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Cacnb2
Gene Detail
Symbol

Name
ID
Cacnb2
calcium channel, voltage-dependent, beta 2 subunit
MGI:894644
Synonyms
Cavbeta2, Cchb2
Feature Type
protein coding gene
Genetic Map
Chromosome 2
10.70 cM
Detailed Genetic Map ± 1 cM


Mapping data(13)
Sequence Map
Chr2:14603088-14987908 bp, + strand
From VEGA annotation of GRCm38

  384821 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:75191  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: CACNB2
Gene Tree: Cacnb2

Human
homologs
CACNB2, calcium channel, voltage-dependent, beta 2 subunit
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 783
neXtProt AC: NX_Q08289

Human Synonyms: CACNLB2, CAVB2, MYSB

Human Chr (Location): 10p12; chr10:18140677-18541759 (+)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human CACNB2

Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Targeted(6) Transgenic(2)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a null allele exhibit lethality at E10.5 with growth retardation, abnormal yolk vasculature and abnormal cardiac development and function.
 
Interactions
Cacnb2 interacts with 352 markers (Mir1b, Mir7-1, Mir9-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (29 annotations)
Process calcium ion import, calcium ion transmembrane transport, ...
Component membrane, plasma membrane, ...
Function calcium channel activity, calcium channel regulator activity, ...
External Resources: FuncBase
Expression
Literature Summary: (11 records)
Data Summary: Results (102)    Tissues (60)    Images (24)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 17
RNA in situ 60
RT-PCR 25
cDNA source data(15)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase cacnb2 ; ZFIN cacnb2a, cacnb2b    NEW 
Molecular
reagents
All nucleic(25) cDNA(21) Primer pair(3) Other(1)
Microarray probesets(5)
Other database
links
VEGA Gene Model OTTMUSG00000011219 (Evidence)
Ensembl Gene Model ENSMUSG00000057914 (Evidence)
Entrez Gene 12296 (Evidence)
DFCI TC1599395, TC1585900, TC1626718
DoTS DT.481806, DT.101172909, DT.484513, DT.97352848
NIA Mouse Gene Index U001410
Consensus CDS Project CCDS15702.1
International Mouse Phenotyping Consortium Status Cacnb2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000011219 VEGA Gene Model | MGI Sequence Detail 384821 C57BL/6J ±  kb
transcript OTTMUST00000026328 VEGA | MGI Sequence Detail 3945 Not Applicable 
polypeptide OTTMUSP00000012041 VEGA | MGI Sequence Detail 655 Not Applicable 

For the selected sequences
All sequences(111) RefSeq(28) UniProt(9)
Polymorphisms
RFLP(2) : SNPs within 2kb(1252 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008145 Guanylate kinase/L-type calcium channel
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
InterPro IPR001452 Src homology-3 domain
InterPro IPR005444 Voltage-dependent calcium channel, L-type, beta-2 subunit
InterPro IPR000584 Voltage-dependent calcium channel, L-type, beta subunit
Protein Ontology PR:000004947 voltage-dependent L-type calcium channel subunit beta-2
References
(Earliest) J:25718 Massa E, et al., Comparison of fura-2 imaging and electrophysiological analysis of murine calcium channel alpha 1 subunits coexpressed with novel beta 2 subunit isoforms. Mol Pharmacol. 1995 Apr;47(4):707-16
(Latest) J:218379 Lee A, et al., Characterization of Cav1.4 Complexes (alpha11.4, beta2, and alpha2delta4) in HEK293T Cells and in the Retina. J Biol Chem. 2015 Jan 16;290(3):1505-21
All references(62)
Other
accession IDs
MGD-MRK-24068, MGI:103200, MGI:2139283, MGI:3583767

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory