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Ppp1r1b
Gene Detail
Symbol

Name
ID
Ppp1r1b
protein phosphatase 1, regulatory (inhibitor) subunit 1B
MGI:94860
Synonyms
Darpp32, DARPP-32
Feature Type
protein coding gene
Genetic Map
Chromosome 11
61.75 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr11:98348404-98357796 bp, + strand
From VEGA annotation of GRCm38

  9393 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:12972  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog

HCOP human homology predictions: PPP1R1B
Gene Tree: Ppp1r1b

Human
homologs
PPP1R1B, protein phosphatase 1, regulatory (inhibitor) subunit 1B
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 84152
neXtProt AC: NX_Q9UD71

Human Synonyms: DARPP32, DARPP-32

Human Chr (Location): 17q12; chr17:39626208-39636625 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(9) : Targeted(9)
Genomic Mutations involving Ppp1r1b (1)
 
Homozygotes for a targeted null mutation exhibit elevated substance P-like immunoreactivity and deficits in responses to dopamine, cocaine, ethanol, and antipsychotic drugs. Abnormalities in striatal function were also noted.
 
Interactions
Ppp1r1b interacts with 161 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (22 annotations)
Process intracellular signal transduction, negative regulation of catalytic activity, ...
Component cytoplasm, intracellular, ...
Function D1 dopamine receptor binding, D2 dopamine receptor binding, ...
External Resources: FuncBase
Expression
Literature Summary: (50 records)
Data Summary: Results (55)    Tissues (39)    Images (23)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 14
RNA in situ 31
Western blot 10
cDNA source data(80)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase ppp1r1b    NEW 
Molecular
reagents
All nucleic(83) Genomic(2) cDNA(80) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000002634 (Evidence)
Ensembl Gene Model ENSMUSG00000061718 (Evidence)
Entrez Gene 19049 (Evidence)
UniGene 45372
DFCI TC1596994, TC1575984
DoTS DT.55242164, DT.530306, DT.97396404, DT.101204037
NIA Mouse Gene Index U013294
Consensus CDS Project CCDS25344.1
International Mouse Phenotyping Consortium Status Ppp1r1b
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000002634 VEGA Gene Model | MGI Sequence Detail 9393 C57BL/6J ±  kb
transcript OTTMUST00000005141 VEGA | MGI Sequence Detail 2001 Not Applicable 
polypeptide OTTMUSP00000002442 VEGA | MGI Sequence Detail 194 Not Applicable 

For the selected sequences
All sequences(47) RefSeq(2) UniProt(2)
Polymorphisms
SNPs within 2kb(59 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR015670 Dopamine/cAMP-regulated neuronal phosphoprotein
InterPro IPR008466 Protein phosphatase inhibitor, 1DARPP-32
Protein Ontology PR:000013121 protein phosphatase 1 regulatory subunit 1B
References
(Earliest) J:49 Perez RG, et al., Regional distribution of DARPP-32 (dopamine- and adenosine 3',5'-monophosphate-regulated phosphoprotein of Mr = 32,000) mRNA in mouse brain. J Comp Neurol. 1992 Apr 15;318(3):304-15
(Latest) J:216086 Guibinga GH, et al., Striatal neurodevelopment is dysregulated in purine metabolism deficiency and impacts DARPP-32, BDNF/TrkB expression and signaling: new insights on the molecular and cellular basis of Lesch-Nyhan Syndrome. PLoS One. 2014;9(5):e96575
All references(113)
Other
accession IDs
MGD-MRK-8796, MGI:2144421

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory