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Dnmt1 Gene Detail
Summary
  • Symbol
    Dnmt1
  • Name
    DNA methyltransferase (cytosine-5) 1
  • Synonyms
    Cxxc9, Dnmt1o, MommeD2, MTase
  • Feature Type
    protein coding gene
  • IDs
    MGI:94912
    NCBI Gene: 13433
  • Gene Overview
    MyGene.info: DNMT1
Location & Maps
more
  • Sequence Map
    Chr9:20907206-20959888 bp, - strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      52683 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 7.66 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    DNMT1, DNA (cytosine-5-)-methyltransferase 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    DNMT1, DNA (cytosine-5-)-methyltransferase 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    ADCADN, AIM, CXXC9, DNMT, HSN1E, MCMT, m.HsaI
  • Links
    NCBI Gene ID: 1786
    neXtProt AC: NX_P26358

  • Chr Location
    19p13.2; chr19:10133345-10195079 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    2 with human DNMT1 associations

Human Disease Mouse Models
       Cerebellar Ataxia, Deafness, and Narcolepsy, Autosomal Dominant; ADCADN   OMIM: 604121
Neuropathy, Hereditary Sensory, Type IE; HSN1E   OMIM: 614116
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    25 phenotypes from 10 alleles in 7 genetic backgrounds
    18 phenotypes from multigenic genotypes
    103 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    135
  • Chemically induced (ENU)
    2
  • Gene trapped
    110
  • Targeted
    23
  • Incidental Mutations
Mutations causing partial or severe loss of function were homozygous lethal by embryonic day 9.5, with lack of appropriate genomic imprinting observed at several loci.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000004099 Ensembl Gene Model | MGI Sequence Detail 52683 C57BL/6J ±  kb
transcript ENSMUST00000004202 Ensembl | MGI Sequence Detail 5370 Not Applicable  
polypeptide ENSMUSP00000004202 Ensembl | MGI Sequence Detail 1620 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    367 from dbSNP Build 142
Protein
Information
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Molecular
Reagents
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  • All nucleic 49
    Genomic 2
    cDNA 35
    Primer pair 11
    Other 1

    Microarray probesets 5
Other
Accession IDs
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MGD-MRK-12204, MGD-MRK-12206, MGD-MRK-8877, MGI:3586536
References
more
  • Summaries
    All 233
    Developmental Gene Expression 51
    Gene Ontology 27
    Phenotypes 103
  • Earliest
    J:9536 Bestor T, et al., Cloning and sequencing of a cDNA encoding DNA methyltransferase of mouse cells. The carboxyl-terminal domain of the mammalian enzymes is related to bacterial restriction methyltransferases. J Mol Biol. 1988 Oct 20;203(4):971-83
  • Latest
    J:230655 Elliott EN, et al., The 'de novo' DNA methyltransferase Dnmt3b compensates the Dnmt1-deficient intestinal epithelium. Elife. 2016;5

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory