Dcn
Gene Detail

Symbol Name ID

Dcn decorin MGI:94872

Synonyms

DC, SLRR1B

Feature Type

protein coding gene

Genetic Map

Chromosome 10

50.27 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)

Sequence Map

Chr10:97479500-97518162 bp, + strand From NCBI annotation of GRCm38   38663 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:22430  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 chicken; 1 zebrafish

Protein SuperFamily: class I small leucine-rich proteoglycan, decorin/asporin/byglycan types
Gene Tree: Dcn

Human homologs

Human Homolog		DCN, decorin
NCBI Gene ID		1634
neXtProt AC		NX_P07585
Human Synonyms		CSCD, DSPG2, PG40, PGII, PGS2, SLRR1B
Human Chr (Location)		12q21.33; chr12:91539035-91576806 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human DCN

Alleles and phenotypes

All alleles(1) : Targeted(1)
 

Mutant mice have fragile skin and exhibit abnormal collagen morphology in skin and tendons, supporting this gene's role in regulating collagen fiber formation.

 
Alleles Annotated to Human Diseases(1)    Phenotype Images(4)

Gene Ontology (GO) classifications

All GO classifications: (11 annotations)

Process	peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan
Component	collagen type VI, extracellular matrix, ...
Function	collagen binding, extracellular matrix binding, ...

External Resources: FuncBase

Expression

Literature Summary: (36 records)
Data Summary: Results (221)    Tissues (174)    Images (37)
Theiler Stages: 17, 19, 20, 22, 23, 24, 25, 28

Assay Type	Results
RNA in situ	159
Northern blot	12
RT-PCR	50

cDNA source data(296)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(309) Genomic(5) cDNA(297) Primer pair(7)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000019929 (Evidence)
Entrez Gene	13179 (Evidence)
UniGene	56769
DFCI	TC1571977, TC1575139, TC1598893, TC1605472
DoTS	DT.101381841, DT.497018, DT.91303331, DT.94146166, DT.97414905
NIA Mouse Gene Index	U011935
Consensus CDS Project	CCDS24141.1
International Mouse Knockout Project Status	Dcn

Sequences

Length	Strain/Species
genomic	13179	NCBI Gene Model | MGI Sequence Detail	38663	C57BL/6J
transcript	NM_001190451	RefSeq | MGI Sequence Detail	1886	C57BL/6
polypeptide	P28654	UniProt | EBI | MGI Sequence Detail	354	Not Applicable

All sequences(39) RefSeq(4) UniProt(4)

Polymorphisms

All PCR and RFLP(2) : PCR(1) RFLP(1) SNPs(185 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001611	Leucine-rich repeat
InterPro	IPR000372	Leucine-rich repeat-containing N-terminal
InterPro	IPR003591	Leucine-rich repeat, typical subtype
InterPro	IPR016352	Small leucine-rich proteoglycan, class I, decorin/asporin/byglycan
Protein Ontology	PR:000000094	decorin

Graphical View of Protein Domain Structure

References

(Earliest) J:14605 Bianco P, et al., Expression and localization of the two small proteoglycans biglycan and decorin in developing human skeletal and non-skeletal tissues. J Histochem Cytochem. 1990 Nov;38(11):1549-63
(Latest) J:194215 Dunkman AA, et al., Decorin expression is important for age-related changes in tendon structure and mechanical properties. Matrix Biol. 2013 Jan;32(1):3-13
All references(103)

Other accession IDs

MGD-MRK-8811