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Dnmt1
Gene Detail
 Symbol
Name
ID
Dnmt1
DNA methyltransferase (cytosine-5) 1
MGI:94912
Synonyms Cxxc9, Dnmt1o, MommeD2, MTase
Feature Type protein coding gene
Genetic Map
Chromosome 9
7.66 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr9:20907206-20959888 bp, - strand
From NCBI annotation of GRCm38

  52683 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:124071  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: DNA (cytosine-5)-methyltransferase 1, DNMT1 type
Gene Tree: Dnmt1

Human
homologs
Human Homolog DNMT1, DNA (cytosine-5-)-methyltransferase 1
NCBI Gene ID 1786
neXtProt AC  NX_P26358
Human Synonyms  ADCADN, AIM, CXXC9, DNMT, HSN1E, MCMT
Human Chr (Location)  19p13.2; chr19:10133345-10195079 (-)  GRCh38
Disease Associations  (2) Diseases Associated with Human DNMT1
Mutations,
alleles, and
phenotypes
All mutations/alleles(127) : Chemically induced (ENU)(1) Gene trapped(110) Targeted(16)
Incidental mutations (data from Mutagenetix , APF )
 
Mutations causing partial or severe loss of function were homozygous lethal by embryonic day 9.5, with lack of appropriate genomic imprinting observed at several loci.
 
Interactions
Dnmt1 interacts with 101 markers (Mir24-1, Mir24-2, Mir27b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (64 annotations)
Process C-5 methylation of cytosine, cellular response to amino acid stimulus, ...
Component centromeric heterochromatin, cytoplasm, ...
Function catalytic activity, chromatin binding, ...
External Resources: FuncBase
Expression
Literature Summary: (46 records)
Data Summary: Results (992)    Tissues (750)    Images (50)
Theiler Stages: 1, 2, 3, 4, 5, 11, 13, 15, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28
Assay TypeResults
Immunohistochemistry 7
RNA in situ 875
Northern blot 21
Western blot 16
RT-PCR 73
cDNA source data(35)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(49) Genomic(2) cDNA(35) Primer pair(11) Other(1)
Microarray probesets(5)
Other database
links
Ensembl Gene ModelENSMUSG00000004099 (Evidence)
Entrez Gene13433 (Evidence)
DFCITC1571953, TC1591743, TC1613614, TC1754229
DoTSDT.101394830, DT.110588447, DT.529886, DT.94310775, DT.94349199, DT.94349200
NIA Mouse Gene IndexU030563
EC2.1.1.37
PDB3AV4, 3AV5, 3AV6, 3PT6, 3PT9, 4DA4
Consensus CDS ProjectCCDS57653.1, CCDS57654.1, CCDS57655.1
International Mouse Knockout Project StatusDnmt1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 13433 NCBI Gene Model | MGI Sequence Detail 52683 C57BL/6J ±  kb
transcript NM_001199433 RefSeq | MGI Sequence Detail 5876 C57BL/6 
polypeptide P13864 UniProt | EBI | MGI Sequence Detail 1620 Not Applicable 

For the selected sequences
All sequences(66) RefSeq(16) UniProt(7)
Polymorphisms SNPs within 2kb(367 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001025 Bromo adjacent homology (BAH) domain
InterPro IPR001525 C-5 cytosine methyltransferase
InterPro IPR010506 DMAP1-binding
InterPro IPR017198 DNA (cytosine-5)-methyltransferase 1, eukaryote
InterPro IPR022702 DNA (cytosine-5)-methyltransferase 1, replication foci domain
InterPro IPR018117 DNA methylase, C-5 cytosine-specific, active site
InterPro IPR002857 Zinc finger, CXXC-type
Protein Ontology PR:000006606 DNA (cytosine-5)-methyltransferase 1
Graphical View of Protein Domain Structure
References (Earliest) J:9536 Bestor T, et al., Cloning and sequencing of a cDNA encoding DNA methyltransferase of mouse cells. The carboxyl-terminal domain of the mammalian enzymes is related to bacterial restriction methyltransferases. J Mol Biol. 1988 Oct 20;203(4):971-83
(Latest) J:209593 Sheaffer KL, et al., DNA methylation is required for the control of stem cell differentiation in the small intestine. Genes Dev. 2014 Mar 15;28(6):652-64
All references(217)
Other
accession IDs
MGD-MRK-12204, MGD-MRK-12206, MGD-MRK-8877, MGI:3586536

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory