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Frzb Gene Detail
Summary
  • Symbol
    Frzb
  • Name
    frizzled-related protein
  • Synonyms
    fritz, Frp, frzb-1, Sfrp3
  • Feature Type
    protein coding gene
  • IDs
    MGI:892032
    NCBI Gene: 20378
Location & Maps
more
  • Sequence Map
    Chr2:80411970-80447625 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      35656 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 48.13 cM
  • Mapping Data
    7 experiments
Homology
more
  • Human Ortholog
    FRZB, frizzled-related protein
  • Vertebrate Orthologs
    10
  • Human Ortholog
    FRZB, frizzled-related protein
    Orthology source: HomoloGene, HGNC
  • Synonyms
    FRE, FRITZ, FRP-3, FRZB1, FRZB-1, FRZB-PEN, FZRB, hFIZ, OS1, SFRP3, SRFP3
  • Links
    NCBI Gene ID: 2487
    neXtProt AC: NX_Q92765

  • Chr Location
    2q32.1; chr2:182833275-182866770 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 1126
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed
  • HCOP
    human homology predictions: FRZB
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with human FRZB associations

Human Disease Mouse Models
       Osteoarthritis Susceptibility 1; OS1   OMIM: 165720
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    16 phenotypes from 3 alleles in 5 genetic backgrounds
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    10
  • Chemically induced (other)
    1
  • Gene trapped
    1
  • Targeted
    8
  • Genomic Mutations
    3 involving Frzb
  • Incidental Mutations
Mice homozygous for one null allele display defects in motor coordination and capability and a decrease in thermal pain sensation. Mice homozygous for another null allele display enhanced reactive bone formation and cortical bone abnormalities.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000013372 VEGA Gene Model | MGI Sequence Detail 35656 C57BL/6J ±  kb
transcript OTTMUST00000032322 VEGA | MGI Sequence Detail 3149 Not Applicable  
polypeptide OTTMUSP00000014350 VEGA | MGI Sequence Detail 323 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    261 from dbSNP Build 142
  • PCR
  • RFLP
Protein
Information
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  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000007674 secreted frizzled-related protein 3
  • PDB
  • InterPro Domains
    IPR020067 Frizzled domain
    IPR015526 Frizzled/secreted frizzled-related protein
    IPR001134 Netrin domain
    IPR018933 Netrin module, non-TIMP type
    IPR026556 Secreted frizzled-related protein 3
    IPR008993 Tissue inhibitor of metalloproteinases-like, OB-fold
Molecular
Reagents
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  • All nucleic 61
    Genomic 3
    cDNA 47
    Primer pair 7
    Other 4

    Microarray probesets 5
References
more
  • Summaries
    All 90
    Developmental Gene Expression 49
    Gene Ontology 13
    Phenotypes 14
  • Earliest
    J:39275 Rattner A, et al., A family of secreted proteins contains homology to the cysteine-rich ligand-binding domain of frizzled receptors. Proc Natl Acad Sci U S A. 1997 Apr 1;94(7):2859-63
  • Latest
    J:221397 Vanyai HK, et al., Mesodermal expression of Moz is necessary for cardiac septum development. Dev Biol. 2015 Apr 23;

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory