Cacnb2
Gene Detail

Symbol Name ID

Cacnb2 calcium channel, voltage-dependent, beta 2 subunit MGI:894644

Synonyms

Cavbeta2, Cchb2

Feature Type

protein coding gene

Genetic Map

Chromosome 2

10.70 cM
Detailed Genetic Map ± 1 cM


Mapping data(13)

Sequence Map

Chr2:14604306-14987908 bp, + strand From VEGA annotation of GRCm38   383603 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:75191  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Cacnb2

Human homologs

Human Homolog		CACNB2, calcium channel, voltage-dependent, beta 2 subunit
NCBI Gene ID		783
neXtProt AC		NX_Q08289
Human Synonyms		CACNLB2, CAVB2, MYSB
Human Chr (Location)		10p12; chr10:18429606-18830688 (+)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human CACNB2

Alleles and phenotypes

All alleles(6) : Targeted(6)
 

Mice homozygous for a null allele exhibit lethality at E10.5 with growth retardation, abnormal yolk vasculature and abnormal cardiac development and function.

 

Gene Ontology (GO) classifications

All GO classifications: (28 annotations)

Process	calcium ion import, calcium ion transmembrane transport, ...
Component	membrane, plasma membrane, ...
Function	calcium channel activity, calcium channel regulator activity, ...

External Resources: FuncBase

Expression

Literature Summary: (9 records)
Data Summary: Results (94)    Tissues (51)    Images (20)
Theiler Stages: 15, 17, 20, 23, 24, 25, 26, 28

Assay Type	Results
Immunohistochemistry	17
RNA in situ	60
RT-PCR	17

cDNA source data(15)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(24) cDNA(21) Primer pair(2) Other(1)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000011219 (Evidence)
Ensembl Gene Model	ENSMUSG00000057914 (Evidence)
Entrez Gene	12296 (Evidence)
DFCI	TC1585900, TC1599395, TC1626718
DoTS	DT.101172909, DT.481806, DT.484513, DT.97352848
NIA Mouse Gene Index	U001410
Consensus CDS Project	CCDS15702.1
International Mouse Knockout Project Status	Cacnb2

Sequences

Length	Strain/Species
genomic	OTTMUSG00000011219	VEGA Gene Model | MGI Sequence Detail	383603	C57BL/6J
transcript	OTTMUST00000026328	VEGA | MGI Sequence Detail	3945	Not Applicable
polypeptide	OTTMUSP00000012041	VEGA | MGI Sequence Detail	655	Not Applicable

All sequences(66) RefSeq(5) UniProt(8)

Polymorphisms

RFLP(2) : SNPs(1123 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR008144	Guanylate kinase
InterPro	IPR008145	Guanylate kinase/L-type calcium channel
InterPro	IPR001452	Src homology-3 domain
InterPro	IPR005444	Voltage-dependent calcium channel, L-type, beta-2 subunit
InterPro	IPR000584	Voltage-dependent calcium channel, L-type, beta subunit
Protein Ontology	PR:000004947	voltage-dependent L-type calcium channel subunit beta-2

References

(Earliest) J:25718 Massa E, et al., Comparison of fura-2 imaging and electrophysiological analysis of murine calcium channel alpha 1 subunits coexpressed with novel beta 2 subunit isoforms. Mol Pharmacol. 1995 Apr;47(4):707-16
(Latest) J:193641 Nakano Y, et al., A mutation in the Srrm4 gene causes alternative splicing defects and deafness in the Bronx waltzer mouse. PLoS Genet. 2012;8(10):e1002966
All references(60)

Other accession IDs

MGD-MRK-24068, MGI:103200, MGI:2139283, MGI:3583767