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Dnmt1 Gene Detail
Summary
  • Symbol
    Dnmt1
  • Name
    DNA methyltransferase (cytosine-5) 1
  • Synonyms
    Cxxc9, Dnmt1o, MommeD2, MTase
  • Feature Type
    protein coding gene
  • IDs
    MGI:94912
    NCBI Gene: 13433
  • Gene Overview
    MyGene.info: DNMT1
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:20907209-20959888 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 7.66 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    367 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_94912
protein coding gene Chr9:20907206-20959888 (-)
129S1/SvImJ MGP_129S1SvImJ_G0034432
protein coding gene Chr9:18075760-18121308 (-)
A/J MGP_AJ_G0034410
protein coding gene Chr9:17781831-17827785 (-)
AKR/J MGP_AKRJ_G0034337
protein coding gene Chr9:18100683-18146257 (-)
BALB/cJ MGP_BALBcJ_G0034401
protein coding gene Chr9:17675242-17725149 (-)
C3H/HeJ MGP_C3HHeJ_G0034113
protein coding gene Chr9:18412376-18457957 (-)
C57BL/6NJ MGP_C57BL6NJ_G0034922
protein coding gene Chr9:18790327-18849957 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0031852
protein coding gene Chr9:16907026-16960331 (-)
CAST/EiJ MGP_CASTEiJ_G0033436
protein coding gene Chr9:18234977-18280737 (-)
CBA/J MGP_CBAJ_G0034086
protein coding gene Chr9:19514633-19563382 (-)
DBA/2J MGP_DBA2J_G0034245
protein coding gene Chr9:17766376-17811961 (-)
FVB/NJ MGP_FVBNJ_G0034188
protein coding gene Chr9:17272595-17318199 (-)
LP/J MGP_LPJ_G0034330
protein coding gene Chr9:18256694-18302271 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0034231
protein coding gene Chr9:21138536-21186436 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0034942
protein coding gene Chr9:18058514-18103763 (-)
PWK/PhJ MGP_PWKPhJ_G0033142
protein coding gene Chr9:17732030-17777825 (-)
SPRET/EiJ MGP_SPRETEiJ_G0032976
protein coding gene Chr9:18100971-18146627 (-)
WSB/EiJ MGP_WSBEiJ_G0033551
protein coding gene Chr9:17782261-17828760 (-)



Homology
more
  • Human Ortholog
    DNMT1, DNA methyltransferase 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    DNMT1, DNA methyltransferase 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    ADCADN, AIM, CXXC9, DNMT, HSN1E, MCMT, m.HsaI
  • Links
    NCBI Gene ID: 1786
    neXtProt AC: NX_P26358
    UniProt: P26358

  • Chr Location
    19p13.2; chr19:10133344-10195135 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    2 with human DNMT1 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    25 phenotypes from 10 alleles in 7 genetic backgrounds
    18 phenotypes from multigenic genotypes
    134 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mutations causing partial or severe loss of function were homozygous lethal by embryonic day 9.5, with lack of appropriate genomic imprinting observed at several loci.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000004099 Ensembl Gene Model | MGI Sequence Detail 52680 C57BL/6J ±  kb
    transcript ENSMUST00000004202 Ensembl | MGI Sequence Detail 5367 Not Applicable  
    polypeptide ENSMUSP00000004202 Ensembl | MGI Sequence Detail 1620 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 53
      Genomic 2
      cDNA 37
      Primer pair 13
      Other 1

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-12204, MGD-MRK-12206, MGD-MRK-8877, MGI:3586536
    References
    more
    • Summaries
      All 310
      Developmental Gene Expression 68
      Gene Ontology 28
      Phenotypes 134
    • Earliest
      J:8054 Markovac J, et al., A component of genetic variation among mice in activity of transmembrane methyltransferase I determined by the H-2 region. Biochem Pharmacol. 1985 Oct 1;34(19):3421-5
    • Latest
      J:279216 Sun L, et al., Contribution of DNMT1 to Neuropathic Pain Genesis Partially through Epigenetically Repressing Kcna2 in Primary Afferent Neurons. J Neurosci. 2019 Aug 14;39(33):6595-6607

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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    Funding Information
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    last database update
    10/15/2019
    MGI 6.14
    The Jackson Laboratory