Ppp1r1b
Gene Detail

Symbol Name ID

Ppp1r1b protein phosphatase 1, regulatory (inhibitor) subunit 1B MGI:94860

Synonyms

Darpp32, DARPP-32

Feature Type

protein coding gene

Genetic Map

Chromosome 11

61.75 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr11:98348404-98357796 bp, + strand From VEGA annotation of GRCm38   9393 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:12972  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken

Gene Tree: Ppp1r1b

Human homologs

Human Homolog		PPP1R1B, protein phosphatase 1, regulatory (inhibitor) subunit 1B
NCBI Gene ID		84152
neXtProt AC		NX_Q9UD71
Human Synonyms		DARPP32, DARPP-32
Human Chr (Location)		17q12; chr17:37783177-37792878 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(8) : Targeted(8)
 

Homozygotes for a targeted null mutation exhibit elevated substance P-like immunoreactivity and deficits in responses to dopamine, cocaine, ethanol, and antipsychotic drugs. Abnormalities in striatal function were also noted.

 

Gene Ontology (GO) classifications

All GO classifications: (15 annotations)

Process	intracellular signal transduction, negative regulation of catalytic activity, ...
Component	cytoplasm, neuronal cell body, ...
Function	protein phosphatase inhibitor activity, protein serine/threonine phosphatase inhibitor activity, ...

External Resources: FuncBase

Expression

Literature Summary: (43 records)
Data Summary: Results (47)    Tissues (36)    Images (15)
Theiler Stages: 19, 23, 25, 26, 28

Assay Type	Results
Immunohistochemistry	6
RNA in situ	31
Western blot	10

cDNA source data(11)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(14) Genomic(2) cDNA(11) Other(1)
Microarray probesets(3)

Other database links

VEGA Gene Model	OTTMUSG00000002634 (Evidence)
Ensembl Gene Model	ENSMUSG00000061718 (Evidence)
Entrez Gene	19049 (Evidence)
DFCI	TC1575984, TC1596994
DoTS	DT.101204037, DT.530306, DT.55242164, DT.97396404
NIA Mouse Gene Index	U013294
Consensus CDS Project	CCDS25344.1
International Mouse Knockout Project Status	Ppp1r1b

Sequences

Length	Strain/Species
genomic	OTTMUSG00000002634	VEGA Gene Model | MGI Sequence Detail	9393	C57BL/6J
transcript	OTTMUST00000005141	VEGA | MGI Sequence Detail	2001	Not Applicable
polypeptide	OTTMUSP00000002442	VEGA | MGI Sequence Detail	194	Not Applicable

All sequences(47) RefSeq(2) UniProt(2)

Polymorphisms

SNPs(45 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR015670	Dopamine/cAMP-regulated neuronal phosphoprotein
InterPro	IPR008466	Protein phosphatase inhibitor, 1DARPP-32
Protein Ontology	PR:000013121	protein phosphatase 1 regulatory subunit 1B

References

(Earliest) J:49 Perez RG, et al., Regional distribution of DARPP-32 (dopamine- and adenosine 3',5'-monophosphate-regulated phosphoprotein of Mr = 32,000) mRNA in mouse brain. J Comp Neurol. 1992 Apr 15;318(3):304-15
(Latest) J:196080 Elsen GE, et al., The protomap is propagated to cortical plate neurons through an Eomes-dependent intermediate map. Proc Natl Acad Sci U S A. 2013 Mar 5;110(10):4081-6
All references(101)

Other accession IDs

MGD-MRK-8796, MGI:2144421