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Frzb
Gene Detail
 Symbol
Name
ID
Frzb
frizzled-related protein
MGI:892032
Synonyms fritz, Frp, frzb-1, Sfrp3
Feature Type protein coding gene
Genetic Map
Chromosome 2
48.13 cM
Detailed Genetic Map ± 1 cM


Mapping data(7)
Sequence Map
Chr2:80411970-80447625 bp, - strand
From VEGA annotation of GRCm38

  35656 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1126  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Frzb

Human
homologs
Human Homolog FRZB, frizzled-related protein
NCBI Gene ID 2487
neXtProt AC  NX_Q92765
Human Synonyms  FRE, FRITZ, FRP-3, FRZB1, FRZB-1, FRZB-PEN, FZRB, hFIZ, OS1, SFRP3, SRFP3
Human Chr (Location)  2q32.1; chr2:182833275-182866770 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human FRZB
Alleles
and
phenotypes
All alleles(7) : Gene trapped(1) Targeted(6)
Incidental mutations (data from Mutagenetix )
 
Mice homozygous for one null allele display defects in motor coordination and capability and a decrease in thermal pain sensation. Mice homozygous for another null allele display enhanced reactive bone formation and cortical bone abnormalities.
 
Gene Ontology
(GO)
classifications
All GO classifications: (35 annotations)
Process brain development, cell differentiation, ...
Component cytoplasm, extracellular region, ...
Function PDZ domain binding, protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (47 records)
Data Summary: Results (728)    Tissues (386)    Images (110)
Theiler Stages: 2, 3, 5, 8, 9, 11, 13, 15, 17, 19, 20, 21, 22, 23, 25, 28
Assay TypeResults
RNA in situ 596
In situ reporter (knock in) 36
Northern blot 8
RT-PCR 88
cDNA source data(45)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress
Molecular
reagents
All nucleic(60) Genomic(3) cDNA(47) Primer pair(7) Other(3)
Microarray probesets(5)
Other database
links
VEGA Gene ModelOTTMUSG00000013372 (Evidence)
Ensembl Gene ModelENSMUSG00000027004 (Evidence)
Entrez Gene20378 (Evidence)
UniGene427436
DFCITC1576425, TC1683567
DoTSDT.60109884
NIA Mouse Gene IndexU129873
PDB1IJX
Consensus CDS ProjectCCDS16176.1
International Mouse Knockout Project StatusFrzb
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000013372 VEGA Gene Model | MGI Sequence Detail 35656 C57BL/6J ±  kb
transcript OTTMUST00000032322 VEGA | MGI Sequence Detail 3149 Not Applicable 
polypeptide OTTMUSP00000014350 VEGA | MGI Sequence Detail 323 Not Applicable 

For the selected sequences
All sequences(23) RefSeq(2) UniProt(1)
Polymorphisms All PCR and RFLP(3) : PCR(1) RFLP(2) SNPs within 2kb(265 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR020067 Frizzled domain
InterPro IPR015526 Frizzled/secreted frizzled-related protein
InterPro IPR001134 Netrin domain
InterPro IPR018933 Netrin module, non-TIMP type
InterPro IPR026556 Secreted frizzled-related protein 3
InterPro IPR008993 Tissue inhibitor of metalloproteinases-like, OB-fold
Protein Ontology PR:000007674 secreted frizzled-related protein 3
References (Earliest) J:39275 Rattner A, et al., A family of secreted proteins contains homology to the cysteine-rich ligand-binding domain of frizzled receptors. Proc Natl Acad Sci U S A. 1997 Apr 1;94(7):2859-63
(Latest) J:195148 Jang MH, et al., Secreted frizzled-related protein 3 regulates activity-dependent adult hippocampal neurogenesis. Cell Stem Cell. 2013 Feb 7;12(2):215-23
All references(93)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory