Tg(Kera-cre)KC4.3Wwk
Transgene Detail

Summary

• Symbol: Tg(Kera-cre)KC4.3Wwk
• Name: transgene insertion KC4.3, Winston W Y Kao
• MGI ID: MGI:3849605
• Synonyms: KC4.3, Kera-Cre
• Transgene: Tg(Kera-cre)KC4.3Wwk Location: unknown
• Alliance: Tg(Kera-cre)KC4.3Wwk page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Recombinase)
• Mutation: Insertion
• Tg(Kera-cre)KC4.3Wwk expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  Not Specified	Kera

• Mutation details: A minigene containing a 3.2 kb fragment 5' of the transcription start site of the Kera gene, exon 1 (172 bp), intron 1 (1.4 kb), exon 2 (7 bp) preceding the ATG start codon of the Kera mRNA, and a cre minigene with IRES and nuclear localization sequences (NLS) followed by the SV40 polyadenylation (pA) signal, was injected into FVB/N oocytes. Mice were crossed with R26R reporter mice to assess cre activity. Founder line KC4.3, showing strong expression and line KC4.1 with moderate expression were characterized further. (J:149921)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Kera (species not specified) Summary of all recombinase alleles driven by Kera. Comparative matrix view of recombinase activities

Disease models

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:149921 Weng DY, et al., Promiscuous recombination of LoxP alleles during gametogenesis in cornea Cre driver mice. Mol Vis. 2008;14:562-71
• All: 6 reference(s)