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Dnmt1
Gene Detail
Symbol

Name
ID
Dnmt1
DNA methyltransferase (cytosine-5) 1
MGI:94912
Synonyms
Cxxc9, Dnmt1o, MommeD2, MTase
Feature Type
protein coding gene
Genetic Map
Chromosome 9
7.66 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr9:20907206-20959888 bp, - strand
From Ensembl annotation of GRCm38

  52683 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:124071  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: DNA (cytosine-5)-methyltransferase 1, DNMT1 type
Gene Tree: Dnmt1

Human
homologs
Human Homolog DNMT1, DNA (cytosine-5-)-methyltransferase 1
NCBI Gene ID 1786
neXtProt AC  NX_P26358
Human Synonyms  ADCADN, AIM, CXXC9, DNMT, HSN1E, MCMT
Human Chr (Location)  19p13.2; chr19:10133345-10195079 (-)  GRCh38
Disease Associations  (2) Diseases Associated with Human DNMT1
Mutations,
alleles, and
phenotypes
All mutations/alleles(127) : Chemically induced (ENU)(1) Gene trapped(110) Targeted(16)
Incidental mutations (data from Mutagenetix , APF )
 
Mutations causing partial or severe loss of function were homozygous lethal by embryonic day 9.5, with lack of appropriate genomic imprinting observed at several loci.
 
Interactions
Dnmt1 interacts with 101 markers (Mir24-1, Mir24-2, Mir27b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (70 annotations)
Process C-5 methylation of cytosine, cellular response to amino acid stimulus, ...
Component cytoplasm, heterochromatin, ...
Function catalytic activity, chromatin binding, ...
External Resources: FuncBase
Expression
Literature Summary: (47 records)
Data Summary: Results (990)    Tissues (751)    Images (50)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 7
RNA in situ 873
Northern blot 21
Western blot 16
RT-PCR 73
cDNA source data(35)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(49) Genomic(2) cDNA(35) Primer pair(11) Other(1)
Microarray probesets(5)
Other database
links
Ensembl Gene ModelENSMUSG00000004099 (Evidence)
Entrez Gene13433 (Evidence)
DFCITC1571953, TC1591743, TC1613614, TC1754229
DoTSDT.101394830, DT.110588447, DT.529886, DT.94310775, DT.94349199, DT.94349200
NIA Mouse Gene IndexU030563
EC2.1.1.37
PDB3AV4, 3AV5, 3AV6, 3PT6, 3PT9, 4DA4
Consensus CDS ProjectCCDS57653.1, CCDS57654.1, CCDS57655.1
International Mouse Knockout Project StatusDnmt1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000004099 Ensembl Gene Model | MGI Sequence Detail 52683 C57BL/6J ±  kb
transcript ENSMUST00000004202 Ensembl | MGI Sequence Detail 5370 Not Applicable 
polypeptide ENSMUSP00000004202 Ensembl | MGI Sequence Detail 1620 Not Applicable 

For the selected sequences
All sequences(72) RefSeq(16) UniProt(13)
Polymorphisms
SNPs within 2kb(367 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001025 Bromo adjacent homology (BAH) domain
InterPro IPR001525 C-5 cytosine methyltransferase
InterPro IPR010506 DMAP1-binding
InterPro IPR017198 DNA (cytosine-5)-methyltransferase 1, eukaryote
InterPro IPR022702 DNA (cytosine-5)-methyltransferase 1, replication foci domain
InterPro IPR018117 DNA methylase, C-5 cytosine-specific, active site
InterPro IPR002857 Zinc finger, CXXC-type
Protein Ontology PR:000006606 DNA (cytosine-5)-methyltransferase 1
References
(Earliest) J:9536 Bestor T, et al., Cloning and sequencing of a cDNA encoding DNA methyltransferase of mouse cells. The carboxyl-terminal domain of the mammalian enzymes is related to bacterial restriction methyltransferases. J Mol Biol. 1988 Oct 20;203(4):971-83
(Latest) J:214821 Bhatnagar S, et al., Genetic and pharmacological reactivation of the mammalian inactive X chromosome. Proc Natl Acad Sci U S A. 2014 Sep 2;111(35):12591-8
All references(221)
Other
accession IDs
MGD-MRK-12204, MGD-MRK-12206, MGD-MRK-8877, MGI:3586536

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
11/18/2014
MGI 5.20
The Jackson Laboratory