Ywhae
Gene Detail

Symbol Name ID

Ywhae tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide MGI:894689

STS

D11Rub13

Synonyms

14-3-3 epsilon

Feature Type

protein coding gene

Genetic Map

Chromosome 11

45.92 cM, cytoband B2
Detailed Genetic Map ± 1 cM


Mapping data(6)

Sequence Map

Chr11:75732869-75765845 bp, + strand From VEGA annotation of GRCm38   32977 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:38223  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: 14-3-3 protein
Gene Tree: Ywhae

Human homologs

Human Homolog		YWHAE, tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide
NCBI Gene ID		7531
neXtProt AC		NX_P62258
Human Synonyms		14-3-3E, KCIP-1, MDCR, MDS
Human Chr (Location)		17p13.3; chr17:1247834-1303556 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(125) : Targeted(7) Gene trapped(118)
 

Mice homozygous for disruptions of this gene usually die around birth. The small percentage of survivors are small in size and display central nervous system abnormalities including a thinner cortex and a disorganized pyramidal cell layer in the hippocampus.

 
Human Diseases Modeled Using Mouse Ywhae (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (23 annotations)

Process	cerebral cortex development, hippocampus development, ...
Component	axon part, cytoplasm, ...
Function	enzyme binding, histone deacetylase binding, ...

External Resources: FuncBase

Expression

Literature Summary: (10 records)
Data Summary: Results (127)    Tissues (106)    Images (28)
Theiler Stages: 8, 10, 13, 14, 17, 22, 24, 28

Assay Type	Results
RNA in situ	103
Western blot	24

cDNA source data(849)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(858) Genomic(7) cDNA(849) Primer pair(2)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000006219 (Evidence)
Ensembl Gene Model	ENSMUSG00000020849 (Evidence)
Entrez Gene	22627 (Evidence)
UniGene	234700
DFCI	TC1573674
DoTS	DT.101339334, DT.101339345, DT.101339347, DT.91309042, DT.94150871, DT.94213719
NIA Mouse Gene Index	U012960
Consensus CDS Project	CCDS25056.1
International Mouse Knockout Project Status	Ywhae

Sequences

Length	Strain/Species
genomic	OTTMUSG00000006219	VEGA Gene Model | MGI Sequence Detail	32977	C57BL/6J
transcript	OTTMUST00000014043	VEGA | MGI Sequence Detail	2100	Not Applicable
polypeptide	OTTMUSP00000006521	VEGA | MGI Sequence Detail	255	Not Applicable

All sequences(78) RefSeq(2) UniProt(6)

Polymorphisms

SNPs(87 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR023410	14-3-3 domain
InterPro	IPR000308	14-3-3 protein
InterPro	IPR023409	14-3-3 protein, conserved site
Protein Ontology	PR:000003104	14-3-3 protein epsilon

References

(Earliest) J:25272 McConnell JE, et al., The mouse 14-3-3 epsilon isoform, a kinase regulator whose expression pattern is modulated in mesenchyme and neuronal differentiation. Dev Biol. 1995 May;169(1):218-28
(Latest) J:192860 Kosaka Y, et al., 14-3-3epsilon plays a role in cardiac ventricular compaction by regulating the cardiomyocyte cell cycle. Mol Cell Biol. 2012 Dec;32(24):5089-102
All references(71)

Other accession IDs

MGI:2144388