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Ywhae
Gene Detail
Symbol

Name
ID
Ywhae
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide
MGI:894689
STS
Synonyms
14-3-3 epsilon
Feature Type
protein coding gene
Genetic Map
Chromosome 11
45.92 cM, cytoband B2
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr11:75732869-75765845 bp, + strand
From VEGA annotation of GRCm38

  32977 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:100743  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: 14-3-3 protein
Gene Tree: Ywhae

Human
homologs
Human Homolog YWHAE, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon
NCBI Gene ID 7531
neXtProt AC  NX_P62258
Human Synonyms  14-3-3E, HEL2, KCIP-1, MDCR, MDS
Human Chr (Location)  17p13.3; chr17:1344540-1400375 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(124) : Gene trapped(117) Targeted(7)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for disruptions of this gene usually die around birth. The small percentage of survivors are small in size and display central nervous system abnormalities including a thinner cortex and a disorganized pyramidal cell layer in the hippocampus.
 
Human Diseases Modeled Using Mouse Ywhae (2)    Alleles Annotated to Human Diseases(1)   
Interactions
Ywhae interacts with 232 markers (Mir7-1, Mir9-1, Mir9-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (40 annotations)
Process cerebral cortex development, hippocampus development, ...
Component axon, cytoplasm, ...
Function enzyme binding, histone deacetylase binding, ...
External Resources: FuncBase
Expression
Literature Summary: (13 records)
Data Summary: Results (127)    Tissues (106)    Images (28)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 103
Western blot 24
cDNA source data(13)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(22) Genomic(7) cDNA(13) Primer pair(2)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000006219 (Evidence)
Ensembl Gene ModelENSMUSG00000020849 (Evidence)
Entrez Gene22627 (Evidence)
DFCITC1573674
DoTSDT.101339345, DT.101339334, DT.101339347, DT.91309042, DT.94213719, DT.94150871
NIA Mouse Gene IndexU012960
Consensus CDS ProjectCCDS25056.1
International Mouse Knockout Project StatusYwhae
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000006219 VEGA Gene Model | MGI Sequence Detail 32977 C57BL/6J ±  kb
transcript OTTMUST00000014043 VEGA | MGI Sequence Detail 2100 Not Applicable 
polypeptide OTTMUSP00000006521 VEGA | MGI Sequence Detail 255 Not Applicable 

For the selected sequences
All sequences(83) RefSeq(2) UniProt(11)
Polymorphisms
SNPs within 2kb(118 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR023410 14-3-3 domain
InterPro IPR000308 14-3-3 protein
InterPro IPR023409 14-3-3 protein, conserved site
Protein Ontology PR:000003104 14-3-3 protein epsilon
References
(Earliest) J:25272 McConnell JE, et al., The mouse 14-3-3 epsilon isoform, a kinase regulator whose expression pattern is modulated in mesenchyme and neuronal differentiation. Dev Biol. 1995 May;169(1):218-28
(Latest) J:203495 Neukamm SS, et al., Phosphorylation of serine 1137/1138 of mouse insulin receptor substrate (IRS) 2 regulates cAMP-dependent binding to 14-3-3 proteins and IRS2 protein degradation. J Biol Chem. 2013 Jun 7;288(23):16403-15
All references(84)
Disease annotation references (2)
Other
accession IDs
MGI:2144388

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory