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Dnmt1 Gene Detail
Summary
  • Symbol
    Dnmt1
  • Name
    DNA methyltransferase (cytosine-5) 1
  • Synonyms
    Cxxc9, Dnmt1o, MommeD2, MTase
  • Feature Type
    protein coding gene
  • IDs
    MGI:94912
    NCBI Gene: 13433
  • Gene Overview
    MyGene.info: DNMT1
Location & Maps
more
  • Sequence Map
    Chr9:20907206-20959888 bp, - strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      52683 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 7.66 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    DNMT1, DNA methyltransferase 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    DNMT1, DNA methyltransferase 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ADCADN, AIM, CXXC9, DNMT, HSN1E, MCMT, m.HsaI
  • Links
    NCBI Gene ID: 1786
    neXtProt AC: NX_P26358
    UniProt: P26358

  • Chr Location
    19p13.2; chr19:10133344-10195135 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    2 with human DNMT1 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    25 phenotypes from 10 alleles in 7 genetic backgrounds
    18 phenotypes from multigenic genotypes
    110 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mutations causing partial or severe loss of function were homozygous lethal by embryonic day 9.5, with lack of appropriate genomic imprinting observed at several loci.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 13433 NCBI Gene Model | MGI Sequence Detail 52683 C57BL/6J ±  kb
transcript NM_001199433 RefSeq | MGI Sequence Detail 5876 C57BL/6  
polypeptide P13864 UniProt | EBI | MGI Sequence Detail 1620 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    367 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 51
    Genomic 2
    cDNA 36
    Primer pair 12
    Other 1

    Microarray probesets 5
Other
Accession IDs
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MGD-MRK-12204, MGD-MRK-12206, MGD-MRK-8877, MGI:3586536
References
more
  • Summaries
    All 243
    Developmental Gene Expression 54
    Gene Ontology 26
    Phenotypes 110
  • Earliest
    J:9536 Bestor T, et al., Cloning and sequencing of a cDNA encoding DNA methyltransferase of mouse cells. The carboxyl-terminal domain of the mammalian enzymes is related to bacterial restriction methyltransferases. J Mol Biol. 1988 Oct 20;203(4):971-83
  • Latest
    J:240642 Cooper S, et al., Jarid2 binds mono-ubiquitylated H2A lysine 119 to mediate crosstalk between Polycomb complexes PRC1 and PRC2. Nat Commun. 2016 Nov 28;7:13661

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/20/2017
MGI 6.10
The Jackson Laboratory