Frzb
Gene Detail

Symbol Name ID

Frzb frizzled-related protein MGI:892032

Synonyms

fritz, Frp, frzb-1, Sfrp3

Feature Type

protein coding gene

Genetic Map

Chromosome 2

48.13 cM
Detailed Genetic Map ± 1 cM


Mapping data(7)

Sequence Map

Chr2:80411970-80447625 bp, - strand From VEGA annotation of GRCm38   35656 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Mammalian homology

human; rat; cattle; chimpanzee    (Mammalian Orthology)
Comparative Map (Mouse/Human Frzb ± 2 cM)

Gene Tree: Frzb

Human ortholog

FRZB frizzled-related protein NCBI Gene ID 2487
Human Synonyms: FRE, FRITZ, FRP-3, FRZB1, FRZB-1, FRZB-PEN, FZRB, hFIZ, OS1, SFRP3, SRFP3
Human Chr2:183698002-183731498 bp, - strand Reference GRCh37.p2 Primary Assembly
Human Diseases Associated with Human FRZB (1)

Alleles and phenotypes

All alleles(7) : Targeted(6) Gene trapped(1)
 

Mice homozygous for one null allele display defects in motor coordination and capability and a decrease in thermal pain sensation. Mice homozygous for another null allele display enhanced reactive bone formation and cortical bone abnormalities.

 

Gene Ontology (GO) classifications

All GO classifications: (32 annotations)

Process	brain development, cell differentiation, ...
Component	cytoplasm, extracellular region, ...
Function	PDZ domain binding, protein binding, ...

External Resources: FuncBase

Expression

Literature Summary: (45 records)
Data Summary: Results (593)    Tissues (298)    Images (106)
Theiler Stages: 2, 3, 5, 8, 9, 11, 13, 15, 17, 19, 20, 21, 22, 23, 25, 28

Assay Type	Results
RNA in situ	461
In situ reporter (knock in)	36
Northern blot	8
RT-PCR	88

cDNA source data(44)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(59) Genomic(3) cDNA(46) Primer pair(7) Other(3)
Microarray probesets(5)

Other database links

VEGA Gene Model	OTTMUSG00000013372 (Evidence)
Ensembl Gene Model	ENSMUSG00000027004 (Evidence)
Entrez Gene	20378 (Evidence)
UniGene	427436
DFCI	TC1576425, TC1683567
DoTS	DT.60109884
NIA Mouse Gene Index	U129873
PDB	1IJX
Consensus CDS Project	CCDS16176.1
International Mouse Knockout Project Status	Frzb

Sequences

Length	Strain/Species
genomic	OTTMUSG00000013372	VEGA Gene Model | MGI Sequence Detail	35656	C57BL/6J
transcript	OTTMUST00000032322	VEGA | MGI Sequence Detail	3149	Not Applicable
polypeptide	OTTMUSP00000014350	VEGA | MGI Sequence Detail	323	Not Applicable

All sequences(24) RefSeq(2) UniProt(2)

Polymorphisms

All PCR and RFLP(3) : PCR(1) RFLP(2) SNPs(202 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR020067	Frizzled domain
InterPro	IPR015526	Frizzled/secreted frizzled-related protein
InterPro	IPR001134	Netrin domain
InterPro	IPR018933	Netrin module, non-TIMP type
InterPro	IPR026556	Secreted frizzled-related protein 3
InterPro	IPR008993	Tissue inhibitor of metalloproteinases-like, OB-fold
Protein Ontology	PR:000007674	secreted frizzled-related protein 3

References

(Earliest) J:39275 Rattner A, et al., A family of secreted proteins contains homology to the cysteine-rich ligand-binding domain of frizzled receptors. Proc Natl Acad Sci U S A. 1997 Apr 1;94(7):2859-63
(Latest) J:187883 Van Handel B, et al., Scl represses cardiomyogenesis in prospective hemogenic endothelium and endocardium. Cell. 2012 Aug 3;150(3):590-605
All references(88)