Sequence Detail

ID/Version

P13864 P97413 Q80ZU3 Q9CSC6 Q9QXX6 (UniProt | EBI)

Last sequence update: 2002-02-21
Last annotation update: 2026-01-28

Sequence description from provider

RecName: Full=DNA (cytosine-5)-methyltransferase 1; Short=Dnmt1; Short=Met-1; EC=2.1.1.37 {ECO:0000269|PubMed:11399088, ECO:0000269|PubMed:17893328, ECO:0000269|PubMed:22323818};AltName: Full=DNA methyltransferase MmuI; Sho

Provider

SWISS-PROT

Sequence

Polypeptide 1620 aa

Source

Organism mouse

See UniProt | EBI for source

Annotated genes and markers

Follow the symbol links to get more information on the GO terms, expression assays, orthologs, phenotypic alleles, and other information for the genes or markers below.

Type	Symbol	Name	GO Terms	Expression Assays	Orthologs	Phenotypic Alleles
Gene	Dnmt1	DNA methyltransferase 1	106	164	3	130

Sequence references in MGI

J:9536 Bestor T, et al., Cloning and sequencing of a cDNA encoding DNA methyltransferase of mouse cells. The carboxyl-terminal domain of the mammalian enzymes is related to bacterial restriction methyltransferases. J Mol Biol. 1988 Oct 20;203(4):971-83
J:36234 Lei H, et al., De novo DNA cytosine methyltransferase activities in mouse embryonic stem cells. Development. 1996 Oct;122(10):3195-205
J:36568 Tucker KL, et al., Complementation of methylation deficiency in embryonic stem cells by a DNA methyltransferase minigene. Proc Natl Acad Sci U S A. 1996 Nov 12;93(23):12920-5
J:37158 Yoder JA, et al., New 5' regions of the murine and human genes for DNA (cytosine-5)-methyltransferase. J Biol Chem. 1996 Dec 6;271(49):31092-7
J:41720 Glickman JF, et al., Peptide mapping of the murine DNA methyltransferase reveals a major phosphorylation site and the start of translation. J Biol Chem. 1997 Jul 11;272(28):17851-7
J:46642 Mertineit C, et al., Sex-specific exons control DNA methyltransferase in mammalian germ cells. Development. 1998 Mar;125(5):889-97
J:61366 Margot JB, et al., Structure and function of the mouse DNA methyltransferase gene: Dnmt1 shows a tripartite structure. J Mol Biol. 2000 Mar 24;297(2):293-300
J:65450 Aguirre-Arteta AM, et al., Expression of an alternative Dnmt1 isoform during muscle differentiation. Cell Growth Differ. 2000 Oct;11(10):551-9
J:68455 Howell CY, et al., Genomic imprinting disrupted by a maternal effect mutation in the Dnmt1 gene. Cell. 2001 Mar 23;104(6):829-38
J:72443 Fatemi M, et al., The activity of the murine DNA methyltransferase Dnmt1 is controlled by interaction of the catalytic domain with the N-terminal part of the enzyme leading to an allosteric activation of the enzyme after binding to methylated DNA. J Mol Biol. 2001 Jun 22;309(5):1189-99
J:81304 Rountree MR, et al., DNMT1 binds HDAC2 and a new co-repressor, DMAP1, to form a complex at replication foci. Nat Genet. 2000 Jul;25(3):269-77
J:99680 The FANTOM Consortium and RIKEN Genome Exploration Research Group and Genome Science Group (Genome Network Project Core Group), The Transcriptional Landscape of the Mammalian Genome. Science. 2005;309(5740):1559-1563
J:100129 Zhou Y, et al., The PHD finger/bromodomain of NoRC interacts with acetylated histone H4K16 and is sufficient for rDNA silencing. Curr Biol. 2005 Aug 9;15(15):1434-8
J:113866 Fuks F, et al., DNA methyltransferase Dnmt1 associates with histone deacetylase activity. Nat Genet. 2000 Jan;24(1):88-91
J:129049 Takebayashi S, et al., Major and essential role for the DNA methylation mark in mouse embryogenesis and stable association of DNMT1 with newly replicated regions. Mol Cell Biol. 2007 Dec;27(23):8243-58
J:143718 Trost M, et al., The phagosomal proteome in interferon-gamma-activated macrophages. Immunity. 2009 Jan;30(1):143-54
J:150999 Schermelleh L, et al., Dynamics of Dnmt1 interaction with the replication machinery and its role in postreplicative maintenance of DNA methylation. Nucleic Acids Res. 2007;35(13):4301-12
J:159064 Easwaran HP, et al., Replication-independent chromatin loading of Dnmt1 during G2 and M phases. EMBO Rep. 2004 Dec;5(12):1181-6
J:168854 Song J, et al., Structure of DNMT1-DNA complex reveals a role for autoinhibition in maintenance DNA methylation. Science. 2011 Feb 25;331(6020):1036-40
J:173197 Takeshita K, et al., From the Cover: Structural insight into maintenance methylation by mouse DNA methyltransferase 1 (Dnmt1). Proc Natl Acad Sci U S A. 2011 May 31;108(22):9055-9
J:188893 Qin W, et al., Usp7 and Uhrf1 control ubiquitination and stability of the maintenance DNA methyltransferase Dnmt1. J Cell Biochem. 2011 Feb;112(2):439-44
J:203468 Park J, et al., SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways. Mol Cell. 2013 Jun 27;50(6):919-30
J:250978 Ianni A, et al., Sirt7 stabilizes rDNA heterochromatin through recruitment of DNMT1 and Sirt1. Biochem Biophys Res Commun. 2017 Oct 21;492(3):434-440
J:292518 Huttlin EL, et al., A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89
J:371660 Ishiyama S, et al., Structure of the Dnmt1 Reader Module Complexed with a Unique Two-Mono-Ubiquitin Mark on Histone H3 Reveals the Basis for DNA Methylation Maintenance. Mol Cell. 2017 Oct 19;68(2):350-360.e7
J:371699 Song J, et al., Structure-based mechanistic insights into DNMT1-mediated maintenance DNA methylation. Science. 2012 Feb 10;335(6069):709-12
J:371703 Qin W, et al., DNA methylation requires a DNMT1 ubiquitin interacting motif (UIM) and histone ubiquitination. Cell Res. 2015 Aug;25(8):911-29