Automated description from the Alliance of Genome Resources (Release 7.0.0)
Enables dihydrofolate reductase activity. Involved in regulation of removal of superoxide radicals; tetrahydrobiopterin biosynthetic process; and tetrahydrofolate interconversion. Located in mitochondrion. Is active in nucleus. Is expressed in several structures, including genitourinary system; hemolymphoid system; integumental system; limb; and nervous system. Human ortholog(s) of this gene implicated in acute lymphoblastic leukemia. Orthologous to several human genes including DHFR (dihydrofolate reductase).