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Dcn
Gene Detail
Symbol

Name
ID
Dcn
decorin
MGI:94872
Synonyms
DC, SLRR1B
Feature Type
protein coding gene
Genetic Map
Chromosome 10
50.27 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr10:97479500-97518162 bp, + strand
From NCBI annotation of GRCm38

  38663 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:22430  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: class I small leucine-rich proteoglycan, decorin/asporin/byglycan types
Gene Tree: Dcn

Human
homologs
Human Homolog DCN, decorin
NCBI Gene ID 1634
neXtProt AC  NX_P07585
Human Synonyms  CSCD, DSPG2, PG40, PGII, PGS2, SLRR1B
Human Chr (Location)  12q21.33; chr12:91145258-91183029 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human DCN
Mutations,
alleles, and
phenotypes
All mutations/alleles(1) : Targeted(1)
Incidental mutations (data from Mutagenetix , APF )
 
Mutant mice have fragile skin and exhibit abnormal collagen morphology in skin and tendons, supporting this gene's role in regulating collagen fiber formation.
 
Phenotype Images(4)
Interactions
Dcn interacts with 93 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (39 records)
Data Summary: Results (290)    Tissues (233)    Images (47)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 2
RNA in situ 226
Northern blot 12
RT-PCR 50
cDNA source data(297)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(311) Genomic(5) cDNA(299) Primer pair(7)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000019929 (Evidence)
Entrez Gene13179 (Evidence)
UniGene56769
DFCITC1571977, TC1575139, TC1598893, TC1605472
DoTSDT.101381841, DT.497018, DT.91303331, DT.94146166, DT.97414905
NIA Mouse Gene IndexU011935
Consensus CDS ProjectCCDS24141.1
International Mouse Knockout Project StatusDcn
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 13179 NCBI Gene Model | MGI Sequence Detail 38663 C57BL/6J ±  kb
transcript NM_001190451 RefSeq | MGI Sequence Detail 1886 C57BL/6 
polypeptide P28654 UniProt | EBI | MGI Sequence Detail 354 Not Applicable 

For the selected sequences
All sequences(39) RefSeq(4) UniProt(4)
Polymorphisms
All PCR and RFLP(2) : PCR(1) RFLP(1) SNPs within 2kb(216 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001611 Leucine-rich repeat
InterPro IPR000372 Leucine-rich repeat-containing N-terminal
InterPro IPR003591 Leucine-rich repeat, typical subtype
InterPro IPR016352 Small leucine-rich proteoglycan, class I, decorin/asporin/byglycan
Protein Ontology PR:000000094 decorin
Graphical View of Protein Domain Structure
References
(Earliest) J:14605 Bianco P, et al., Expression and localization of the two small proteoglycans biglycan and decorin in developing human skeletal and non-skeletal tissues. J Histochem Cytochem. 1990 Nov;38(11):1549-63
(Latest) J:207829 Dupuis LE, et al., Small leucine-rich proteoglycans exhibit unique spatiotemporal expression profiles during cardiac valve development. Dev Dyn. 2014 Apr;243(4):601-11
All references(114)
Other
accession IDs
MGD-MRK-8811

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory