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Dhfr
Gene Detail
Symbol

Name
ID
Dhfr
dihydrofolate reductase
MGI:94890
Synonyms
8430436I03Rik
Feature Type
protein coding gene
Genetic Map
Chromosome 13
47.64 cM
Detailed Genetic Map ± 1 cM


Mapping data(44)
Sequence Map
Chr13:92354783-92389053 bp, + strand
From NCBI annotation of GRCm38

  34271 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:56470  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: DHFR
Gene Tree: Dhfr

Human
homologs
DHFR, dihydrofolate reductase
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 1719
neXtProt AC: NX_P00374

Human Synonyms: DHFRP1, DYR

Human Chr (Location): 5q14.1; chr5:80626226-80654981 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human DHFR

Mutations,
alleles, and
phenotypes
All mutations/alleles(12) : Gene trapped(5) Targeted(7)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Dhfr interacts with 362 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (17 annotations)
Process dihydrofolate metabolic process, glycine biosynthetic process, ...
Function dihydrofolate reductase activity, dihydrofolic acid binding, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (115)    Tissues (115)    Images (13)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 94
RNase protection 21
cDNA source data(69)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA DHFR ; Xenbase dhfr ; ZFIN dhfr    NEW 
Molecular
reagents
All nucleic(76) Genomic(3) cDNA(70) Primer pair(1) Other(2)
Microarray probesets(6)
Other database
links
Ensembl Gene Model ENSMUSG00000021707 (Evidence)
Entrez Gene 13361 (Evidence)
UniGene 23695
DFCI TC1580687, TC1620436, TC1652431
DoTS DT.87068780
NIA Mouse Gene Index U043357
EC 1.5.1.3
PDB 2FZJ, 1U70, 3D80, 3D84, 3K45, 3K47
Consensus CDS Project CCDS26680.1
International Mouse Phenotyping Consortium Status Dhfr
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 13361 NCBI Gene Model | MGI Sequence Detail 34271 C57BL/6J ±  kb
transcript NM_010049 RefSeq | MGI Sequence Detail 5307 C57BL/6 
polypeptide P00375 UniProt | EBI | MGI Sequence Detail 187 Not Applicable 

For the selected sequences
All sequences(35) RefSeq(2) UniProt(2)
Polymorphisms
All PCR and RFLP(15) : PCR(1) RFLP(14) SNPs within 2kb(167 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR012259 Dihydrofolate reductase
InterPro IPR017925 Dihydrofolate reductase conserved site
InterPro IPR001796 Dihydrofolate reductase domain
InterPro IPR024072 Dihydrofolate reductase-like domain
Protein Ontology PR:000006844 dihydrofolate reductase
Graphical View of Protein Domain Structure
References
(Earliest) J:30524 HAKALA MT, et al., Relation of folic acid reductase to amethopterin resistance in cultured mammalian cells. J Biol Chem. 1961 Mar;236:952-8
(Latest) J:200267 Schreiner B, et al., Role of the AAA protease Yme1 in folding of proteins in the intermembrane space of mitochondria. Mol Biol Cell. 2012 Nov;23(22):4335-46
All references(93)
Other
accession IDs
MGD-MRK-8841, MGI:1918808, MGI:2145281, MGI:2145455, MGI:3034358

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory