Phenotypes Associated with This Genotype

Genotype
MGI:4839954

• Allelic Composition: Drd3^tm1Dac/Drd3^tm1Dac
• Genetic Background: B6.129S4-Drd3^tm1Dac/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

decreased anxiety-related response ( J:102600 )

• mice exhibit increased entry into open arms in an elevated plus maze compared with wild-type mice

abnormal reflex ( J:96803 )

• mice exhibit more large-reflex amplitudes for both monosynaptic 'stretch' reflex (MSR) and longer-latency reflex responses compared with wild-type mice

• mice treated with 1 or 5 um dopamine exhibit led to an increase in MSR amplitude and reflex strength unlike in similarly treated wild-type mice

• mice treated with a D3 receptor antagonist do not exhibit an increase in monosynaptic reflex strength unlike in similarly treated wild-type mice

• mice treated with D2 receptor agonists fail to exhibit a decrease in monosynaptic reflex strength compared with similarly treated wild-type mice

• mice treated with pergolide do not exhibit a difference in monosynaptic and longer-latency reflex amplitudes unlike in similarly treated wild-type mice

• mice treated with GR 103691 exhibit shorter monosynaptic than longer-latency reflex amplitude unlike in wild-type mice

abnormal motor coordination/balance ( J:102600 )

• on day 2, mice exhibit improved performance on a rotarod compared with wild-type mice

increased vertical activity ( J:102600 )

increased locomotor activity ( J:102600 )

• in an open field compared with wild-type mice

homeostasis/metabolism

abnormal physiological response to xenobiotic ( J:96803 )

• mice treated with a D3 receptor antagonist do not exhibit an increase in monosynaptic reflex strength unlike in similarly treated wild-type mice

• mice treated with D2 receptor agonists fail to exhibit a decrease in monosynaptic reflex strength compared with similarly treated wild-type mice

• mice treated with pergolide do not exhibit a difference in monosynaptic and longer-latency reflex amplitudes unlike in similarly treated wild-type mice

• mice treated with GR 103691 exhibit shorter monosynaptic than longer-latency reflex amplitude unlike in wild-type mice

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
restless legs syndrome		DOID:0050425	OMIM:PS102300	J:96803