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Dnmt1 Gene Detail
Summary
  • Symbol
    Dnmt1
  • Name
    DNA methyltransferase (cytosine-5) 1
  • Synonyms
    Cxxc9, Dnmt1o, MommeD2, MTase
  • Feature Type
    protein coding gene
  • IDs
    MGI:94912
    NCBI Gene: 13433
  • Gene Overview
    MyGene.info: DNMT1
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr9:20907209-20959888 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      52680 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 7.66 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    DNMT1, DNA methyltransferase 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    DNMT1, DNA methyltransferase 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ADCADN, AIM, CXXC9, DNMT, HSN1E, MCMT, m.HsaI
  • Links
    NCBI Gene ID: 1786
    neXtProt AC: NX_P26358
    UniProt: P26358

  • Chr Location
    19p13.2; chr19:10133344-10195135 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    2 with human DNMT1 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    25 phenotypes from 10 alleles in 7 genetic backgrounds
    18 phenotypes from multigenic genotypes
    118 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mutations causing partial or severe loss of function were homozygous lethal by embryonic day 9.5, with lack of appropriate genomic imprinting observed at several loci.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000004099 Ensembl Gene Model | MGI Sequence Detail 52680 C57BL/6J ±  kb
    transcript ENSMUST00000004202 Ensembl | MGI Sequence Detail 5367 Not Applicable  
    polypeptide ENSMUSP00000004202 Ensembl | MGI Sequence Detail 1620 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      367 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 51
      Genomic 2
      cDNA 36
      Primer pair 12
      Other 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-12204, MGD-MRK-12206, MGD-MRK-8877, MGI:3586536
    References
    more
    • Summaries
      All 286
      Developmental Gene Expression 57
      Gene Ontology 27
      Phenotypes 118
    • Earliest
      J:8054 Markovac J, et al., A component of genetic variation among mice in activity of transmembrane methyltransferase I determined by the H-2 region. Biochem Pharmacol. 1985 Oct 1;34(19):3421-5
    • Latest
      J:259618 Hatazawa Y, et al., Reduced Dnmt3a increases Gdf5 expression with suppressed satellite cell differentiation and impaired skeletal muscle regeneration. FASEB J. 2018 Mar;32(3):1452-1467

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    05/15/2018
    MGI 6.12
    The Jackson Laboratory