
  • IDs
    MGI:94925
    NCBI Gene: 13490
  • Gene Overview
    MyGene.info: DRD3
Location & Maps
more
  • Sequence Map
    Chr16:43762221-43822932 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      60712 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 16, 28.44 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    DRD3, dopamine receptor D3
  • Vertebrate Orthologs
    8
  • Human Ortholog
    DRD3, dopamine receptor D3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    D3DR, ETM1, FET1
  • Links
    NCBI Gene ID: 1814
    neXtProt AC: NX_P35462

  • Chr Location
    3q13.3; chr3:114127797-114199407 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    2 with human DRD3 associations

Human Disease Mouse Models
       Schizophrenia; SCZD   OMIM: 181500
Tremor, Hereditary Essential, 1; ETM1   OMIM: 190300
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    35 phenotypes from 3 alleles in 8 genetic backgrounds
    24 phenotypes from multigenic genotypes
    71 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    8
  • Gene trapped
    3
  • Targeted
    4
  • Transgenic
    1
  • Incidental Mutations
Homozygous mutants show exploratory hyperactivity and increased locomotion and rearing behavior, with heterozygous mice displaying similar, but less pronounced, behaviors.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000022705 Ensembl Gene Model | MGI Sequence Detail 60712 C57BL/6J ±  kb
transcript ENSMUST00000023390 Ensembl | MGI Sequence Detail 1455 Not Applicable  
polypeptide ENSMUSP00000023390 Ensembl | MGI Sequence Detail 446 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    326 from dbSNP Build 142
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000001178 D(3) dopamine receptor
  • InterPro Domains
    IPR001620 Dopamine D3 receptor
    IPR000929 Dopamine receptor family
    IPR017452 GPCR, rhodopsin-like, 7TM
    IPR000276 G protein-coupled receptor, rhodopsin-like
Molecular
Reagents
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  • All nucleic 15
    Genomic 8
    cDNA 6
    Primer pair 1

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-8898
References
more
  • Summaries
    All 118
    Developmental Gene Expression 7
    Gene Ontology 33
    Phenotypes 71
  • Earliest
    J:14384 Copeland NG, et al., A genetic linkage map of the mouse: current applications and future prospects [see comments]. Science. 1993 Oct 1;262(5130):57-66
  • Latest
    J:231175 Marzagalli R, et al., Genetic blockade of the dopamine D3 receptor enhances hippocampal expression of PACAP and receptors and alters their cortical distribution. Neuroscience. 2016 Mar 1;316:279-95

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory