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Targeted Allele Detail
Symbol: Dcntm1Ioz
Name: decorin; targeted mutation 1, Renato V Iozzo
MGI ID: MGI:2153002
Synonyms: Dcn-
Gene: Dcn  Location: Chr10:97315471-97354005 bp, + strand  Genetic Position: Chr10, 50.27 cM
Alliance: Dcntm1Ioz page
Dcntm1Ioz/Dcntm1Ioz mice display thin and fragile skin

Show the 4 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:39212
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
Mutation detailsA neomycin resistance cassette was inserted into exon 2. Northern blot analysis demonstrated that no transcript was detectable in sternum, heart, liver or kidney of homozygous mice. Immunoblot analysis on extracts of tail tissue revealed that no expressed protein was detectable in homozygous mice. (J:39212)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Structures Affected by this Mutation: 13 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Dcn Mutation:  13 strains or lines available
Original:  J:39212 Danielson KG, et al., Targeted disruption of decorin leads to abnormal collagen fibril morphology and skin fragility. J Cell Biol. 1997 Feb 10;136(3):729-43
All:  50 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.22
The Jackson Laboratory