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Cacnb2
Gene Detail
 Symbol
Name
ID
Cacnb2
calcium channel, voltage-dependent, beta 2 subunit
MGI:894644
Synonyms Cavbeta2, Cchb2
Feature Type protein coding gene
Genetic Map
Chromosome 2
10.70 cM
Detailed Genetic Map ± 1 cM


Mapping data(13)
Sequence Map
Chr2:14604306-14987908 bp, + strand
From VEGA annotation of GRCm38

  383603 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:75191  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Cacnb2

Human
homologs
Human Homolog CACNB2, calcium channel, voltage-dependent, beta 2 subunit
NCBI Gene ID 783
neXtProt AC  NX_Q08289
Human Synonyms  CACNLB2, CAVB2, MYSB
Human Chr (Location)  10p12; chr10:18140677-18541759 (+)  GRCh38
Disease Associations  (1) Diseases Associated with Human CACNB2
Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null allele exhibit lethality at E10.5 with growth retardation, abnormal yolk vasculature and abnormal cardiac development and function.
 
Interactions
Cacnb2 interacts with 352 markers (Mir1b, Mir7-1, Mir9-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (27 annotations)
Process calcium ion import, calcium ion transmembrane transport, ...
Component membrane, plasma membrane, ...
Function calcium channel activity, calcium channel regulator activity, ...
External Resources: FuncBase
Expression
Literature Summary: (11 records)
Data Summary: Results (94)    Tissues (51)    Images (20)
Theiler Stages: 15, 17, 20, 23, 24, 25, 26, 28
Assay TypeResults
Immunohistochemistry 17
RNA in situ 60
RT-PCR 17
cDNA source data(15)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(24) cDNA(21) Primer pair(2) Other(1)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000011219 (Evidence)
Ensembl Gene ModelENSMUSG00000057914 (Evidence)
Entrez Gene12296 (Evidence)
DFCITC1585900, TC1599395, TC1626718
DoTSDT.101172909, DT.481806, DT.484513, DT.97352848
NIA Mouse Gene IndexU001410
Consensus CDS ProjectCCDS15702.1
International Mouse Knockout Project StatusCacnb2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000011219 VEGA Gene Model | MGI Sequence Detail 383603 C57BL/6J ±  kb
transcript OTTMUST00000026328 VEGA | MGI Sequence Detail 3945 Not Applicable 
polypeptide OTTMUSP00000012041 VEGA | MGI Sequence Detail 655 Not Applicable 

For the selected sequences
All sequences(88) RefSeq(27) UniProt(8)
Polymorphisms RFLP(2) : SNPs within 2kb(1250 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008145 Guanylate kinase/L-type calcium channel
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
InterPro IPR001452 Src homology-3 domain
InterPro IPR005444 Voltage-dependent calcium channel, L-type, beta-2 subunit
InterPro IPR000584 Voltage-dependent calcium channel, L-type, beta subunit
Protein Ontology PR:000004947 voltage-dependent L-type calcium channel subunit beta-2
References (Earliest) J:25718 Massa E, et al., Comparison of fura-2 imaging and electrophysiological analysis of murine calcium channel alpha 1 subunits coexpressed with novel beta 2 subunit isoforms. Mol Pharmacol. 1995 Apr;47(4):707-16
(Latest) J:206966 Etemad S, et al., Differential neuronal targeting of a new and two known calcium channel beta4 subunit splice variants correlates with their regulation of gene expression. J Neurosci. 2014 Jan 22;34(4):1446-61
All references(62)
Other
accession IDs
MGD-MRK-24068, MGI:103200, MGI:2139283, MGI:3583767

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory